Novel chiral ferrocenylpyrazolo[1,5-a][1,4]diazepin-4-one derivatives – Synthesis, characterization and inhibition against lung cancer cells

Experimental and Theoretical Studies of the Factors Affecting the Cycloplatination of the Chiral Ferrocenylaldimine (SC)-[(η5-C5H5)Fe{(η5-C5H4)–C(H)=N–CH(Me)(C6H5)}]

“…This agrees with results obtained for compounds D and E ( Figure 2) and suggest that the planar quirality of the metallated ring is not as important as the type of metallated carbon. Some authors have also found that for substituted ferrocene derivatives with stereogenic carbon atoms and their transition metal complexes, the absolute configuration does not affect significantly their cytotoxic activity [64][65][66].…”

Microwave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives

“…This Cellular assays on selected human lung cancer cell lines showed that some of these newly synthesized compounds exerted anti-proliferative activity against A549, H322 and H1299. In addition, it appeared that the anti-cancer activity wasn't dependant of the chirality of the compounds [43,44].…”

“…A very useful synthesis of novel 2-ferrocenyl-7-hydroxy-5-phenethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepin-4-one derivatives 99 and 101 has been described by Shen et al [43] (Scheme 17). These compounds have been synthesized through the reaction of (R) or (S)-3-ferrocenyl-1-(oxiran-2-ylmethyl)-1H-pyrazole-5-carboxylates 98, 100, and substituted phenylethylamines.…”

“…A very useful synthesis of novel 2-ferrocenyl-7-hydroxy-5-phenethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepin-4-one derivatives 99 and 101 has been described by Shen et al [43] (Scheme 17).…”

A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin

“…[27][28] Meanwhile a number of recent research projects have focused on biologically-oriented ferrocene compounds substituted by heterocyclic skeletons, including for example nucleobases, sugars or flavonoids. [29][30][31][32][33][34][35][36][37][38][39][40][41] In this context, the novel series shown below seems particularly appealing whereby a heterocyclic group such as succinimidyl or phthalimidyl, as in 3 or 4, respectively, has been incorporated into the molecule. We note that in bioorganometallic chemistry, examples of compounds that have significantly low IC 50 values on EOC cells resistant to cisplatin are practically nonexistent, except for rare complexes of ruthenium or osmium, having structures different from the ferrociphenols, and which appear promising.…”