Novel approach for overcoming the stability challenges of lipid-based excipients. Part 2: Application of polyglycerol esters of fatty acids as hot melt coating excipients

Salar-Behzadi, Sharareh; Corzo, Carolina; Lopes, Diogo Gomes; Meindl, Claudia; Lochmann, Dirk; Reyer, Sebastian

doi:10.1016/j.ejpb.2020.01.009

Cited by 10 publications

(7 citation statements)

References 43 publications

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“…Moreover, biomaterial devices need to store in the hospital and need to test the stabilty during storage as followed the storage condition of pharmaceutical products in tropical countries. The stability behavior of coated‐medical devices was evaluated by drug release, drug quantity, and morphology of their devices following the protocol for the verification of pharmaceutical products to verify 33‐35 . In this work, the stability during storage of coated catheters was also investigated to confirm the stability of coated urinary catheter by thickness, morphology, drug quantity, and drug release.…”

Section: Discussionmentioning

confidence: 99%

“…The stability behavior of coated-medical devices was evaluated by drug release, drug quantity, and morphology of their devices following the protocol for the verification of pharmaceutical products to verify. [33][34][35] In this work, the stability during storage of coated catheters was also investigated to confirm the stability of coated urinary catheter by thickness, morphology, drug quantity, and drug release. Data supported that the thickness of thin film under FE-SEM was unchanged, and CHX quan-…”

Section: Stability During Storagementioning

confidence: 99%

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Biocompatibility and stability during storage of Foley urinary catheters coated chlorhexidine loaded nanoparticles by nanocoating: in vitro and in vivo evaluation

et al. 2020

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Foley urinary catheters were coated by chlorhexidine‐loaded micelles and chlorhexidine‐loaded nanospheres. In our prior study, the nanocoating of Foley urinary catheter was investigated for chlorhexidine‐release study, degradation, antibacterial evaluation, and cytotoxicity assessment. These studies presented the 1 month antibacterial property of nanocoating deposited via the layers of micelles and nanospheres. In this study, we evaluated the biocompatibility of these catheters, including hemocompatibility, skin irritation, skin sensitization, and stability during the age of coated urinary catheter. Results demonstrated that coated urinary catheters presented slight hemolysis, whereas skin irritation on rabbit and skin sensitization on Dunkin Hartley guinea pig showed no signs of dermal toxicity, which indicated that inflammation, redness, and swelling did not occur. Moreover, the stability of coated urinary catheters during storage indicated no change in chlorhexidine peaks by high performance liquid chromatography. Information from these studies supports the biocompatibility of coated urinary catheters via nanocoating and their use as indwelling devices to prevent urinary tract infections.

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Section: Discussionmentioning

confidence: 99%

Section: Stability During Storagementioning

confidence: 99%

Biocompatibility and stability during storage of Foley urinary catheters coated chlorhexidine loaded nanoparticles by nanocoating: in vitro and in vivo evaluation

et al. 2020

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“…In this process, as the name implies, meltable CoM, in the molten state, is applied onto substrate particle that solidifies upon cooling. The process uses meltable CoMs with low melting point, usually lipid or waxes [30][31][32][33] . The process requirement is the meltable CoMs had to be heated to molten state for having their solution that then air-atomised and sprayed onto surface of moving solid substrate followed by cooling of the product 30,32,33 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

“…The process uses meltable CoMs with low melting point, usually lipid or waxes [30][31][32][33] . The process requirement is the meltable CoMs had to be heated to molten state for having their solution that then air-atomised and sprayed onto surface of moving solid substrate followed by cooling of the product 30,32,33 . Upon cooling, a continuous film forms on substrate that acts as moisture protection barrier coating or rate-controlling membrane for drug release 4,10 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

“…As a process requirement, during application the coating fluid is required to be maintained at a constant temperature that cannot exceed 150 °C 4,32,33 . Thus meltable materials having molten viscosity below 300 centipoises and melting points below 80 °C are generally suitable, as prior to spraying the molten CoMs are to be maintained at 40-60 °C above their melting point 4 .…”

Section: Hmc Processes/ Technologiesmentioning

confidence: 99%

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Dry-Coating of Powder Particles is Current Trend in Pharmaceutical Field

Alli¹

2021

J. Drug Delivery Ther.

608

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Modification of surface attributes of particles, usually accomplished by coating, is desirous to enhance and maintain their usability. Coating is a multi-step process involves application of the coating material (CoM) onto the substrate, herein powder particles, where the process along with device/ equipment monitors surface attributes of the applied coating. Nowadays competitive market calls for cost cutting to survive product(s). Thus saving of energy and time, minimising number and quantity of additives, reducing and shortening process steps; consequently minimising the coating process cost are main goals while developing coating process for powder particle. Innovation of processes for dry-powder coating (DPC) along with their further development and refinement finds solution to said issues. Further, DPC process does not calls for liquid solvent or solution thus are viewed as cost-effective and environmentally safe, DPC process uses thermo-mechanical methods like mechanofusion, magnetic assisted impaction coating (MAIC), hybridization, rotating fluid-bed process, theta-composer, hot-melt coating (HMC), and many others. Besides these available are non-thermo-mechanical methods namely electrostatic coating; supercritical fluids (SCF) based methods like rapid expansion of supercritical fluid (RESF), gas anti-solvent (GAS), SCF anti-solvent, gas-saturated solution (GSS); vapour coating; and others. Basing on said thermo-mechanical and non-thermo-mechanical principle several DPC methods/ process had been reported in scientific literatures and patents. Said DPC method founds multidisciplinary applications like drug delivery and drug development. Diverse devices are there for the DPC process; their method of working, principle, limitations and benefits along with their applicability in pharmaceutical field are discussed and presented in this article. Keywords: Dry, particle, coating, pharmaceutical, process

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