Novel Bioceramics for Bone Implants

Gouma, Pelagia‐Irene; Ramachandran, Koushik; Fırat, Murat; Connolly, Michael D.; Zuckermann, Ronald N.; Balaszi, Cs.; Perrotta, Peter L.; Xue, R.

doi:10.1002/9780470584354.ch4

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…CA nanofibers have been increasingly used in tissue engineering. 18,20,21 An ultrafine CA/chitosan scaffold has been reported in which the bulk mechanical properties were better than a single polymer scaffold without affecting biocompatibility. 22 The structures of Zein and CA are given in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Zein/cellulose acetate hybrid nanofibers: Electrospinning and characterization

et al. 2014

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Protein based scaffolds are preferred for tissue engineering and other biomedical applications owing to their unique properties. Zein, a hydrophobic protein, is a promising natural biodegradable polymer. However, electrospun structures prepared from Zein have poor mechanical and wetting properties. Cellulose acetate (CA) is an economical, biodegradable polymer having good mechanical and water retention properties. The aim of present study was to fabricate a novel material by electrospinning Zein/CA blends. A series of Zein/CA hybrid nanofibers were electrospun and characterized. The attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) spectrum showed the characteristic peaks of both Zein and CA, and was composition dependent. The X-ray photoelectron spectrometry (XPS) curves of Zein/CA blends demonstrated a similar profile to that of pristine Zein nanofibers. Thermogravimetric analyser (TGA) studies confirmed that the Zein/CA hybrid nanofibers have a higher degradation temperature and better thermal stability than pristine Zein nanofibers. The glass transition temperature (T g ) of Zein/CA hybrid nanofibers was also increased in comparison to pure Zein nanofibers as revealed by differential scanning calorimetry (DSC). Zein/CA hybrid nanofibers have hydrophilic surface character as revealed by water contact angle (WCA) analysis. SEM imaging showed bead free morphology of the electrospun nanofibers. The average nanofiber diameter decreased for Zein/CA blends with increasing CA composition. The electrospun Zein/CA hybrid nanofibers may be used for tissue engineering scaffolds and for other biomedical materials.

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Section: Introductionmentioning

confidence: 99%

Zein/cellulose acetate hybrid nanofibers: Electrospinning and characterization

et al. 2014

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“…However, biomaterial activity is still one key factor in designing an artificial bioscaffold (Kakisis et al 2005). To achieve that aim, numerous methods have been carried out (Ma et al 2005;Gouma et al 2010;Wu et al 2011;Truong et al 2012;Wang et al 2012). Among these methods, loading specific particulates was thought to be a facile one.…”

Section: Introductionmentioning

confidence: 99%

Effect of microcrystal cellulose and cellulose whisker on biocompatibility of cellulose-based electrospun scaffolds

Jia

Yang

et al. 2013

Cellulose

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To investigate the potential application of microcrystal cellulose (MCC) and cellulose whisker (CW) in the electrospun vascular tissue scaffolds, cellulose acetate (CA) and cellulose composite scaffolds containing MCC and CW were electrospun from CA solutions and deacetylation. Structure and morphology of MCC, CW and the fibrous composite scaffolds were investigated using FT-IR, SEM, TEM and AFM. The wettability of the scaffolds was evaluated by water contact angle analysis. The effect of MCC and CW on the biocompatibility of the scaffolds for vascular smooth muscle cells (VSMC) was assayed by MTT test, fluorescent imaging and SEM. The biocomposite scaffolds displayed multiscaled structure and morphology. The scaffolds containing MCC and CW simultaneously exhibited significantly higher cell viability compared to those with only MCC or CW and no filler. Cell viability and morphology within the scaffolds become better with increasing content of MCC and CW. The composite scaffolds with both micro-and nano-scale organization could mimic the native extracellular matrix more closely, and further produce synergistic enhancement on VSMC viability, adhesion and proliferation. This study provides the potential applications of renewable cellulose-based particulates in biomedical field.

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“…Other parameters such as viscosity, surface tension, conductivity, dielectric constant may be modified by selecting the appropriate polymer. The others parameters may be modified directly: flow rate, voltage, diameter of the needle and the distance between the needle and the target [4].…”

Section: Methodsmentioning

confidence: 99%

Production of Polymer Nanofibers Containing Hydroxyapatite by Electrospinning

Tóth

Gergely

Lukács

et al. 2010

MSF

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Hydroxyapatite (HAP) is the main inorganic component of mammal bone and teeth. It is one of the few bioactive materials, which helps cell growing. The objective of this study was to fabricate hydroxyapatite-biopolimer nanofiber mats. To achieve this goal, two different suspensions were used. Approximately 1 μm diameter size fibers with large HAP agglomerates were fabricated using acetone and acetic acid. Fibers with a larger diameter size and homogenous distributed HAP particles were produced applying acetone and isopropanol. During the experiment the effect of the processing parameters: applied voltage, diameter of needle, the distance of the needle tip and the collector, flow rate was analyzed.

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Novel Bioceramics for Bone Implants

Cited by 4 publications

References 18 publications

Zein/cellulose acetate hybrid nanofibers: Electrospinning and characterization

Zein/cellulose acetate hybrid nanofibers: Electrospinning and characterization

Effect of microcrystal cellulose and cellulose whisker on biocompatibility of cellulose-based electrospun scaffolds

Production of Polymer Nanofibers Containing Hydroxyapatite by Electrospinning

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