Novel Copper Bearing Schiff Bases with Photodynamic Anti-Inflammatory and Anti-Microbial Activities

Ayaz, Furkan; Gönül, İlyas; Demirbag, Burcu; Ocakoğlu, Kasım

doi:10.1007/s12010-019-03223-7

Cited by 10 publications

(3 citation statements)

References 41 publications

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“…The MIC of Cu 2 L 35 /P 60% was determined as low as 0.64 μg/mL. Control experiments reveal a 617-fold increase in antimicrobial activity when comparing a low molecular weight binuclear complex Cu 2 L 35 to its microgel analogue Cu 2 L 35 /P 60% .…”

Section: N-donor Ligandsmentioning

confidence: 97%

“…In this work [34], it was established once again that metal chelates have higher activity than free ligands. 28 and HL 29 ) derived from 2-hydroxy-3-methoxy benzaldehyde and 3-ethoxy-2-hydroxybenzaldeyhde with N,N′-dimethylethane-1,2diamine have been prepared [35]. It is interesting to note that small structural changes in the ligand (replacement of a methyl group by an ethyl group in the aromatic fragment) lead to significant changes in the stoichiometry of the compounds formed: compound 28 is a binuclear complex with acetate bridging ligands, and 29 is a coordination polymer.…”

Section: N-donor Ligandsmentioning

confidence: 99%

“…The spherical, water-dispersed microgels (P) are synthesized from miniemulsions that are obtained by ultra-sheering of monomer mixtures in aqueous solutions. A pre-polymerization mixture typically consists of ethylene glycol dimethacrylate (EGDMA) as a cross-linking agent, butyl acrylate (BA) as a monomer, and L 35 as a pentadentate backbone ligand. The immobilized ligand is usually transformed in situ into a binuclear metal complex by addition of Cu(OAc) 2 prior to polymerization.…”

Section: N-donor Ligandsmentioning

confidence: 99%

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Recent Studies on the Antimicrobial Activity of Copper Complexes

Zalevskaya

Gur’eva

2021

Russ J Coord Chem

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The analysis of publications in 2020, devoted to the synthesis of copper(II) complexes and the study of their antimicrobial properties, indicates that this area of medicinal chemistry is promising. Organic compounds of various classes were studied as starting ligands. First of all, these are N-donor imines, amines, heterocyclic compounds, as well as N,O-donor ligands and sulfur-containing ligands. In most works, the fact of a higher biological activity of the metal complex in comparison with the corresponding ligand was established. Evaluating the influence of the nature of the metal on the antimicrobial activity of the metal complex, the authors most often come to the conclusion that it is copper(II) complexes that are the most effective inhibitors of the growth of pathogenic bacteria. The scale of the studies presented indicates a high interest in this group of metal complexes, and the results indicate good prospects for using copper complexes as antimicrobial drugs.

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Section: N-donor Ligandsmentioning

confidence: 97%