Poly(o-methoxyaniline) modified electrode for detection of lithium ions

Lindino, Cléber Antônio; Casagrande, Marcella; Peiter, Andréia; Ribeiro, C.

doi:10.1590/s0100-40422012000300002

Cited by 10 publications

(12 citation statements)

References 26 publications

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“…Standard techniques for blood lithium measurement such as FEP or atomic absorption spectroscopy (AAS) are not suitable for such applications because they are laboratory-based, cumbersome, expensive, and complex to operate. 11 Other techniques that have been adapted to suit clinical and home diagnostics include electrophoresis, 12,13 ion-selective electrodes, 11,14,15 and impedance spectroscopy. 16 Ion-selective electrodes can be used for point-of-care testing for determining a range of parameters.…”

Section: Introductionmentioning

confidence: 99%

Methodology for rapid assessment of blood lithium levels in ultramicro volumes of blood plasma for applications in personal monitoring of patients with bipolar mood disorder

et al. 2018

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Bipolar disorder (BD) is a common mental health condition, characterized by extreme changes in mood, energy, and behavior. BD is often managed through mood-stabilizing medications, of which lithium formulations remain the most reliable and effective at reducing the risk of suicide. To achieve adequate and consistent efficacy, lithium concentrations need to be maintained within a narrow therapeutic range (0.4 to 1.2 mmol∕L). Because of its narrow therapeutic index, long-term lithium therapy is associated with serious side effects and risks of toxicity. It is believed that the availability of a personal blood lithium analyzer would benefit patients who are on lithium treatment. We detail the results of a spectrophotometric method performed on ultramicro volumes to determine blood plasma lithium concentrations as compared with reference measurements of flame photometry, and validated in samples of unknown lithium content. Applying multiple linear regression, lithium concentrations could be determined in a rapid manner using full-range spectra or triwavelength data. Both techniques highly correlated with reference standards and could predict lithium levels accurately (R 2 ¼ 0.794214 and RMSEP ¼ 0.209584, and R 2 ¼ 0.863921 and RMSEP ¼ 0.167524, respectively). Therefore, this method can be a useful for rapid assessment of blood lithium in nonlaboratory settings i.e., general practices, hospital clinics, and community health centers by healthcare professionals and/or by patients. Future work will now focus on completion of a miniaturized and integrated system that will deliver a portable and personal lithium-monitoring device.

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Section: Introductionmentioning

confidence: 99%

Methodology for rapid assessment of blood lithium levels in ultramicro volumes of blood plasma for applications in personal monitoring of patients with bipolar mood disorder

et al. 2018

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“…Several studies have attempted to develop conductive polymer sensors for monitoring lithium levels [ 49 , 70 ]. Conductive polymers (CPs) and nanostructures are amongst commercial solid-contact ion-selective electrodes (SC-ISEs).…”

Section: Advances In Therapeutic Monitoring Of Lithium Levelsmentioning

confidence: 99%

“…Aniline and its derivatives have been extensively studied as conducting polymers due to their chemical stability, ease of polymerization and doping, as well as low cost [ 70 ]. Lindino et al reported the use of a gold electrode modified with poly(o-methoxyaniline), which is a derivative of aniline polymers, as the conducting polymer to respond to lithium ions in the concentration range of 1 × 10 −5 to 1 × 10 −4 mol L −1 [ 70 ]. The electrode modified with the conducting polymer showed a potentiometric response to Li+ concentration [ 70 ].…”

Section: Advances In Therapeutic Monitoring Of Lithium Levelsmentioning

confidence: 99%

Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder

Sheikh

Qassem

Triantis

et al. 2022

Sensors

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Since the mid-20th century, lithium continues to be prescribed as a first-line mood stabilizer for the management of bipolar disorder (BD). However, lithium has a very narrow therapeutic index, and it is crucial to carefully monitor lithium plasma levels as concentrations greater than 1.2 mmol/L are potentially toxic and can be fatal. The quantification of lithium in clinical laboratories is performed by atomic absorption spectrometry, flame emission photometry, or conventional ion-selective electrodes. All these techniques are cumbersome and require frequent blood tests with consequent discomfort which results in patients evading treatment. Furthermore, the current techniques for lithium monitoring require highly qualified personnel and expensive equipment; hence, it is crucial to develop low-cost and easy-to-use devices for decentralized monitoring of lithium. The current paper seeks to review the pertinent literature rigorously and critically with a focus on different lithium-monitoring techniques which could lead towards the development of automatic and point-of-care analytical devices for lithium determination.

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“…Secondary dopants can also change the features of the polymer as a primary dopant Possible interaction between the polymer and secondary dopant can occur by covalent bonding, van der Waals forces or hydrogen bonding that leads to variation in conformation and charge transfer. The target analytes detected by the polymer modified electrodes are considered as secondary dopants and a charge transfer complex arise between polymer and target species .…”

Section: A Brief Overview and The Characteristics Of The Modificationmentioning

confidence: 99%

Modified Electrodes for Selective Voltammetric Detection of Biomolecules

2018

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Electrochemical sensors for selective analysis of biomolecules got tremendous attention due to their better sensitivity and construction possibility of the portable cost‐effective devices. The individual or simultaneous sensing of ascorbic acid (AA), dopamine (DA), and uric acid (UA) is challenging due to their close electrooxidation and co‐existing. Recent years, substantial progress is made to develop electrode with smart materials to overcome the issue related to simultaneous sensing. This review is comparatively consolidating the work was done in fabrication of electrochemical sensors for the simultaneous sensing of AA, DA and UA. The various modification materials such as graphene, CNTs, conductive polymers and the ionic liquids characteristics are concisely described with their figure of merits. In the end, the critical analysis, future prospects, and challenges in commercialization are described.

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Poly(o-methoxyaniline) modified electrode for detection of lithium ions

Cited by 10 publications

References 26 publications

Methodology for rapid assessment of blood lithium levels in ultramicro volumes of blood plasma for applications in personal monitoring of patients with bipolar mood disorder

Methodology for rapid assessment of blood lithium levels in ultramicro volumes of blood plasma for applications in personal monitoring of patients with bipolar mood disorder

Advances in Therapeutic Monitoring of Lithium in the Management of Bipolar Disorder

Modified Electrodes for Selective Voltammetric Detection of Biomolecules

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