Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications

Dev, Ashish; Mohan, Jithin C.; Sreeja, V.; Tamura, Hiroshi; Patzke, Greta R.; Hussain, Firasat; Weyeneth, S.; Nair, Shantikumar V.; Jayakumar, R.

doi:10.1016/j.carbpol.2009.10.038

Cited by 129 publications

(48 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7). As the surrounding of tumor mass has a slightly acidic pH around 6.8, it is significative to study how the drug release profiles progress at this particular pH [29]. The in vitro cumulative release profiles of MTX from FA-CS nanoparticles with different drug-to-polymer ratios (from 1:20 to 4:20) are shown in Fig.…”

Section: Characterization Of Fa-cs Nanoparticlesmentioning

confidence: 99%

Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery

Ji¹,

Wu²,

Liu³

et al. 2011

Polym. Bull.

View full text Add to dashboard Cite

To reduce the toxicity of methotrexate (MTX) and increase the targeting of nanoparticles, the MTX-loaded chitosan (CS) covalently bonded with folic acid (FA) nanoparticles were prepared, and sodium tripolyphosphate was used as the cross-linking agent. FA was successfully conjugated to CS confirmed by 1 H-NMR and Fourier transform infrared spectrometer (FT-IR). The prepared FA-CS nanoparticles were characterized by FT-IR spectroscopy to confirm the cross-linking reaction between FA-CS and cross-linking agent. X-ray diffraction was performed to reveal the crystalline nature of the drug after encapsulation. The average diameters of the nanoparticles ranged from 293.9 ± 24.2 to 401.5 ± 20.4 nm with a narrow particle size distribution. In vitro release pattern in phosphate buffer saline (pH 6.8) indicated that the characteristics of the MTX-loaded nanoparticles appeared to have an initial burst effect and followed by a slow, sustained drug release. FA or low molecular weight FA conjugate fragments were also released from the nanoparticles, which might have potential to reduce toxic effects of MTX within the body.

show abstract

Section: Characterization Of Fa-cs Nanoparticlesmentioning

confidence: 99%

Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery

Ji¹,

Wu²,

Liu³

et al. 2011

Polym. Bull.

View full text Add to dashboard Cite

show abstract

“…Because of its biocompatibility and biodegradation properties (Bernkop-Schnürch, Schwarz, & Steininger, 1999;Jayakumar, Chennazhi, et al, 2010;Jayakumar, Deepthy, Manzoor, Nair, & Tamura, 2010;Jayakumar, Nwe, Tokura, & Tamura, 2007;Jayakumar, Prabaharan, Nair, Tokura, et al, 2010;Jayakumar, Reis, & Mano, 2007), it has been used in a variety of biomedical applications. A number of clinical studies using chitosan have been reported including its use as cell scaffolds in tissue engineering, nerve regeneration tubes, cartilage regeneration (Freier, Koh, Kazazian, & Shoichet, 2005;Khor and Lim, 2003;VandeVord , 2002) and also in drug delivery applications (Anitha et al, 2009;Dev, Binulal, et al, 2010;Dev, Jithin, et al, 2010;Jayakumar, Chennazhi, et al, 2010;Jayakumar, Deepthy, et al, 2010;Jayakumar, Prabaharan, Nair, Tokura, et al, 2010;Jayakumar, Nwe, et al, 2007;Jayakumar, Prabaharan, Reis, & Mano, 2005;Jayakumar, Reis, & Mano, 2006;Mathew et al, 2010). Furthermore, it has been used extensively as a biomaterial, owing to its immunostimulatory activities (Mwale et al, 2005), anticoagulant properties, antimicrobial and antifungal action (Gorbach et al, 1994;Rabea, Badawy, Stevens, Smagghe, & Steubaut, 2003) and for its action as a promoter of wound healing in the field of surgery (Madhumathi et al, 2010;Sudheesh Kumar et al, 2010;Wang, Du, Fan, Liu, & Hu, 2005) and in a number of pharmaceutical preparations, primarily for the purpose of controlled drug delivery (Felt, Buri, & Gurny, 1998;Khan, Peh, & Chng, 2000) such as, mucosal (Freier et al, 2005;…”

Section: Introductionmentioning

confidence: 99%

Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications

Anitha

Deepa

Chennazhi

et al. 2011

Carbohydrate Polymers

Self Cite

166

View full text Add to dashboard Cite

“…The functions of CMchitosan on the wound healing are not fully known yet [11][12][13]. CM-chitosan nanoparticles can be easily formed through simple ionic gelification [14][15][16]. Compared with CMchitosan solution, CM-chitosan nanoparticles also have antibacterial activity and nontoxicity.…”

Section: Introductionmentioning

confidence: 96%

The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

et al. 2011

View full text Add to dashboard Cite

In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW 6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

show abstract

Novel carboxymethyl chitin nanoparticles for cancer drug delivery applications

Cited by 129 publications

References 29 publications

Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery

Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery

Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications

The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

Contact Info

Product

Resources

About