Novel cytotoxic ring-a seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis

Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera

“…Assignments of the 1 H and 13 C signals as shown in Table 1 were carried out on the basis of 2D-NMR spectral data (see Section 5 and Table 2) and by direct comparison of the chemical shifts with those of similar compounds reported in the literature. 14 The HMBC correlations of 18-Me signal to C-12, C-14 and C-17 signals confirmed the assignment of 18-Me signal, while the correlations of 30-Me signals to C-8, C-13 and C-15 supported the identification of 30-Me. The relative stereochemistry of 1 was determined on the basis of NOE difference data (see Fig.…”

Cytotoxic and Anti-angiogenic Properties of Minor 3,4-<i>seco</i>-Cycloartanes from <i>Gardenia sootepensis</i> Exudate

“…These include sootepin C (3), coronalonic acid (4), sootepin A (5), tubiferolide methyl ester (6), and coronalolide methyl ester (7). 10,13,14) Cytotoxic Activity As part of our ongoing efforts to investigate Thai natural products with potential for cancer therapy, compounds 1 and 2 were determined for their in vitro cytotoxicity toward five human tumor cell lines (BT474, CHAGO, KATO-3, SW620, and Hep-G2) and noncancerous CH liver cells. As shown in Table 2, sootependial (1) showed potent cytotoxicity against only Hep-G2 cell lines with an Anti-angiogenic Activity Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is also an important target for cancer therapy as the development of tumors is crucially angiogenesis-dependent.…”

Cycloartane triterpenes from the exudate of Gardenia thailandica

“…Plants belonging to the genus Gardenia have proved to produce a variety of cycloartane triterpenoids, some of which display interesting biological activities (Grougnet et al, 2006;Reutrakul et al, 2004;Silva et al, 1999;Tuchinda et al, 2002Tuchinda et al, , 2004. Additionally, extracts of various species exhibiting anti-implantation and abortifacient effects (Lu et al, 1981), and antiulcer (Takase et al, 1989), antibacterial (Laurens et al, 1985), diuretic, analgesic, hypertensive and larvicidal activities (Hussian et al, 1991;Manson, 1939) have been reported.…”