Novel biodegradable heparin-coated nanocomposite system for targeted drug delivery

Javid, Amaneh; Ahmadian, Shahin; Saboury, Ali Akbar; Kalantar, Seyed Mehdi; Rezaei‐Zarchi, Saeed

doi:10.1039/c3ra43967d

Cited by 25 publications

(19 citation statements)

References 38 publications

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“…18 Positively charged stabilised iron oxide particles, on the other hand, have been shown to have a higher cytotoxic effect on cells and animal models than negatively charged analogues. 21 Some reports of heparin-stabilised magnetic nanoparticles have demonstrated their usefulness in the labelling of human mesenchymal stem cells and cell tracking, 22 drug delivery, 23,24 labelling and imaging of pancreatic islets, 25 with some of these demonstrating excellent T 2 -weighted (in vivo) MRI of tissues and cells, [26][27][28] indicating that such stabilised systems are promising as MRI CAs. There have not, however, been any studies to date which describe in detail the importance of precise composition of the magnetic fluid (in terms of molar reactant ratios) on their magnetic resonant properties.…”

Section: Introductionmentioning

confidence: 99%

Heparin-stabilised iron oxide for MR applications: a relaxometric study

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Heparin-stabilised iron oxide for MR applications: a relaxometric study

et al. 2016

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“…1 Magnetic resonance imaging, 2-4 hyperthermia [5][6][7] and drug delivery [8][9][10][11][12] are some of the practical applications displayed by SPIONs. These nanomaterials are promising due to the biocompatibility of the iron oxide cores, e.g., magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ).…”

Section: Introductionmentioning

confidence: 99%

Studies of the Colloidal Properties of Superparamagnetic Iron Oxide Nanoparticles Functionalized with Platinum Complexes in Aqueous and PBS Buffer Media

Silva

Marciello

Morales

et al. 2016

J. Braz. Chem. Soc.

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This work has focused on the synthesis of three nanosystems composed of superparamagnetic iron oxide nanoparticles (SPIONs) coated either with a carboxylate platinum(IV) complex (PD = cis,cis, ) 2 Cl 2 (HOOCCH 2 CH 2 COO)(OH)]) or with platinum(II) complex functionalized dextrans (DexPt1 = [Pt(Dex-NH 2 )Cl 3 ] and DexPt2 = [Pt(Dex-NH 2 )(NH 3 ) 2 (H 2 O)]). All nanosystems have shown superparamagnetic behavior. Powder X-ray diffraction (XRD) has confirmed that the SPIONs were iron oxide phase and transmission electron microscopy (TEM) has shown average size of 6 nm (M6). Characterization of the nanosystems by inductively coupled plasma atomic emission spectroscopy (ICP AES) has revealed the presence of platinum on their surface (M6@PD, 0.54 mmol g -1 of Fe and M6@CA@DexPt1-2, 0.32-1.20 mmol g -1 of Fe); infrared spectroscopy (IR) and thermogravimetric and differential thermal analyses (TG-DTA) have confirmed the presence of dextran. Furthermore, the colloidal properties of these nanosystems (M6@PD and M6@CA@DexPt1-2) have been evaluated in water and in PBS buffer. Although M6@PD has shown good colloidal dispersion in water in the pH range of 2.0-8.0, the system underwent rapid agglomeration in PBS buffer. The M6@CA@DexPt1-2 nanosystems have exhibited improved colloidal behavior both in water and in PBS, where hydrodynamic sizes were kept below 100 nm over a large pH range (2.0-12.0). Furthermore, the latter systems have displayed isoelectric points below pH 5.0 and low surface charges at pH 7.0 (ζ-potential = −10 mV) and therefore PBS did not affect their colloidal stability.Keywords: colloidal stability, dextran, iron oxide, platinum complexes, superparamagnetism IntroductionSuperparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated for biomedical purposes. Magnetic resonance imaging, 2-4 hyperthermia 5-7 and drug delivery [8][9][10][11][12] are some of the practical applications displayed by SPIONs. These nanomaterials are promising due to the biocompatibility of the iron oxide cores, e.g., magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ). 13 Furthermore, their surfaces can be easily modified, allowing for the tuning of pharmacokinetic properties. [14][15][16] One of the key features for biomedical applications of SPIONs is their aqueous colloidal stability. 17 Therefore, surface functionalization plays a relevant role on the balance of attractive forces, such as dispersion forces and dipole-dipole interactions that determine their agglomeration.18 Carboxylate-, phosphonate-and aminosilane-based derivatives have been widely used to coat SPIONs in order to prevent aggregation, mainly by electrostatic interactions due to the formation of an electrical double layer. [16][17][18][19] However, this kind of colloidal dispersion is strongly affected by physiological pH and ionic strength. 17 Coating nanoparticles with polymers, such as dextran (Dex) or poly(ethylene glycol) (PEG), is a judicious strategy to prevent SPIONs from aggregation, 13,20 diminishing opsonization and increasing circulat...

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“…Drug-laden silk fibroin magnetic nanoparticles have been used in cancer research to access tumor sites [138,162]. Various polysaccharides such as heparin and chitosan have been used with superparamagnetic iron oxides in the delivery of anticancer drugs and for tumor tagging capabilities [18,80,83].…”

Section: Drug Deliverymentioning

confidence: 99%

Protein and Polysaccharide-Based Magnetic Composite Materials for Medical Applications

Bealer

Kavetsky

Dutko

et al. 2019

IJMS

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The combination of protein and polysaccharides with magnetic materials has been implemented in biomedical applications for decades. Proteins such as silk, collagen, and elastin and polysaccharides such as chitosan, cellulose, and alginate have been heavily used in composite biomaterials. The wide diversity in the structure of the materials including their primary monomer/amino acid sequences allow for tunable properties. Various types of these composites are highly regarded due to their biocompatible, thermal, and mechanical properties while retaining their biological characteristics. This review provides information on protein and polysaccharide materials combined with magnetic elements in the biomedical space showcasing the materials used, fabrication methods, and their subsequent applications in biomedical research.

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Novel biodegradable heparin-coated nanocomposite system for targeted drug delivery

Cited by 25 publications

References 38 publications

Heparin-stabilised iron oxide for MR applications: a relaxometric study

Heparin-stabilised iron oxide for MR applications: a relaxometric study

Studies of the Colloidal Properties of Superparamagnetic Iron Oxide Nanoparticles Functionalized with Platinum Complexes in Aqueous and PBS Buffer Media

Protein and Polysaccharide-Based Magnetic Composite Materials for Medical Applications

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