Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery

Nagamoto, Takahiro; Hattori, Yoshiyuki; Takayama, Kozo; Maitani, Yoshie

doi:10.1023/b:pham.0000022414.17183.58

Cited by 127 publications

(59 citation statements)

References 12 publications

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“…Nanoparticulate drug delivery systems have the capability to enhance the bioavailability of drugs upon intranasal administration compared to drug solutions [38][39][40][41][42][43]. These formulations were reported to increase the residence time in the nasal cavity and prevent the effect of enzymatic degradation on these drugs [41].…”

Section: Nanoparticular Delivery Systemmentioning

confidence: 99%

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

Dudhipala¹,

Narala²,

Bomma³

2016

J Bioequiv Availab

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Section: Nanoparticular Delivery Systemmentioning

confidence: 99%

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

Dudhipala¹,

Narala²,

Bomma³

2016

J Bioequiv Availab

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“…In fact, chitosan stimulates the synthesis of cytokines and activates immune cells such as macrophages, natural killer cells (NK), APC cells and T lymphocytes (Foged et al, 2005;Nagamoto et al, 2004;Nishimura et al, 1984;Peluso et al, 1994;Porporatto et al, 2005;Koppolu & Zaharoff 2013).…”

Section: Chitosanmentioning

confidence: 99%

Nanoparticles and microparticles of polymers and polysaccharides to administer fish vaccines

2013

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Aquaculture has become an important economic sector worldwide, but is faced with an ongoing threat from infectious diseases. Vaccination plays a critical role in protecting commercially raised fi sh from bacterial, viral and parasitic diseases. However, the production of eff ective vaccines is limited by the scarcity of knowledge about the immune system of fi sh. Improving vaccines implies using antigens, adjuvants and employing methods of administration that are more eff ective and less harmful to the fi sh. In this context, in recent year there have studies of methods of encapsulating antigens in matrices of diff erent types to apply in fi sh vaccines. This work reviews the new methods to improve fi sh vaccines by encapsulating them in polymers and polysaccharides.

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“…Then the components were mixed by gently stirring with magnetic stirrer and water was added drop-wise. The mixture was stored at room temperature until further use [3].…”

Section: Preparation Of Microemulsionmentioning

confidence: 99%

“…Then the prepared microemulsion was added to equal amount of the chitosan mixture. The concentration of chitosan in the microemulsion was 4mg/ ml [3]. Characterization Surface morphology and shape Microstructure of the formulation was characterized by TEM.…”

Section: Preparation Of Chitosan Coated Microemulsionmentioning

confidence: 99%

“…This emulsion offers a significant advantage of increasing solubility of active agents for delivering active agent through skin. Advantages of this system are high biodegradability and low toxicity, reduction in the clearance rate, increase in contact time with skin, ease of manufacturing etc [3]. In case of psoriasis, methoxsalen has been administered topically or systemically.…”

Section: Introductionmentioning

confidence: 99%

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Methoxsalen loaded chitosan coated microemulsion for effective treatment of psoriasis.

Behera¹,

Keservani²,

Yadav³

et al. 2010

Int j Drug delivery

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Methoxsalen has been used for the treatment of psoriasis. In order to develop alternative formulations for the topical administration of methoxsalen, chitosan coated microemulsion were evaluated as delivery vehicle. Microemulsions were prepared using water, soyabean oil. Egg phosphatidylcholine, ethanol and coated with chitosan. They were characterized for shape and surface morphology, droplet size and size distribution, zeta potential, pH and viscosity. The ability of the system to deliver into the skin was evaluated using dialysis membrane and human cadaver skin. The in vitro permeation data showed that the novel system cumulative amount released was 18.75 % lesser than the microemulsion. These studies clearly show that methoxsalen loaded chitosan-coated microemulsion provides control release of methoxsalen with retention on the skin. Therefore may be appropriate vehicle for topical delivery of methoxsalen.

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Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery

Cited by 127 publications

References 12 publications

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

Nanoparticles and microparticles of polymers and polysaccharides to administer fish vaccines

Methoxsalen loaded chitosan coated microemulsion for effective treatment of psoriasis.

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