Novel Double Phase Transforming Organogel Based on β-Cyclodextrin in 1,2-Propylene Glycol

Abstract

This paper describes a novel double phase transforming organogel (gel-sol-gel') composed of nontoxic β-cyclodextrin, potassium carbonate, and 1,2-propylene glycol. The gel-sol-gel' transforming processes are followed by a reversible gel-sol transforming process and an irreversible sol-gel' transforming process based on heating. The gel-sol-gel' transformation is accompanied by microstructure changes from nanospheres to nanorods. K(2)CO(3) plays a key role in associating supramolecular architectures of β-cyclodextrin into a three-dimensional network. This work may bring further applications in the areas of smart materials, drug delivery systems, and biomaterials.

Characterization of supramolecular gels based on β-cyclodextrin and polyethyleneglycol and their potential use for topical drug delivery

“…The role of K 2 CO 3 was to facilitate the molecule-ion aggregates of β-CD as previously described [9]. This gelation may occur by the same mechanism as previously reported for the gelation of β-CD and a small molecule (propylene glycol) [34]. Longer channel type assembles were observed for Gel H , and these structures were probably formed by PPRs or a specific complex at a higher temperature (Fig.…”

Supramolecular cyclodextrin-based drug nanocarriers

“…Association of the threaded CDs from adjacent polypseudorotaxanes may lead to phase separation or to a three-dimensional network, depending on the polymer and its 35 concentration as well as on the temperature and ions content of the medium. 77,87,88 Interestingly the inter-polypseudorotaxane interactions are minimized when hydrophilic derivatives of the natural CDs are used; namely, hydroxypropyl-CDs can thread onto the polymers but do not stack. Thus, they form hydrosoluble 40 polypseudorotaxanes that do not significantly modify the turbidity/viscosity of the system.…”

Preparation and Characterization of Binary Organogels via Some Azobenzene Amino Derivatives and Different Fatty Acids: Self-Assembly and Nanostructures

“…Although gels are widely found in polymer systems, there has recently been an increasing interest in low-molecular-mass organic gelators (LMOGs) [5][6][7][8]. In recent years, physical gelation of organic solvents by LMOGs has become one of the hot areas in the soft matter research due to their scientific values and many potential applications in the biomedical field, including tissue engineering, controlled drug release, and medical implants [9][10][11][12]. The gels based on LMOGs are usually considered as supramolecular gels, in which the gelator molecules selfassemble into three-dimensional networks in which the solvent is trapped via various noncovalent interactions, such as hydrogen bonding, -stacking, van der Waals interaction, dipole-dipole interaction, coordination, solvophobic interaction, and host-guest interaction [13][14][15][16].…”