Novel concept of GRIN optical systems for high resolution microendoscopy: Part 1. Physical aspects

Messerschmidt, Bernhard; Kraeplin, Anke; Schenkl, Selma; Riemann, Iris; Stärk, Martin; Ehlers, Alexander; Tchernook, Andrei; Harzic, Ronan Le; Koenig, Karsten

doi:10.1117/12.698831

Cited by 9 publications

(6 citation statements)

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“…However, we developed a technology based on a semi-sphere in front of the GRIN optics which increases the possible numerical aperture to values up to 0.65 [15].…”

Section: Clinical Two-photon Microendoscopymentioning

confidence: 99%

Clinical multiphoton tomography

König

2008

Journal of Biophotonics

277

256

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Clinical multiphoton tomography and two-photon microendoscopy provide clinicians and researchers with high-resolution in vivo optical biopsies based on two-photon autofluorescence, second harmonic generation, and fluorescence lifetime imaging. This review reflects state of the art technology and reports on applications in the fields of early stage melanoma detection, skin aging, nanoparticle imaging, tissue engineering, and in situ screening of pharmaceutical and cosmetical products. So far, more than 500 patients and volunteers in Europe, Asia, and Australia have been investigated with these novel molecular imaging tools.

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“…However, we developed a technology based on a semi-sphere in front of the GRIN optics which increases the possible numerical aperture to values up to 0.65 [15].…”

Section: Clinical Two-photon Microendoscopymentioning

confidence: 99%

Clinical multiphoton tomography

König

2008

Journal of Biophotonics

277

256

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“…Laser pulses are guided through the PCF to the ultra-compact fiberscope headpiece. The laser beam coming out of the PCF fiber is coupled in a custom designed assembly of GRIN-lenses with 1-mm high NIR reflexion 90 ° prism (P) and 1.3 mm dichroic beam-splitting cube (D) (GRINTECH GmbH, Germany) [18][19][20] . The dichroic coating was designed to reflect ~93% of the near-IR excitation light while transmitting ~95% of the fluorescence emission light in the visible regime (~530 nm).…”

Section: Methodsmentioning

confidence: 99%

New developments in two photon endoscopy

et al. 2009

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We designed and constructed a two-fiber-optic two-photon endoscope with compact two axes piezo scanner system and a miniature high 0.65 NA Grin lens objective. The high NA GRIN lens objective coupled to the fibers with a beam splitter cube represent a rigid miniaturized optical system block which is scanned as a whole by a piezo scanner allowing always an on-axes beam irradiation of the optical system. We have demonstrated the ability of our system to perform good images in the micrometer field. Fluorescence detection was able at different wavelengths between 790 and 840 nm which could allow SHG detection. The endoscope is high flexible and controllable in terms of time acquisition, resolution and magnification. Fluorescence images were acquired over a maximal 420 µm x 420 µm field-of-view

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“…Therefore, theses systems were able to resolve fluorescent structures in the micrometer regime but were outperformed by standard, higher-NA two-photon microscopes. Newly developed GRIN-assemblies can have NAs of up to 0.85 and therefore exhibit even higher optical resolution and better light collection efficiencies [106, 119]. However, application of these high-NA systems in miniaturized microscopes is still pending.…”

Section: Sfe Applicationsmentioning

confidence: 99%

Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging

Lee

Engelbrecht

Soper

et al. 2010

Journal of Biophotonics

257

227

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In modern endoscopy, wide field of view and full color are considered necessary for navigating inside the body, inspecting tissue for disease and guiding interventions such as biopsy or surgery. Current flexible endoscope technologies suffer from reduced resolution when device diameter shrinks. Endoscopic procedures today using coherent fiber bundle technology, on the scale of 1 mm, are performed with such poor image quality that the clinician’s vision meets the criteria for legal blindness. Here, we review a new and versatile scanning fiber imaging technology and describe its implementation for ultrathin and flexible endoscopy. This scanning fiber endoscope (SFE) or catheterscope enables high quality, laser-based, video imaging for ultrathin clinical applications while also providing new options for in vivo biological research of subsurface tissue and high resolution fluorescence imaging.

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Novel concept of GRIN optical systems for high resolution microendoscopy: Part 1. Physical aspects

Cited by 9 publications

References 0 publications

Clinical multiphoton tomography

Clinical multiphoton tomography

New developments in two photon endoscopy

Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide‐field, full‐color imaging

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