Novel copper(<scp>ii</scp>) complexes with fenamates and isonicotinamide: structure and properties, and interactions with DNA and serum albumin

Jozefíková, Flóra; Perontsis, Spyros; Šimunková, Miriama; Barbieriková, Zuzana; Švorc, Ľubomír; Valko, Marián; Psomas, George; Moncóľ, Ján

doi:10.1039/d0nj02007a

Cited by 18 publications

(6 citation statements)

References 98 publications

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“…42 Similar binding constants to those of BSA were previously reported for copper(II) complexes with non-steroidal anti-inflammatory agents, such as tolfenamic, meclofenamic, mefenamic, clo- nixic and niflumic acids, and different nitrogen-donor ligands. [44][45][46] The number of binding sites per BSA molecule is similar for all complexes, which is in accordance with their tendency to bind to one site in the protein (Table 2). Synchronous fluorescence measurements.…”

Section: Protein Binding Studysupporting

confidence: 72%

“…However, the values of the binding constants (K A , Table S1 †) of the investigated complexes are much lower than that of EthBr itself (K A = 2 × 10 6 M −1 ), 43 and those of previously reported copper(II) complexes with fenamates and isonicotinamide, for which an intercalation mode of interaction with ct-DNA was proposed. 44 Considering this, a more reasonable explanation for reduction in the emission intensity of the EthBr-DNA system in the presence of 1-5 could be the binding of the complexes to the EthBr-DNA conjugate, leading to the formation of a new nonfluorescent EthBr-DNA-complex system.…”

Section: Complexmentioning

confidence: 99%

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Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

et al. 2021

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Section: Protein Binding Studysupporting

confidence: 72%

Section: Complexmentioning

confidence: 99%

Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

et al. 2021

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“…As mentioned before, our CQDs were fabricated via neocuproine and citric acid. As is apparent, the neocuproine bearing pyridinic rings with high potential for complexation with cupric ions 94 , 95 . Hence, the pyridine-like rings of this ligand might be possibly located at the surface of as-prepared CQDs (Fig.…”

Section: Resultsmentioning

confidence: 99%

Selective and sensitive CQD-based sensing platform for Cu2+ detection in Wilson’s disease

Zarei,

Rezaei,

Shahlaei

et al. 2024

Sci Rep

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Excessive Cu2+ intake can cause neurological disorders (e.g. Wilson’s disease) and adversely affect the gastrointestinal, liver, and kidney organs. The presence of Cu2+ is strongly linked to the emergence and progression of Wilson's disease (WD), and accurately measuring the amount of copper is a crucial step in diagnosing WD at an early stage in a clinical setting. In this work, CQDs were fabricated through a facile technique as a novel fluorescence-based sensing platform for detecting Cu(II) in aqueous solutions, and in the serum samples of healthy and affected individuals by WD. The CQDs interact with Cu(II) ions to produce Turn-on and Turn-off states at nano-molar and micro-molar levels, respectively, with LODs of 0.001 µM and 1 µM. In fact, the Cu2+ ions can act like a bridge between two CQDs by which the charge and electron transfer between the CQDs may increase, possibly can have significant effects on the spectroscopic features of the CQDs. To the best of our knowledge, this is the first reported research that can detect Cu(II) at low levels using two different complexation states, with promising results in testing serum. The potential of the sensor to detect Cu(II) was tested on serum samples from healthy and affected individuals by WD, and compared to results obtained by ICP-OES. Astonishingly, the results showed an excellent correlation between the measured Cu(II) levels using the proposed technique and ICP-OES, indicating the high potential of the fluorimetric CQD-based probe for Cu(II) detection. The accuracy, sensitivity, selectivity, high precision, accuracy, and applicability of the probe toward Cu(II) ions make it a potential diagnostic tool for Wilson's disease in a clinical setting.

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“…The excitation wavelength was set to 515 nm, and spectra were recorded in the range of 550 nm to 800 nm. The Stern–Volmer equation (Equation (1)) was used to evaluate the measured data, similarly to the BSA interaction study [ 49 ].…”

Section: Methodsmentioning

confidence: 99%

Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

et al. 2023

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Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article. Complexes contain 2,2′-bipyridine molecules and salicylates as ligands, differing in position and type of halogen substituent. The structure of the complexes was determined via X-ray structural analysis and NMR spectroscopy. All complexes were characterized by spectral methods—FTIR, UV–Vis, ESI-MS. Complexes show sufficient stability in solutions. Therefore, their biological properties were studied. Binding ability to BSA, interaction with DNA, as well as in vitro antiproliferative effects against MCF-7 and U-118MG cell lines were investigated. Several complexes showed anticancer effects against these cell lines.

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Novel copper(ii) complexes with fenamates and isonicotinamide: structure and properties, and interactions with DNA and serum albumin

Abstract: Reactions of non-steroidal anti-inflammatory drugs tolfenamic, meclofenamic, mefenamic, clonixic and niflumic acids with isonicotinamide and copper(ii) acetate resulted in the formation of five novel mixed-ligand Cu(ii) coordination compounds.

Cited by 18 publications

References 98 publications

Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

Tailoring copper(ii) complexes with pyridine-4,5-dicarboxylate esters for anti-Candida activity

Selective and sensitive CQD-based sensing platform for Cu2+ detection in Wilson’s disease

Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity

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