Novel combined fibrosis-based index predicts the long-term outcomes of hepatocellular carcinoma after hepatic resection

Yanagaki, Mitsuru; Shirai, Yoshihiro; Hamura, Ryoga; Taniai, Tomohiko; Tanji, Yoshiaki; Haruki, Koichiro; Furukawa, Kiyonori; Onda, Shinji; Shiba, Hiroaki; Ikegami, Toru

doi:10.1007/s10147-021-02111-7

Cited by 6 publications

(2 citation statements)

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“…The diagnosis of cholangiocarcinoma is accomplished by the combination of clinical/biochemical features and imaging findings with nonspecific tumor markers for suggestive complementary [ 49 ]. There is a lack of prognostic and predictive tumor markers for ICC, particularly compared with the clinical significance indicated by elevated AFP level and prognostic efficiency of PIVKA-II in HCC [ 50 , 51 ]. The combination of CEA, CA125, and CA19-9 had been reported to have diagnostic effects [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Anatomical Resection Improved the Outcome of Intrahepatic Cholangiocarcinoma: A Propensity Score Matching Analysis of a Retrospective Cohort

Wang

Ciren

Danzeng

et al. 2022

Journal of Oncology

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Background. Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy after hepatocellular carcinoma (HCC), with a dismal prognosis and high heterogeneity. The oncological advantages of anatomical resection (AR) and nonanatomical resection (NAR) in HCC have been studied, but surgical strategies for ICC remain controversial with insufficient investigations. Materials and Methods. From Jan 2013 to Dec 2016, 3880 consecutive patients were retrospectively reviewed from a single center. Patients with ICC undergoing AR or NAR have been enrolled according to inclusion and exclusion criteria. Propensity score matching (PSM) analysis was performed between two groups with a 1 : 1 ratio. The primary endpoint was overall survival (OS), and the secondary endpoints included disease-free survival (DFS), intraoperative patterns, postoperative morbidity, mortality, complications and recurrence. A prognostic nomogram was developed by a multivariate Cox proportion hazard model. Results. After PSM, 99 paired cases were selected from 276 patients enrolled in this study. Patients in the AR group achieved better 1-, 3-, and 5-year OS (70%, 46%, and 34%, respectively) and DFS (61%, 21%, and 10%, respectively) than patients in the NAR group with statistical significance after PSM analysis. The postoperative complications and recurrence patterns were comparable between the two groups. Multivariate analysis identified NAR, tumor size >5 cm, multiple tumors, and poor differentiation as independent risk factors for OS ( p < 0.05 ). Selected patients can benefit most from AR, according to subgroup analysis. A prognostic nomogram based on six independent risk factors for OS and factors with clinical significance was constructed to predict OS in ICC patients. Conclusion. AR improved the long-term survival of ICC with comparable postoperative complications and similar recurrence patterns. AR is suggested in ICC patients with sufficient remnant liver volume. In addition to surgery strategy, malignant characteristics of tumors are risk factors for ICC prognosis.

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Section: Discussionmentioning

confidence: 99%

Anatomical Resection Improved the Outcome of Intrahepatic Cholangiocarcinoma: A Propensity Score Matching Analysis of a Retrospective Cohort

Wang

Ciren

Danzeng

et al. 2022

Journal of Oncology

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“…A higher FIB‐4 index has been reported to be a prognostic factor for several cancer types. For example, a higher FIB‐4 index is associated with increased mortality among patients with hepatocellular carcinoma 12 , 13 , 14 and among those who undergo hepatectomy for colorectal cancer liver metastases. 15 A higher FIB‐4 index is also associated with anastomotic leakage among patients who undergo surgery for esophageal cancer 16 and increased mortality among those who undergo surgery for stomach cancer.…”

Section: Introductionmentioning

confidence: 99%

Liver injury indicators and subsequent cancer development among non‐fatty liver population

et al. 2023

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Protein induced by vitamin K absence or antagonist II: Experience to date and future directions

Dong,

Qiu,

Gao

et al. 2023

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Novel combined fibrosis-based index predicts the long-term outcomes of hepatocellular carcinoma after hepatic resection

Cited by 6 publications

References 36 publications

Anatomical Resection Improved the Outcome of Intrahepatic Cholangiocarcinoma: A Propensity Score Matching Analysis of a Retrospective Cohort

Anatomical Resection Improved the Outcome of Intrahepatic Cholangiocarcinoma: A Propensity Score Matching Analysis of a Retrospective Cohort

Liver injury indicators and subsequent cancer development among non‐fatty liver population

Protein induced by vitamin K absence or antagonist II: Experience to date and future directions

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