Novel cation-exchange stationary phase for the separation of amines and of six common inorganic cations

Rey, María; Pohl, Christopher A.

doi:10.1016/0021-9673(96)00042-8

Cited by 57 publications

(33 citation statements)

References 5 publications

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“…Except for the two carboxylic acids, within each category of solute, the enthalpy changes is more exothermic for the more retained solutes. This agrees with the results of Rey [51] and Paull [52] in their study of metal ion separations on polymer-based cation-exchangers [51,52].…”

Section: 13supporting

confidence: 82%

“…For example, with comparable retention, compound 4 (an amino acid with partial positive charge, ΔH° = −3.61 kJ/mol) has a much bigger enthalpy change than compound 5 (a base with one positive charge, ΔH° = −0.84 kJ/mol). Similar differences in enthalpy changes were also observed in studies on the ion exchange of monovalent and divalent metal cations, where divalent cations show much weaker dependence of retention on temperature than monovalent cations [51][52][53][54].…”

supporting

confidence: 58%

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Application of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases for separating highly hydrophilic basic compounds

Luo

Paek

et al. 2008

Journal of Chromatography A

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The separation and determination of hydrophilic basic compounds are of great importance in many fields including clinical and biological research, pharmaceutical development and forensic analysis. However, the most widely used analytical separation technique in these disciplines, reversed-phase liquid chromatography (RPLC), usually does not provide sufficient retention for several of the important classes of highly hydrophilic basic compounds including catecholamines, many drug metabolites and many drugs of abuse. Commonly eluents having little or no organic modifier and/ or strong ion pairing agents must be used to achieve sufficient retention and separation. Use of highly aqueous eluents can lead to column failure by dewetting, resulting in poor retention, selectivity, reproducibility and slow recovery of performance. The use of a strong ion pairing agent to increase retention renders the separation incompatible with mass spectrometric detection and complicates preparative separations. This paper describes the successful applications of a novel type of silica-based, hyper-crosslinked, sulfonate-modified reversed stationary phase, denoted as − SO 3 -HC-C 8 -L, for the separation of highly hydrophilic cations and related compounds by a hydrophobically assisted cation-exchange mechanism. Compared to conventional reversed-phases, the − SO 3 -HC-C 8 -L phase showed significantly improved retention and separation selectivity. Concurrently, due to the presence of both cation-exchange and reversed-phase retention mechanisms and the high acid stability of hypercrosslinked phases, the separation can be optimized by changing the type or concentration of ionic additive or organic modifier, and by varying the column temperature. In addition, gradients generated by programming the concentration of either the ionic additive or the organic modifier can be applied to reduce the analysis time without compromising resolution. Furthermore, remarkably different chromatographic selectivities, especially toward cationic solutes, were observed upon comparison of the − SO 3 -HC-C 8 -L phase with conventional reversed-phases. We believe that the combination of these two types of stationary phases will be very useful in two-dimensional liquid chromatography.

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Section: 13supporting

confidence: 82%

supporting

confidence: 58%

Application of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases for separating highly hydrophilic basic compounds

Luo

Paek

et al. 2008

Journal of Chromatography A

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“…At the moment, no evidence of a significant improvement of the column efficiency with variation of the column temperature has been obtained except results of Rey and Pohl [29], who observed a 32 -41% increase in peak efficiencies with increase in the column temperature up to 508C for alkaline earth metal cations separated on an IonPac CS12A column having mixed phosphonic-carboxylic functional groups. It should be noted that the authors separated these cations under noncomplexing conditions in 18 mM methane sulfonic acid.…”

Section: The Main Factors Influencing Separation In Hpcic 221 Tempementioning

confidence: 87%

Recent developments in the high‐performance chelation ion chromatography of trace metals

Nesterenko¹,

Jones

2007

J of Separation Science

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Review Recent developments in the high-performance chelation ion chromatography of trace metalsThere have been a number of significant developments in the high-performance chelation ion chromatography (HPCIC) of trace metals in recent years. This review focuses on these developments, while giving important information on the fundamental parameters controlling the chelation sorption mechanism, including type of chelating group, stability constants, kinetics, and column temperature. The discussion pays particular attention to the types and properties of efficient chelating stationary phases which have been fabricated for certain groups of metals. The review also describes a number of major improvements in postcolumn reaction detection including the use of the latest reagents and noise reduction strategies to improve sensitivity and reduce LOD. In the final section, an indication of the applicability of HPCIC to a range of complex sample types is given with some key examples and chromatograms using the latest high-efficiency chelating phases.

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“…With the technique of IC, a variety of parameters could be detected in one run Marchetto et al, 1995;Rey and Pohl, 1996). In addition, IC has high reliability and sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Detection of Nitrite and Nitrate in Celeries and Carrots

Liu¹,

Niu²,

Kong³

et al. 2016

American Journal of Biochemistry and Biotechnology

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Abstract:In this study, the anions nitrite ion (NO 2 -) and nitrate ion (NO 3 -) in celeries and carrots were detected with the technique of ion chromatography. A Dionex ICS-2000 ion chromatograph was used to detect the content of NO 2 -and NO 3 -in celeries and carrots. NO 2 -and NO 3 -were separated on a DIONEX Ionpac AS19 A-4 mm ion-exchange column and an Iopac AG AS19 A-4 mm guard column. The eluant was suppressed with an anion electrical self-regenerating suppressor (ASRS 300) and the content of NO 2 -and NO 3 -was detected with a conductivity detector. The detection limits were obtained for anions NO 2 -and NO 3 -. The present results showed that the ion chromatography was a suitable technique for the simultaneous determination of NO 2 -and NO 3 -in vegetables.

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Novel cation-exchange stationary phase for the separation of amines and of six common inorganic cations

Cited by 57 publications

References 5 publications

Application of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases for separating highly hydrophilic basic compounds

Application of silica-based hyper-crosslinked sulfonate-modified reversed stationary phases for separating highly hydrophilic basic compounds

Recent developments in the high‐performance chelation ion chromatography of trace metals

Simultaneous Detection of Nitrite and Nitrate in Celeries and Carrots

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