Novel approach to synthesis of silver nanoparticles in interpolyelectrolyte complexes based on pectin, chitosan, starch and their derivatives

Demchenko, Valeriy; Riabov, S.V.; Sinelnikov, S.I.; Radchenko, O. A.; Kobylinskyi, S.; Rybalchenko, N.

doi:10.1016/j.carbpol.2020.116431

Cited by 33 publications

(28 citation statements)

References 31 publications

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“…Recently, polymer nanocomposites containing nanoparticles of metals such as silver, copper and zinc oxide have attracted the most attention due to their pronounced pharmacological effects, including antimicrobial, antiviral, anti-inflammatory, immunomodulatory, and high stability in extreme conditions [5][6][7][8][9]. A promising polymer for the creation of antimicrobial and antiviral silver-containing nanocomposites is polylactide (PLA), which has significant advantages over other polymers, namely it is thermoplastic and is characterized by high mechanical strength, biocompatibility and non-toxicity [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…An effective, inexpensive, and environmentally friendly method of forming silver-containing nanocomposites is thermochemical reduction of silver ions. Still, this method sometimes requires the heating of the films at fairly high temperatures [6,18]. Recently, the method of obtaining silver-containing nanocomposites by reduction of Ag + ions in the presence of polymeric stabilizers using plant extracts (green synthesis) has become widespread [24,25].…”

Section: Introductionmentioning

confidence: 99%

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Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide

et al. 2022

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Green synthesis of silver-containing nanocomposites based on polylactide (PLA) was carried out in two ways. With the use of green tea extract, Ag+ ions were reduced to silver nanoparticles with their subsequent introduction into the PLA (mechanical method) and Ag+ ions were reduced in the polymer matrix of PLA-AgPalmitate (PLA-AgPalm) (in situ method). Structure, morphology and thermophysical properties of nanocomposites PLA-Ag were studied by FTIR spectroscopy, wide-angle X-ray scattering (WAXS), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) methods. The antimicrobial, antiviral, and cytotoxic properties were studied as well. It was found that the mechanical method provides the average size of silver nanoparticles in the PLA of about 16 nm, while in the formation of samples by the in situ method their average size was 3.7 nm. The strong influence of smaller silver nanoparticles (3.7 nm) on the properties of nanocomposites was revealed, as with increasing nanosilver concentration the heat resistance and glass transition temperature of the samples decreases, while the influence of larger particles (16 nm) on these parameters was not detected. It was shown that silver-containing nanocomposites formed in situ demonstrate antimicrobial activity against gram-positive bacterium S. aureus, gram-negative bacteria E. coli, P. aeruginosa, and the fungal pathogen of C. albicans, and the activity of the samples increases with increasing nanoparticle concentration. Silver-containing nanocomposites formed by the mechanical method have not shown antimicrobial activity. The relative antiviral activity of nanocomposites obtained by two methods against influenza A virus, and adenovirus serotype 2 was also revealed. The obtained nanocomposites were not-cytotoxic, and they did not inhibit the viability of MDCK or Hep-2 cell cultures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide

et al. 2022

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“…Nanosilver particles were reported to have a broad antibacterial effect on both Gram-negative and Gram-positive bacterial as well as antibiotic-resistant bacterial strains (Ge et al, 2014). The nanosilver technology can be applied in the manufacturing process of sanitary napkins, cotton fibers, antiseptic sprays, and antimicrobial coatings for the sterilization of medical devices (Deshmukh et al, 2019;Ge et al, 2014;Ravindra et al, 2010;Sankar et al, 2016). Other publications reported that nanosilver particles were successfully synthesized to formulate antibacterial peel-off facial masks and produce other antibacterial agents (Badnore et al, 2019;Sastry et al, 2019;Vishwasrao et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The chemical reduction method was commonly applied since it was reported as an easy, fast, and inexpensive method (Pulit et al, 2015). In the synthesis of nanosilver particles by the chemical reduction method, the usage of reducing agents may result in toxic effects and cause several environmental issues to remain (Demchenko et al, 2020;Li et al, 2011). Hence, the usage of natural reducing agents obtained from plants can be applied in the nanoparticles technology in order to decrease its toxicity and support the development of green chemistry (Li et al, 2011;Rengga et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Application of the central composite design approach for optimization of the nanosilver formula using a natural bioreductor from Camellia sinensis L. extract

