Novel ferrocene-pyrazolo[1,5-a]pyrimidine hybrids: A facile environment-friendly regioselective synthesis, structure elucidation, and their antioxidant, antibacterial, and anti-biofilm activities

Das, Susma; Borkotoky, Shivangi; RYMBAI, MAXMILLANDO; Borah, Vedant Vikrom; Roy, Jayanti Datta; Kaping, Shunan; Helissey, Philippe; Vishwakarma, Jai N.

doi:10.1007/s12039-022-02064-y

Cited by 2 publications

(1 citation statement)

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“…To mitigate the toxicity induced by ROS stress, a chemical compound, ferrocene and its derivatives (synthetic ferrocene derivatives) have been proposed as a potential new class of antioxidants, showing free radical scavenging properties ( DAS et al., 2022 ). Ferrocenecarboxaldehyde, a derivative of ferrocene has been shown to possess antioxidant activities.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of hexaconazole induced oxidative stress by folic acid, malic acid and ferrocenecarboxaldehyde in an invertebrate model Bombyx mori

Ashraf¹,

Qamar²,

Maheshwari³

2022

Heliyon

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Section: Introductionmentioning

confidence: 99%

Attenuation of hexaconazole induced oxidative stress by folic acid, malic acid and ferrocenecarboxaldehyde in an invertebrate model Bombyx mori

Ashraf¹,

Qamar²,

Maheshwari³

2022

Heliyon

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Synthesis, Spectroscopic Characterization, Biocidal evaluation Molecular Docking & DFT Investigation of 16-18 membered Macrocyclic Complexes of Cobalt (II)

et al. 2022

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Macrocyclic ligands (MacL 1 -MacL 3 ) and Co(II) complexes were synthesized via template condensation of o-phenylenediamine with various aromatic dicarboxylic acids. The elemental analysis, FT-IR, mass spectrometry, 1 H NMR, 13 C NMR, UV-vis, SEM analysis, powder X-ray diffraction, thermogravimetric (TG) analysis, electrochemical studies, and DFT analysis were used to characterize these synthesized ligands and their cobalt (II) complexes. TGA analysis to determine the stability and decomposition kinetic parameters. In element analysis, the percentage of different elements present and also the stoichiometry of compounds were confirmed. The proposed framework for tetraaza macrocyclic cobalt (II) complexes was supported by spectral analysis, which also revealed distorted octahedral geometry surrounding the central metal atom. The molecular structure of cobalt (II) complexes was also optimized theoretically, and their electronic or thermodynamic parameters were obtained from density functional theory (DFT). The synthesized ligands and their cobalt (II) complexes were tested against bacteria: Escherichia coli, Bacillus subtitles. Candida albicans were tested for antifungal properties. It was found that ligands and complexes show good antimicrobial results. Finally, using the Auto Dock VinaPyRx programme, molecular docking studies were used to evaluate the biological significance of the synthesized ligands to identify the probable and efficient binding mechanisms between the various ligands and the active site of the receptor protein. Graphical abstract Antimicrobial, DFT, and Docking representation of Cobalt (II) macrocyclic complexes Supplementary Information The online version contains supplementary material available at 10.1007/s12039-022-02109-2.

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Novel ferrocene-pyrazolo[1,5-a]pyrimidine hybrids: A facile environment-friendly regioselective synthesis, structure elucidation, and their antioxidant, antibacterial, and anti-biofilm activities

Cited by 2 publications

References 55 publications

Attenuation of hexaconazole induced oxidative stress by folic acid, malic acid and ferrocenecarboxaldehyde in an invertebrate model Bombyx mori

Attenuation of hexaconazole induced oxidative stress by folic acid, malic acid and ferrocenecarboxaldehyde in an invertebrate model Bombyx mori

Synthesis, Spectroscopic Characterization, Biocidal evaluation Molecular Docking & DFT Investigation of 16-18 membered Macrocyclic Complexes of Cobalt (II)

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