Novel Electrochemical Impedance Detection for Rocuronium by Using Polypyrrole and Cyclodextrin as the Sensing Material

Luk, Hsiang‐Ning; Jheng, Ren-Fang; Tsai, Te-Chin; Wu, Ren‐Jang

doi:10.1166/sl.2009.1241

Cited by 5 publications

(6 citation statements)

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“…These polypyrrole/β-cyclodextrin films (PPy/β-CD) can be formed by the simple electropolymerization of pyrrole in the presence of the β-CD and a supporting electrolyte to give PPy/β-CD adherent films. These polymeric materials have been employed in the detection of catecholamine compounds [108], various neurotransmitters [109][110][111], and methyl paraben [112], and utilized as an impedimetric sensor to detect rocuronium bromide, which is a muscle relaxant [113]. By employing anionic β-CDs, such as sulfonated or sulfated CDs (sβ-CD), the anionic β-CDs can be incorporated as dopants within the PPy matrix.…”

Section: Cyclodextrins Combined With Conducting Polymersmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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Supramolecular chemistry, although focused mainly on noncovalent intermolecular and intramolecular interactions, which are considerably weaker than covalent interactions, can be employed to fabricate sensors with a remarkable affinity for a target analyte. In this review the development of cyclodextrin-based electrochemical sensors is described and discussed. Following a short introduction to the general properties of cyclodextrins and their ability to form inclusion complexes, the cyclodextrin-based sensors are introduced. This includes the combination of cyclodextrins with reduced graphene oxide, carbon nanotubes, conducting polymers, enzymes and aptamers, and electropolymerized cyclodextrin films. The applications of these materials as chiral recognition agents and biosensors and in the electrochemical detection of environmental contaminants, biomolecules and amino acids, drugs and flavonoids are reviewed and compared. Based on the papers reviewed, it is clear that cyclodextrins are promising molecular recognition agents in the creation of electrochemical sensors, chiral sensors, and biosensors. Moreover, they have been combined with a host of materials to enhance the detection of the target analytes. Nevertheless, challenges remain, including the development of more robust methods for the integration of cyclodextrins into the sensing unit.

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Section: Cyclodextrins Combined With Conducting Polymersmentioning

confidence: 99%

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

et al. 2021

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“…The linear equation for the calibration plot in the standard sample is expressed as follows: Ip (μA)=0.021 (±0.006)+0.051 (±0.002) [Roc] (μg/mL) with a correlation coefficient of 0.998. The detection limit was determined to be 3.83±0.21 ng/mL (RSD <4.17 %, at 95 % confidence level, k=3, n=5), which is superior to the previously reported impedimetric sensor .…”

Section: Resultsmentioning

confidence: 99%

“…Despite of various analytical efforts, these methods need sophisticated instruments, require pre‐treatment for the separation, and time‐consuming derivatization step . To overcome these limitations, electrochemical methods have been used by combining with the HPLC . These trials enhanced the sensitivity and selectivity towards RNMB determination, but still have difficulty to apply for point‐of‐care device due to the usage of organic solvent and laborious steps with chromatography.…”

Section: Introductionmentioning

confidence: 99%

“…These trials enhanced the sensitivity and selectivity towards RNMB determination, but still have difficulty to apply for point‐of‐care device due to the usage of organic solvent and laborious steps with chromatography. Recently, impedimetric sensor for Roc detection was also reported , however, the detection limit (1 ppm) was not in the clinically relevant range. To date, there are no reports using an amperometric sensor without sample pre‐treatment.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Rocuronium in Whole Blood Using a Lipid‐bonded Conducting Polymer and Porous Carbon Composite Electrode

et al. 2018

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Rocuronium is a neuromuscular blocking agent used in anesthesia to facilitate tracheal intubation by muscle relaxation. A fast and sensitive amperometric sensor was developed for the detection of rocuronium in human whole blood samples. The sensor probe was fabricated using phosphatidylinositol lipid (PI) bonded 3′‐(2‐aminopyrimidyl)‐2,2′ : 5′,2′′‐terthiophene and porous carbon, which revealed the enhanced response to the rocuronium oxidation. The modified sensor layers were characterized by electrochemical and surface analysis experiments. The experimental parameters affecting the rocuronium analysis were studied in terms of PI concentration, amount of porous carbon, pH, temperature, and interferences. A dynamic range was observed between 0.025 to 10 μg/mL with the detection limit of 3.83±0.21 ng/mL. The reliability of proposed sensor was successfully demonstrated through the detection of rocuronium in clinical samples without pre‐treatment.

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“…The preliminary results showed that the obtained modified electrode is mechanically stable and features good permselectivity toward interferences such as ascorbic acid at a concentration of more than 500-fold for some neurotransmitters. Cyclodextrin-polypyrrole (CD-Ppy) was also fabricated on gold electrodes and used as sensors to detect concentrations of the muscle relaxant rocuronium bromide [117], where concentrations of 1 ppm could be detected.…”

Section: Applications Of Cyclodextrin Modified Electrode In Pharmaceumentioning

confidence: 99%

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Radi¹

2010

TOCBMJ

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Electrochemistry of cyclodextrins (CDs) and cyclodextrin inclusion complexes with different pharmaceutical compounds is reviewed. The article highlights some electrochemical investigations of the CD-drugs interactions in solution. Cyclodextrin modified electrodes and their applications as electrochemical sensors in pharmaceutical analysis based on the self-assembly of CD derivatives on metal electrodes and nanoparticles, and cyclodextrin-modified multiwalled carbon nanotubes are also discussed.

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Novel Electrochemical Impedance Detection for Rocuronium by Using Polypyrrole and Cyclodextrin as the Sensing Material

Cited by 5 publications

References 0 publications

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Cyclodextrins as Supramolecular Recognition Systems: Applications in the Fabrication of Electrochemical Sensors

Detection of Rocuronium in Whole Blood Using a Lipid‐bonded Conducting Polymer and Porous Carbon Composite Electrode

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

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