Novel Cyclomatrix-Type Polyphosphazene Microspheres Crosslinked With Octachlorocyclotetraphosphazene: Preparation and Characterization

Abstract

In this article, highly cross-linked inorganic and organic hybrid polyphosphazene microspheres including amino groups on the surface have been successfully obtained via self-assembly polycondensation approach using 4,4ʹ-diaminodiphenylmethane and octachlorocyclotetraphosphazene which is a new crosslinker. Experiments were performed without adding a surfactant or stabilizer, using only an ultrasonic bath. Otherwise, effect of different molar ratios of the reactants, reaction time and ultrasonic power were investigated on preparing morphologically good spheres. The reactivity of octachlorocyclotetraphosphazene was investigated comparing with hexachlorocyclotriphosphazene which is the most popular crosslinker cyclic phosphazene molecule. The size of acquired microspheres were approximately same, and 1.00μm. The novel microspheres were characterized by SEM, FTIR, ZETA, UV, Fluorescense, XRD and TGA methods.

Recent Progress on the Preparation of Cyclomatrix‐Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release

“…Furthermore, the other differentiating peaks appeared at 1293, 1228 and 963 cm À 1 were assigned to P=N and PÀ N absorption bands of OCCP. [50] The mechanism for the formation of microspheres is described as: Firstly, OCCP was reacted with OCDA to form oligomers. Then the oligomers aggregated to generate primary nucleus particles.…”

“…Reaction mechanism for the formation of OCDA-based microspheres. [50] Reprinted with the permission from reference copyright 2017, Journal of Science and Technology A-Applied Sciences and Engineering.…”

The Synthesis and Characterization of O-Dianisidine Derived Crosslinked Trimeric and Tetrameric Polyphosphazene Microspheres

“…Cyclomatrix polyphosphazenes are obtained by precipitation polymerization method. In these reactions, cyclic phosphazene compounds act as crosslinkers and polyfunctional alcohols/amines act as monomers [15][16][17]. As a result of the substitution of the cyclic phosphazenes used in this method with nucleophiles, it is possible to realize the formation of cross-linked nano/microspheres of the same size.…”

Intrinsically fluorescent and quercetin loaded highly crosslinked polyphosphazene nanospheres: synthesis, characterization and fluorescence properties

“…Apart from the materials mentioned above, the polyphosphazenes have special properties including highly crosslinked structure[ 27 ], dispersibility in water and organic media [ 28 ], biodegradability [ 29 ], and biocompatibility [ 30 ]. Therefore, highly crosslinked inorganic-organic polyphosphazene nano/micromaterials have been synthesized via polycondensation polymerization between hexachlorocyclotriphosphazene (HCCP) [ 31 – 33 ] or octachlorocyclotetraphosphazene (OCCP) [ 34 , 35 ] and monomers including two or more amino/hydroxyl/thyol groups [ 36 – 38 ], and their fluorescence applications have investigated such as fluorescent sensors to detection of some metal ions (Fe 3+ , Hg 2+ ) [ 39 , 40 ], nitroaromatic explosives [ 41 ], picric acid [ 42 ], dopamine [ 43 ], drug delivery [ 44 ], cell [ 45 , 46 ], and tumour imaging [ 47 ].…”