Novel Endocrine Disrupter Effects of Classic and Atypical Antipsychotic Agents and Divalproex: Induction of Adrenal Hyperandrogenism, Reversible with Metformin or Rosiglitazone

Bahtiyar, Gül; Weiss, Karolina; Sacerdote, Alan

doi:10.4158/ep.13.6.601

Cited by 27 publications

(15 citation statements)

References 19 publications

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“…In the case of psychiatric disorders, such as schizophrenia, therapeutic strategies that target the underlying metabolic dysfunction could provide an effective alternative to traditional antipsychotic medications 87 . This possibility is supported by the finding that the insulin-sensitizing agents metformin and rosiglitazone can correct the insulin resistance that seems to come hand in hand with antipsychotic treatment without inhibiting the antipsychotic drug efficacy in treating the disease 105 .…”

Section: Therapeutic Implicationssupporting

confidence: 56%

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Guest

Martins-de-Souza²,

Rahmoune

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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Over the last few decades, evidence has been emerging that the pathogenesis of psychiatric disorders such as schizophrenia can involve perturbations of the hypothalamic-pituitary-adrenal (HPA) axis. Variations in the manifestation of these effects could be related to the differences in clinical symptoms between affected individuals as well as to differences in treatment response. Such effects can also arise from the complex interaction between genes and environmental factors. Here, we review the effects of maternal stress on abnormalities in HPA axis regulation and the development of psychiatric disorders including schizophrenia. Studies in this area may prove critical for increasing our understanding of the multi-dimensional nature of schizophrenia. Further research in this area could ultimately lead to the development of improved diagnostics and novel therapeutic approaches for treating this debilitating psychiatric condition.Guest FL, et al. / Rev Psiq Clín. 2013;40(1):20-7 Keywords: Psychiatric disorders, schizophrenia, HPA axis dysfunction, diagnosis, biomarkers. ResumoNas últimas décadas, têm surgido evidências sugerindo que a patogênese de desordens psiquiátricas, tais como a esquizofrenia, pode envolver perturbações no eixo hipotalâmico-pituitário-adrenal (HPA). Variações na manifestação desses efeitos poderiam estar relacionadas a diferenças em sintomas clínicos entre os indivíduos afetados, assim como a diferenças na resposta ao tratamento. Tais efeitos podem também ser originados de complexas interações entre genes e fatores ambientais. Aqui, revisamos os efeitos do estresse maternal em anormalidades na regulação do eixo HPA e desenvolvimento de desordens psiquiátricas, incluindo a esquizofrenia. Estudos nessa área podem gerar o aumento do nosso entendimento da natureza multidimensional da esquizofrenia. Posterior pesquisa nesse campo poderia, em última instância, levar ao desenvolvimento de melhores diagnósticos e novas abordagens terapêuticas para essa debilitante condição psiquiátrica.Guest FL, et al. / Rev Psiq Clín. 2013;40(1):20-7 Palavras-chave: Desordens psiquiátricas, esquizofrenia, disfunção do eixo HPA, diagnóstico, biomarcadores.

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Section: Therapeutic Implicationssupporting

confidence: 56%

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Guest

Martins-de-Souza²,

Rahmoune

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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show abstract

“…This suggests that schizophrenia patients with high levels of insulin might benefit from coadministration of insulin-sensitizing agents. Along these lines, the drugs metformin and rosiglitazone have been administered in clinical studies to correct the antipsychotic-induced insulin resistance that is typically associated with this class of drugs (Bahtiyar et al, 2007).…”

Section: Personalized Medicine Approaches Using Circulating Biomarkersmentioning

confidence: 99%

Applications of blood-based protein biomarker strategies in the study of psychiatric disorders

Chan

Gottschalk

Haenisch

et al. 2014

Progress in Neurobiology

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“…The latter two groups of anti-retroviral drugs have also been associated with adrenal hyperplasia (Sacerdote, 2006). In our study we found that metformin corrected adrenal hyperandrogenism in 8/8 patients and rosiglitazone corrected adrenal hyperandrogenism in 2/2 patients on anti-psychotic drugs and/or valproate (Bahtiyar, 2007). (Figures 3 and 4).…”

Section: Metformin or Rosiglitazone In The Psychotropic/valproate-indmentioning

confidence: 78%

“…In Arit's study four of 203 patients with CAH had forms of NCAH other than 21-hydroxylase deficiency (Arit et al, 2010). We studied 26 consecutive, non-selected psychiatric patients taking classical anti-psychotic agents, atypical anti-psychotic agents, and/or valproate and we noted that all 26 had adrenal hyperandrogenemia; 2 had biochemical evidence of 21-hydroxylase deficiency, 8 of 3--ol-dehydrogenase deficiency, four of 11-hydroxylase deficiency, and two of aldosterone synthase deficiency (Bahtiyar et al, 2007). All of the above psychotropic agents cause insulin resistance and 10/10 patients who took an insulin sensitizer normalized biochemically.…”

Section: Other Forms Of Non-classical Cah Associated With Insulin Resmentioning

confidence: 99%

Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments

Bahtiyar¹,

Sacerdote²

2011

Amenorrhea

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Novel Endocrine Disrupter Effects of Classic and Atypical Antipsychotic Agents and Divalproex: Induction of Adrenal Hyperandrogenism, Reversible with Metformin or Rosiglitazone

Cited by 27 publications

References 19 publications

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Applications of blood-based protein biomarker strategies in the study of psychiatric disorders

Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments

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