Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants

Nierenberg, Jovia L.; He, Jiang; Li, Changwei; Gu, Xiaoqing; Shi, Mengyao; Razavi, Alexander C.; Mi, Xuenan; Li, Shengxu; Bazzano, Lydia A.; Anderson, Amanda H.; He, Hua; Chen, Wei; Kinchen, Jason M.; Rebholz, Casey M.; Coresh, Josef; Levey, Andrew S.; Inker, Lesley A.; Shlipak, Michael G.; Kelly, Tanika N.

doi:10.1007/s11306-019-1613-3

Cited by 15 publications

(17 citation statements)

References 54 publications

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“…The metabolites inversely associated with physical performance were all also associated with kidney function in our previous study in the BHS, with consistent effect direction [18]. These metabolites are presented in Supplementary Table 6, along with lookups of their associations with aging, inflammation, and mortality in previous research.…”

Section: Overlap With Kidney Function Metabolitessupporting

confidence: 67%

“…Interestingly, all of the metabolites with inverse associations with physical performance measures were also inversely associated with kidney function in the BHS [18]. Many of these metabolites were also associated with kidney function in other populations [27,[34][35][36][37].…”

Section: Kidney Function and Agingmentioning

confidence: 90%

“…To account for potential confounding by clinical factors, we conducted a sensitivity analysis with adjustment for fasting glucose, systolic blood pressure, and low-density lipoprotein, in addition to the covariates from the main analysis. We additionally examined the overlap in significant findings between this study and the findings of our previous kidney function metabolomics publication in the BHS [18].…”

Section: Association Of Single Metabolites With Physical Performance Phenotypesmentioning

confidence: 94%

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Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study

Nierenberg

et al. 2020

Aging

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Age-related declines in physical performance predict cognitive impairment, disability, chronic disease exacerbation, and mortality. We conducted a metabolome-wide association study of physical performance among Bogalusa Heart Study participants. Bonferroni corrected multivariate-adjusted linear regression was employed to examine cross-sectional associations between single metabolites and baseline gait speed (N=1,227) and grip strength (N=1,164). In a sub-sample of participants with repeated assessments of gait speed (N=282) and grip strength (N=201), significant metabolites from the cross-sectional analyses were tested for association with change in physical performance over 2.9 years of follow-up. Thirty-five and seven metabolites associated with baseline gait speed and grip strength respectively, including six metabolites that associated with both phenotypes. Three metabolites associated with preservation or improvement in gait speed over follow-up, including: sphingomyelin (40:2) (P=2.6×10 -4 ) and behenoyl sphingomyelin (d18:1/22:0) and ergothioneine (both P<0.05). Seven metabolites associated with declines in gait speed, including: 1-carboxyethylphenylalanine (P=8.8×10 -5 ), and N-acetylaspartate, N-formylmethionine, S-adenosylhomocysteine, N-acetylneuraminate, N2,N2-dimethylguanosine, and gamma-glutamylphenylalanine (all P<0.05). Two metabolite modules reflecting sphingolipid and bile acid metabolism associated with physical performance (minimum P=7.6×10 -4 ). These results add to the accumulating evidence suggesting an important role of the human metabolome in physical performance and specifically implicate lipid, nucleotide, and amino acid metabolism in early physical performance decline.

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Section: Overlap With Kidney Function Metabolitessupporting

confidence: 67%

Section: Kidney Function and Agingmentioning

confidence: 90%

Section: Association Of Single Metabolites With Physical Performance Phenotypesmentioning

confidence: 94%

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Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study

Nierenberg

et al. 2020

Aging

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“…In these persons, concomitant consumption of bezafibrate may reduce oxidation (da Rosa-Junior et al 2020). As well, HMGA is largely metabolized in the kidney and excess plasma levels of HMGA may be an indicator of early-stage renal dysfunction (Nierenberg et al 2019) so again HMGA would not be appropriate for such individuals with an HMG-CoA lyase deficiency. Milajerdi et al (2020), in a review paper indicated that Atorvastatin and Simvistatin in T2D patients could decrease the generalized inflammatory marker (serum C-reactive protein, CRP) with Atorvastatin possibly reducing serum interleukin-6 (IL-6), the principal inducer of the CRP gene (Volanakis 2001).…”

Section: Pro-thrombosismentioning

confidence: 99%

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes

Barre

Mizier-Barre

2021

Endocrine Regulations

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Objectives. This review assesses the comparative safety and efficacy of selected 3-hydroxy-3-methylglutaric acid coenzyme A inhibitors (statins, cinnamic acids. 3-hydroxy-3-methyl glutaric acid) on the pre-onset type 2 diabetes (PT2D) and post-onset type 2 diabetes (T2D)-related cluster of seven features (central obesity, hyperglycemia, hypertension, dyslipidemia, pro-thrombosis, oxidation and inflammation). Methods. Google scholar and PubMed were searched for statin*, flaxseed lignan complex (FLC), cinnamic acid (CA)*, and 3-hydroxy-3-methylglutaric acid (HMGA) in conjunction with each of PT2D, T2D and the cluster of seven. An introduction was followed by findings or absence thereof on the impacts of each of statins, FLC, CAs and HMGA on each member of the cluster of seven. Results. Pravastatin manages three features in PT2D, while a number of the statins improve five in T2D. FLC is negative in PT2D but controls four in T2D; it is not clear if the CAs and HMGA in FLC play a role in this success. CAs have potential in six and HMGA has potential in three of the cluster of seven though yet CAs and HMGA are untested in PT2D and T2D in humans. There are safety concerns with some statins and HMGA but FLC and CAs appear safe in the doses and durations tested. Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.

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“…Studies have shown increased levels of circulating metabolites in CKD [2][3][4] and association of metabolites with estimated glomerular filtration rate (eGFR). [5][6][7][8][9][10] Additional research has shown that some metabolites are extracted or released in the blood as part of intrarenal metabolism such as for renal gluconeogenesis and ammoniagenesis. 8,11 Therefore, kidney function is only one of the mechanisms accounting for circulating metabolites levels.…”

Section: Introductionmentioning

confidence: 99%

Metabolome-wide association study of estimated glomerular filtration rates in Hispanics

Lin

Zhang

et al. 2022

Kidney International

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Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants

Cited by 15 publications

References 54 publications

Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study

Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study

Selected 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors. A look into their use and potential in pre-diabetes and type 2 diabetes

Metabolome-wide association study of estimated glomerular filtration rates in Hispanics

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