Novel carvedilol paediatric nanomicelle formulation: in-vitro characterization and in-vivo evaluation

Abstract

The present investigation demonstrates the development of highly concentrated CAR liquid micellar formulation. The improvement on drug oral bioavailability contributes to the potential of this NMs formulation to enhance CAR paediatric treatment.

In situ misemgel as a multifunctional dual-absorption platform for nasal delivery of raloxifene hydrochloride: formulation, characterization, and in vivo performance

“…[15][16][17] Recently, an aqueous-soluble form of natural vitamin E, known as d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), has gained attention as a promising pharmaceutical excipient for developing amphiphilic micelles (alone or mixed with other biomaterials) and are capable of encapsulating hydrophobic drugs. 18,19 Nasal drug administration has attracted considerable attention in the field of drug delivery due to the distinct advantages that it can offer. These advantages include the avoidance of presystemic metabolism and rapid absorption when compared to the oral route, owing to the rich vasculature of the nasal mucosa.…”

Self-nanomicellizing solid dispersion of edaravone: part I – oral bioavailability improvement

“… 56 The micellar system of SOL showed dramatic improvement in oral BA of drugs such as quercetin 56 and cyclosporine A 43 and the therapeutic efficacy of drugs such as doxorubicin, 62 α-lipoic acid, 63 and carvedilol. 64 Thus, the self-nanomicellizing properties of NEF after dissolving NEF in aqueous media were investigated. The particle size is the most critical parameter as <100 nm could enhance cellular uptake of drugs and also facilitate the transport across the intestinal membrane by paracellular or transcellular routes.…”

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

“…Compared to conventional surfactants, Soluplus ® produces smaller spherical micelles (70-100 nm), with a hydrophobic core-hydrophilic shell structure that can help solubilizing poorly soluble compounds. The spherical structure of these nanomicelles reduces the free energy of the system and can aid for the production of highly water-soluble formulations [79][80][81][82][83]. The aim of this study was to prepare Soluplus ® micelles to enhance the solubility of three model APIs belonging to class II of the Biopharmaceutics Classification System (BCS), i.e., characterized by a poor solubility and a good permeability profile: ibuprofen (Ib), idebenone (Id) and miconazole (Mc).…”

“…Compared to conventional surfactants, Soluplus ® produces smaller spherical micelles (70-100 nm), with a hydrophobic core-hydrophilic shell structure that can help solubilizing poorly soluble compounds. The spherical structure of these nanomicelles reduces the free energy of the system and can aid for the production of highly water-soluble formulations [79][80][81][82][83].…”