Novel flow-through bulk optode for spectrophotometric determination of lithium in pharmaceuticals and saliva

Albero, M.I.; Ortuño, J; García, M.S.; Cuartero, María; Alcaraz, Marcela

doi:10.1016/j.snb.2009.11.053

Cited by 22 publications

(25 citation statements)

References 28 publications

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“…This value of LD can be compared with literature values in detection systems using optode 29 ) and laser-based semiconductor (LD of 3 x 10 -6 mol L -1 ). 32 The coefficient of selectivity was determined by the "matched potential" method.…”

Section: Resultsmentioning

confidence: 82%

Poly(o-methoxyaniline) modified electrode for detection of lithium ions

Lindino¹,

Casagrande²,

Peiter³

et al. 2012

Quím. Nova

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Recebido em 16/2/11; aceito em 12/9/11; publicado na web em 8/11/11 This paper reports the use of an electrode modified with poly(o-methoxyaniline) for detecting lithium ions. These ions are present in drugs used for treating bipolar disorder and that requires periodical monitoring of the concentration of lithium in blood serum. Poly(omethoxyaniline) was obtained electrochemically by cyclic voltammetry on the surface of a gold electrode. The results showed that the electrode modified with a conducting polymer responded to lithium ions in the concentration range of 1 x 10 -5 to 1 x 10 -4 mol L -1 . The results also confirmed that the performance of the modified electrode was comparable to that of the standard method (atomic emission spectrophotometry).

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Section: Resultsmentioning

confidence: 82%

Poly(o-methoxyaniline) modified electrode for detection of lithium ions

Lindino¹,

Casagrande²,

Peiter³

et al. 2012

Quím. Nova

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“…The chromoionophore was able to detect Li + in spiked blood serum up to 10 −5 mol dm −3 and in seawater to 2 × 10 −5 mol dm −3 , but not in hot spring water where it was present below 10 −6 mol dm −3 . More recently, Albero et al incorporated ionophore 9 together with chromophore 9-[4-diethylamino-2-(octadecanoyloxy)styryl]acridine and KT p ClPB in a PVC membrane to measure Li + in pharmaceuticals and saliva, over a 1 × 10 −4 to 1 × 10 −2 mol dm −3 concentration range [ 36 ]. Although sensitivity and linear response characteristics were good, selectivity was an issue with Li + :Na + selectivity of 104:1, Li + :Ca 2+ selectivity of 24:1 and Li + :Ba 2+ selectivity of 10:1.…”

Section: Sensorsmentioning

confidence: 99%

Lithium Ion Sensors

Kamenica

Kothur

Willows

et al. 2017

Sensors

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The detection and monitoring of lithium in environmental and clinical settings is becoming increasingly important. In this review, sensors incorporating conductive polymers and lithium bronzes are discussed, together with electrochemical and spectroscopic approaches. Ionophore-based methods have been employed extensively, with varying degrees of selectivity and sensitivity, and these are discussed in depth.

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“…Currently, there are various analytical techniques for lithium analysis including flame-AES [10,11], flame-AAS [12], ICP-AES [3,13], ICP-MS [14,15], spectrofluometry [16,17], flow through optode [18] and potentiometry with ion selective electrodes [19]. ICP spectroscopy is widely used for elemental analysis.…”

Section: Introductionmentioning

confidence: 99%

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

Dai¹,

Wigman²,

Zhang³

2015

Journal of Chromatography A

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A sensitive analytical method using mixed mode HPLC separation coupled with charged aerosol detection (CAD) was developed for quantitative analysis of lithium. The method is capable of separating lithium ion from different drug matrices and other ions in a single run thus eliminating the organic matrix and ionic analyte interferences without extensive sample preparation such as derivatization and extraction. The separation space and chromatographic conditions are defined by systematic studies of the retention behaviors of lithium and potential interfering ions and different type of pharmaceutical APIs (active pharmaceutical ingredients) under reversed-phase, HILIC and cation/anion exchange mechanisms. Compared to other current analytical techniques for lithium analysis, the presented method provides a new approach and demonstrates high sensitivity (0.02ng for LOD and 0.08ng for LOQ in both standard and sample solution). The method has been validated for pharmaceutical samples and can be potentially applied to biological, food and environmental samples.

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Novel flow-through bulk optode for spectrophotometric determination of lithium in pharmaceuticals and saliva

Cited by 22 publications

References 28 publications

Poly(o-methoxyaniline) modified electrode for detection of lithium ions

Poly(o-methoxyaniline) modified electrode for detection of lithium ions

Lithium Ion Sensors

Sensitive and direct determination of lithium by mixed-mode chromatography and charged aerosol detection

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