Dwiastuti¹,

Suhendra²,

Yuliani³

et al. 2022

j app pharm sci

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In recent years, the interest in applying the nanosilver technology in the medical field has increased due to its benefit for microbial inactivation. A natural bioreductor was chosen and developed in the nanosilver formulation to minimize the toxicity effects. The content of rutin makes it possible to develop an alternative bioreductor agent using black tea (Camellia sinensis L.) leaves extract. The aim of this research was to optimize the nanosilver formula consisting of black tea leaf extract and AgNO 3 with the employment of central composite design. The visible absorption wavelength and transmittance percentage were observed as dependent variables. The presence of rutin in the black tea leaves extract was proved using the thin-layer chromatography (TLC) technique. It was found that the extract concentration of 2.131% (m/v) and the AgNO 3 concentration of 1.379 mM were stated as the computational recommendation resulting from the predictive model with a composite desirability value at 0.998. These optimum conditions were applied in the synthesis of six nanosilver formula replications and resulted in the percentage of a prediction relative error of absorption wavelength and transmittance which were in the ranges of 1.18%-9.18% and 2.72%-8.64%, respectively. The Relative Standard Deviation (RSD) values of absorption wavelength and transmittance were 2.81% and 2.21%, respectively. The Z-average of the nanosilver particles was 124.8 nm.

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“…However, due to toxic chemical agents used when preparing these NPs which affect their biocompatibility and pose environmental problems, biosynthesized AgNPs have been the subject of research recently. e biosynthesis of AgNPs involves a simple one-pot synthesis approach in which silver salts are reduced to fabricate AgNPs using nontoxic and natural polymers such as bacterial biomass, chitosan, and carbohydrates (e.g., starch) as both reducing and stabilizing agents [13,14].…”

Section: Introductionmentioning

confidence: 99%

Anticancer and Antimicrobial Activity Evaluation of Cowpea-Porous-Starch-Formulated Silver Nanoparticles

Ramdath

Mellem

Mbatha

2021

Journal of Nanotechnology

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Health issues involving inadequate treatment of diseases such as cancer and microbial infections continue to be the subject of much ongoing recent research. Biosynthesized silver nanoparticles (AgNPs) were characterized using Transmission Electron Microscopy (TEM), Zeta Sizer, Ultraviolet (UV), and Fourier Transform Infrared (FTIR) spectroscopy. Their antimicrobial activity was evaluated on selected Gram-positive and Gram-negative bacterial strains, using the disc diffusion and broth dilution assays. Cell viability profiles were evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and apoptosis studies on selected human noncancer and cancer cells. The biosynthesized AgNPs were evaluated to be spherical clusters, with sizes between 40 and 70 nm. The absorption peak at 423 nm and the presence of polyphenols confirmed the synthesis and stabilization of these tested AgNPs. The AgNPs showed a good stability of −23.9 ± 1.02 mV. Good antimicrobial activity (6.0–18.0 mm) was seen on all tested bacteria at a minimum inhibitory concentration (MIC) ranging from 5 to 16 μg/ml, with the highest activity seen against Gram-negative Escherichia coli (18 ± 0.5 mm), and the lowest activity was seen against Gram-positive Listeria monocytogenes (6.0 ± 0.4 mm) after treatment with the AgNPs. These NPs showed a concentration-dependent and cell-specific cytotoxicity with low IC50 values (41.7, 56.3, and 63.8 μg/ml). The NPs were well tolerated by tested cells as indicated by a more than 50% cell viability at the high dose tested and low apoptotic indices (<0.2). These findings indicated that these biosynthesized AgNPs showed great potential as effective antibacterial agents and anticancer drug delivery modalities.

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Novel approach to synthesis of silver nanoparticles in interpolyelectrolyte complexes based on pectin, chitosan, starch and their derivatives

Cited by 33 publications

References 31 publications

Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide

Structure-Morphology-Antimicrobial and Antiviral Activity Relationship in Silver-Containing Nanocomposites Based on Polylactide

Application of the central composite design approach for optimization of the nanosilver formula using a natural bioreductor from Camellia sinensis L. extract

Anticancer and Antimicrobial Activity Evaluation of Cowpea-Porous-Starch-Formulated Silver Nanoparticles

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