Novel biomimetic thermosensitive β‐tricalcium phosphate/chitosan‐based hydrogels for bone tissue engineering

Dessì, M.; Borzacchiello, Assunta; Mohamed, Tawheed; Abdel-Fattah, Wafa I.; Ambrosio, Luigi

doi:10.1002/jbm.a.34592

Cited by 93 publications

(56 citation statements)

References 71 publications

(226 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chitosan is another commonly used biomaterial for synthesizing injectable hydrogels in bone tissue engineering. 274 Dessi et al 275 have successfully developed a thermosensitive chitosan-based hydrogel cross-linked with β-glycerophosphate and reinforced by physical interactions with β-tricalcium phosphate. The hydrogel simulates natural bone tissue and supports cellular activity and undergoes a sol–gel transition at physiological temperature with typical rheological properties.…”

Section: Injectable Hydrogels For Bone Tissue Engineeringmentioning

confidence: 99%

Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

View full text Add to dashboard Cite

Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

show abstract

Section: Injectable Hydrogels For Bone Tissue Engineeringmentioning

confidence: 99%

Injectable hydrogels for cartilage and bone tissue engineering

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This has previously been demonstrated in mesenchymal stem cell differentiation [15]. For example, it has been shown that engineering of bone tissue requires a strong and relatively stiff gel [16]. Conversely, the engineering of tissues such as cardiac or corneal tissue requires a matrix to exhibit a much more soft and elastic environment [17] [18].…”

Section: Introductionmentioning

confidence: 99%

Controlling the rheology of gellan gum hydrogels in cell culture conditions

Moxon

Smith

2016

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Successful culturing of tissues within polysaccharide hydrogels is reliant upon specific mechanical properties. Namely, the stiffness and elasticity of the gel have been shown to have a profound effect on cell behaviour in 3D cell cultures and correctly tuning these mechanical properties is critical to the success of culture. The usual way of tuning mechanical properties of a hydrogel to suit tissue engineering applications is to change the concentration of polymer or its cross-linking agents. In this study sonication applied at various amplitudes was used to control mechanical properties of gellan gum solutions and gels. This method enables the stiffness and elasticity of gellan gum hydrogels cross-linked with DMEM to be controlled without changing either polymer concentration or cross-linker concentration. Controlling the mechanical behaviour of gellan hydrogels impacted upon the activity of alkaline phosphatase (ALP) in encapsulated MC3T3 pre-osteoblasts. This shows the potential of applying a simple technique to generate hydrogels where tissue-specific mechanical properties can be produced that subsequently influence cell behaviour.

show abstract

“…Dessi et al developed a thermosensitive β-tricalcium phosphate-chitosan hydrogel in the presence of β-GP and glyoxal to impart physical and chemical gelations. The presence of β-tricalcium phosphate in the in situ-gelling hydrogel showed to significantly increase cell attachment and proliferation [96]. For enhancing bone repair and regeneration, drug and growth factors can also be incorporated in hydrogels for localized delivery.…”

Section: Orthopedic Regenerative Engineeringmentioning

confidence: 97%

Chitosan Hydrogels for Regenerative Engineering

Padmanabhan

Nair

2015

Springer Series on Polymer and Composite Materials

View full text Add to dashboard Cite

Research in the field of hydrogels has been actively growing for the past couple of decades. Hydrogels are crosslinked polymers with high water content. They can be prepared from natural, synthetic, and composite polymers using different chemical and physical crosslinking methods. Hydrogels have been widely explored for the delivery of bioactive molecules, drugs, and for other therapeutic applications. Chitosan-based hydrogels have unique advantages owing to their biocompatibility, biodegradability, antimicrobial activity, mucoadhesivity, and low toxicity. This chapter reviews the different methods used for preparing chitosan-based hydrogels and their applications as cell, protein, and drug delivery vehicles to support tissue regeneration.

show abstract

Novel biomimetic thermosensitive β‐tricalcium phosphate/chitosan‐based hydrogels for bone tissue engineering

Cited by 93 publications

References 71 publications

Injectable hydrogels for cartilage and bone tissue engineering

Injectable hydrogels for cartilage and bone tissue engineering

Controlling the rheology of gellan gum hydrogels in cell culture conditions

Chitosan Hydrogels for Regenerative Engineering

Contact Info

Product

Resources

About