Novel Cerebrosides Isolated from the Fermentation Mycelia of <i>Tuber indicum</i>

Li, Yuanyuan; Liu, Ping; Tang, Yang; Li, Hongmei; Tang, Yaling; Liang, Xin‐hua; Tang, Ya‐Jie

doi:10.1002/hlca.201200235

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Reduction of the aldehyde in A-3 into the primary alcohol give A-4, and formation of 1, 2 by nucleophilic attack of the primary alcohol on either site of the carbons in one of the two epoxide groups and hydration in the rest epoxide group, and the similar biosynthetic conversion was also reported in aspilactonol B, C [5]. Other known compounds were isolated and determined as chrysogeside D (3) [7], aspinonene (4) [6], aspinotriols A (5) and B (6) [6], 22E,24R-ergosta-7,22-diene-3,5,6-triol (7) [8], mellein (8) [9], 4-hydroxymellein ( 9) [10].…”

Section: Resultsmentioning

confidence: 58%

“…The mixture of compound 1 and 2, and other isolated compounds (3)(4)(5)(6)(7)(8)(9) were evaluated for antimicrobial activity against the pathogenic bacteria and fungi, Escherichia coli, Bacillus subtilis, Candida albicans, Fusarium oxysporum, Fusarium solani. Compound 8 indicated the broad spectrum antibiotic activity against all five pathogens with MICs at 128-256 µg/mL.…”

Section: Resultsmentioning

confidence: 99%

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A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

Wang¹,

Yang²,

Miao³

et al. 2018

Rec.Nat.Prod.

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Two new aspinotriol derivatives (1-2) determined as melleusin A (1), B (2) and other seven known compounds were isolated from a soil-borne fungus Aspergillus melleus. The configurations of 1, and 2 were determined by their analogues, aspilactonol B, C isolated previous in Aspergillus. Mellein (8) showed broad antibiotic activity against the test pathogens. Aspinonene, aspinotriols A and B can be used as the marker molecule in chemotaxonomy of Aspergillus.

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Section: Resultsmentioning

confidence: 58%

Section: Resultsmentioning

confidence: 99%

A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

Wang¹,

Yang²,

Miao³

et al. 2018

Rec.Nat.Prod.

View full text Add to dashboard Cite

show abstract

“…By the same manner, the geometry of the double bond at C-3 was presumed to be E due to the large vicinal coupling constant of the olefinic protons (J H3 -4 = 15.3 Hz) [36]. The geometry of the double bond at C-8 was presumed to be E due to the 13 C-NMR signal of the methyl group attached to C-8 at δ C 16.1, while that of a (Z)-C=C bond appeared at δ C 22.7 [38]. The 2-amino-1,3-dioxigenated-4-ene moiety was confirmed by COSY correlations for H-1 through H-8 ( Figure 1, Figure S5).…”

Section: Structural Elucidation Of Compounds 1-4mentioning

confidence: 99%

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

et al. 2020

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Chemical investigation of the ethyl acetate extract of Penicillium chrysogenum strain S003, a fungus isolated from Red Sea deep sediment, led to the isolation of a cerebroside molecular species LAMA (1) along with three other known compounds, ergosterol (2), epidioxyergosterol (3), and kojic acid (4). The structures of the isolated compounds were elucidated by interpretation of spectral data, including detailed 1D and 2D NMR (One and two dimensional Nuclear Magnetic Resonance) and mass spectrometry. The cytotoxic activities of isolated compounds 1–4 against five human carcinoma cells were evaluated using sulforhodamine B (SRB) assay. Compounds 2 and 3 displayed promising cytotoxic profiles against lung cancer (A-549), prostate (DU-145), breast adenocarcinoma (MCF-7), and hepatocellular (HepG2) cell lines, with IC50 values of 21.26, 19.3; 1.50, 6.10; 16.95, 13.6; and 2.89, 3.07 µM, respectively, while they were inactive against HeLa cells. Compounds 1 and 4 showed weak cytotoxic profiles against all cell lines under investigation.

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Cell Factories of Higher Fungi for Useful Metabolite Production

Qin

Xiao

et al. 2015

Bioreactor Engineering Research and Industrial Applications I

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Higher fungi or called as macro-fungi, consisting of the divisions ascomycetes, basidiomycetes, and imperfect fungi, are receiving great interest around the world, because studies of higher fungi help us not only to find new edible and officinal resources but also to understand their complicated biology. In recent decades, a large number of useful substances from higher fungi have been isolated, identified, and characterized, which have important biological functions, such as reducing blood pressure, enhancing immunity, and possessing anti-cancer and anti-HIV and other pharmacological activities. This chapter will review the genetic manipulation tools for higher fungi, omics analysis of higher-fungus cell factories, and production of useful metabolites by higher fungi, including those of terpenoids, heterocyclics, polysaccharides, and polyketides. Trends in future development of cell factories of higher fungi for useful metabolite production will also be analyzed. Graphical Abstract Strategies for improving cell factories of higher fungi for useful metabolite production.

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Novel Cerebrosides Isolated from the Fermentation Mycelia of Tuber indicum

Cited by 4 publications

References 16 publications

A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum

Cell Factories of Higher Fungi for Useful Metabolite Production

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