Novel Foveal Features Associated With Vision Impairment in Multiple Sclerosis

Hargrave, Aubrey; Sredar, Nripun; Khushzad, Fareshta; Yarp, Jennifer; Tomczak, Anna; Han, May; Kipp, Lucas; Dubra, Alfredo; Moss, Heather E.

doi:10.1167/iovs.62.12.27

Cited by 3 publications

(6 citation statements)

References 63 publications

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“…En-face OCT images of the PPW/RF and hyalocytes anterior to the ILM were generated by capturing volumetric images using the RTVue-XR Avanti (OptoVue/Visionix US, Lombard, Illinois, USA). The protocol consists of 10 volume scans of a 3.0 mm 2 retinal area over the macula and a 4.5 mm 2 centered over the ONH ( 22 ). Fewer scans (3 or more) were captured in two of the subjects.…”

Section: Methodsmentioning

confidence: 99%

“…Hyalocytes are mononuclear macrophages of the vitreous body that can be found close to the inner limiting membrane (ILM) [an average of 50 μm from the inner surface of the retina (20)] as hyperreflective white stellate structures (19). These cells have a dynamic nature and have been shown to change in terms of cell morphology and motility in response to injury and, thus, may be relevant to papilledema (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

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Application of novel non-invasive ophthalmic imaging to visualize peripapillary wrinkles, retinal folds and peripapillary hyperreflective ovoid mass-like structures associated with elevated intracranial pressure

Graven-Nielsen,

Dubra,

Dodd

et al. 2024

Front. Neurol.

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BackgroundElevated intracranial pressure (ICP) is a serious and potentially life-threatening condition, for which clinically useful non-invasive measures have been elusive, in some cases due to their inadequate sensitivity and specificity. Our aim was to evaluate novel non-invasive ophthalmic imaging of selected pathological features seen in elevated ICP, namely peripapillary hyperreflective ovoid mass-like structures (PHOMS), peripapillary wrinkles (PPW) and retinal folds (RF) as potential biomarkers of elevated ICP.MethodsThis single-center pilot study included subjects with untreated or incompletely treated high ICP. The retinas of these subjects were evaluated with averaged en-face optical coherence tomography (OCT), OCT retinal cross-sections (OCT B-scans), adaptive optics scanning light ophthalmoscopy (AOSLO), and fundus photos.ResultsSeven subjects were included in the study. 6 subjects with high ICP (5 idiopathic intracranial hypertension, 1 medication induced, 30.8 ± 8.6 years, 75% female, 5 with papilledema) and 1 control (20–25 years) were included. PHOMS, PPW and RF were present in all subjects with papilledema, but neither in the high ICP subject without papilledema nor in the control subject. Averaged en-face OCT scans and AOSLO were more sensitive for PPW and RF than OCT B-scans and commercial fundus photos.ConclusionPPW, RF and PHOMS volume have potential as non-invasive biomarkers of ICP. Novel imaging modalities may improve sensitivity. However, lack of automated image acquisition and processing limits current widespread adoption in clinical settings. Further research is needed to validate these structures as biomarkers for elevated ICP and improve clinical utility.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of novel non-invasive ophthalmic imaging to visualize peripapillary wrinkles, retinal folds and peripapillary hyperreflective ovoid mass-like structures associated with elevated intracranial pressure

Graven-Nielsen,

Dubra,

Dodd

et al. 2024

Front. Neurol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…En-face OCT images of the PPW/RF and hyalocytes anterior to the ILM were generated by capturing volumetric images using the RTVue-XR Avanti (OptoVue/Visionix US, Lombard, Illinois, USA). The protocol consists of 10 volume scans of a 3.0 mm 2 retinal area over the macula and a 4.5 mm 2 centered over the ONH (22). Fewer scans (3 or more) were captured in two of the subjects.…”

Section: Image Acquisitionmentioning

confidence: 99%

“…The AOSLO videos were registered using custom software (35) to create high signal-to-noise ratio confocal and non-confocal split detection retinal images (36). The registered images were manually tiled using Adobe Photoshop (Adobe, San Jose, California, United States) and Fiji (22). The retinal areas were then qualitatively evaluated for the presence of structural changes of the NFL, signs of axoplasmic stasis, and other potentially pathologic findings attributable to high ICP.…”

Section: Adaptive Optics Scanning Light Ophthalmoscopymentioning

confidence: 99%