Novel catalytic micromotor of porous zeolitic imidazolate framework-67 for precise drug delivery

Wang, Linlin; Zhu, Hongli; Shi, Ying; Ge, You; Feng, Xiang; Liu, Ruiqing; Li, Yang; Ma, Yanwen

doi:10.1039/c8nr02493f

Cited by 105 publications

(67 citation statements)

References 48 publications

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“…ZIF-67/Fe 3 O 4 /DOX was obtained by a simple method, which could be targeted to the tumor tissue under the action of an external magnetic field. Then the drug-loading system released the drugs under the action of H 2 O 2 catalysis and water effect [92]. This versatile MOFs nano-platform could not only perform excellent positioning functions, but also improve the therapeutic effect together with chemotherapy.…”

Section: Multi-targeted Response Of Mof Nanomaterials For Anticancer Tmentioning

confidence: 99%

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

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In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

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Section: Multi-targeted Response Of Mof Nanomaterials For Anticancer Tmentioning

confidence: 99%

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

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“…To meet these demands of efficient energy harvesting and conversion, a wide variety of fabrication strategies have been developed, such as metallic thin films deposition, templateassistant metal electroplating, rolling-up methods, and selfassembly techniques [31,32]. With these techniques, a broad array of micro/nanomotors have been fabricated, such as nanowires [33][34][35], microtubular microrockets [36][37][38], Janus microspheres [39][40][41], and supermolecule-based nanomotors [42][43][44]. They can efficiently be moved by harnessing various fuels and various driving modes [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

et al. 2019

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HIGHLIGHTS• Recent advances of micro/nanomotors in the field of cancer-targeted delivery, diagnosis, and imaging-guided therapy are summarized.• Challenges and outlook for the future development of micro/nanomotors toward clinical applications are discussed.ABSTRACT Micro/nanomotors have been extensively explored for efficient cancer diagnosis and therapy, as evidenced by significant breakthroughs in the design of micro/nanomotors-based intelligent and comprehensive biomedical platforms. Here, we demonstrate the recent advances of micro/nanomotors in the field of cancer-targeted delivery, diagnosis, and imaging-guided therapy, as well as the challenges and problems faced by micro/nanomotors in clinical applications. The outlook for the future development of micro/nanomotors toward clinical applications is also discussed. We hope to highlight these new advances in micro/nanomotors in the field of cancer diagnosis and therapy, with the ultimate goal of stimulating the successful exploration of intelligent micro/nanomotors for future clinical applications.

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“…However, poor drug adsorption capability of calcium phosphate needs to be solved urgently. Generally, the approaches of drug molecules immobilizing over the surface of carrier depend on the surface properties containing surface potential [20], hydrophobicity/hydrophilicity [21], hydrogen bond [22], and specific surface area [23]. So, improving surface properties and specific surface area is a valid approach for ehancing drug adsorption capability of carrier.…”

Section: Introductionmentioning

confidence: 99%

Organic Phosphorous and Calcium Source Induce the Synthesis of Yolk-Shell Structured Microspheres of Calcium Phosphate with High-Specific Surface Area: Application in HEL Adsorption

Cao¹,

Wang²,

Wang

et al. 2020

Nanoscale Res Lett

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Yolk-shell-structured calcium phosphate microspheres have a great potential for medical applications due to their excellent physicochemical properties and biocompatibility. However, developing a yolk-shell-structured calcium phosphate with high adsorption capability remains a challenge. Herein, a porous yolk-shell-structured microsphere (ATP-CG) of calcium phosphate with high-specific surface area [S BET = 143 m 2 g −1 , which is approximately three times as high as that of ATP-CL microspheres synthesized by replacing calcium source with calcium L-lactate pentahydrate (CL)] was successfully synthesized by using adenosine 5'-triphosphate disodium salt (ATP) as the phosphorous source and calcium gluconate monohydrate (CG) as calcium source through a self-templating approache. The influences of molar ratio of Ca to P (Ca/P), hydrothermal temperature, and time on the morphology of ATP-CG microspheres were also investigated. It is found that the organic calcium source and organic phosphorous source play a vital role in the formation of yolk-shell structure. Furthermore, a batch of adsorption experiments were investigated to illuminate the adsorption mechanism of two kinds of yolk-shell-structured microspheres synthesized with different calcium sources. The results show that the adsorption capacity of ATP-CG microspheres (332 ± 36 mg/g) is about twice higher than that of ATP-CL microspheres (176 ± 33 mg/g). Moreover, the higher-specific surface area caused by the calcium source and unique surface chemical properties for ATP-CG microspheres play an important role in the improvement of HEL adsorption capability. The study indicates that the as-prepared yolk-shell-structured microsphere is promising for application in drug delivery fields and provides an effective approach for improving drug adsorption capability.

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Novel catalytic micromotor of porous zeolitic imidazolate framework-67 for precise drug delivery

Cited by 105 publications

References 48 publications

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

Organic Phosphorous and Calcium Source Induce the Synthesis of Yolk-Shell Structured Microspheres of Calcium Phosphate with High-Specific Surface Area: Application in HEL Adsorption

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