Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents

Jacobsson, Josefin A.; Kloviņš, Jānis; Kāpa, Ivo; Danielsson, Pernilla; Svensson, Viktoria; Ridderstråle, Martin; Gyllensten, Ulf; Marcus, Claude; Fredriksson, Robert; Schiöth, Helgi B.

doi:10.1038/ijo.2008.168

Cited by 40 publications

(30 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Obese individuals with the GG genotype (variant c.896+223A>G) had significantly increased fasting serum insulin levels and the degree of insulin resistance. Both of these factors remained statistically significant after adjusting for BMI SDS [31,32]. The fact that FTO is associated not only with BMI but also with hip circumference and weight is consistent with previous analyses of heritability [33].…”

Section: Role Of Fto In the Genetics Of Obesitysupporting

confidence: 89%

“…Other polymorphisms of FTO (rs1421085 and c.896+ 223A>G, among others) were also examined in relation to a higher risk of developing obesity (table 1) [11,30,31]. Obese individuals with the GG genotype (variant c.896+223A>G) had significantly increased fasting serum insulin levels and the degree of insulin resistance.…”

Section: Role Of Fto In the Genetics Of Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Rendo

Moleres

Marti³

2009

Obes Facts

View full text Add to dashboard Cite

The effects of FTO on body weight, body composition, and the risk of developing overweight and obesity in children, adolescents, and adults are analyzed in this review. Most trails have been conducted on the rs9939609 SNP of the FTO gene. The minor A-allele frequency ranged from 0.38 to 0.49 in different European populations. Briefly, it has been reported that overweight-obesity risk per A-allele ranged from 1.76 to 1.35, whereas z-score for BMI has a wider variation from 0.05 to 0.5 kg/m² in European children and adolescents. As for other adiposity indexes, a waist circumference increase from 0.60 to 0.95 cm per A-allele was found together with an increase in fat mass from 0.68 to 1.78 kg in European children and adoles-cents. In regard to food intake, AA carrier subjects were reported to have reduced satiety responsiveness scores and a higher total energy and fat intake. However, it is not clear whether energy expenditure did modify the role of the rs9939609 FTO gene variant in adiposity. Furthermore, few reports examined the influence of FTO gene variants using intervention studies. Overall, it seems that the A-allele (rs9939609 FTO) is associated with higher body weight gain. However, further studies into FTO gene variants in children and adults are needed.

show abstract

Section: Role Of Fto In the Genetics Of Obesitysupporting

confidence: 89%

Section: Role Of Fto In the Genetics Of Obesitymentioning

confidence: 99%

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Rendo

Moleres

Marti³

2009

Obes Facts

View full text Add to dashboard Cite

show abstract

“…In this cohort, the average BMI was much lower than that of study subjects in previous studies. 5,9,22,23 The prevalence of obesity defined as BMI X25 kg m À2 according to Japanese criteria was 33%. DM, hypertension and MS by the Japanese definitions were exhibited by the study subjects at 7.8, 44.4 and 15.9%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese

et al. 2010

View full text Add to dashboard Cite

It was reported that gene polymorphisms in the fat-mass and obesity-associated gene (FTO) were associated with obesity and diabetes in several genome-wide association studies. A recent report indicated that FTO-knockout mice exhibited phenotypes of skinny body shape and normal metabolic profiles. Thus, FTO could be important in metabolic disorders. The aim of this study was to clarify the role of single nucleotide polymorphisms (SNPs) in FTO in metabolic disorders such as hypertension, obesity, diabetes, dyslipidemia, insulin resistance and metabolic syndrome in the Japanese general population using data from a cohort study in Hokkaido, namely the Tanno-Sobetsu study. Written informed consent for the genetic analysis was obtained from each subject participating in the study. A total of 1514 subjects were genotyped by TaqMan PCR methods for three SNPs, rs9939609, rs1121980 and rs1558902, in FTO. Association analyses between the SNPs and metabolic parameters were performed. Although two SNPs, rs9939609 and rs1558902, were not significantly associated with hypertension, obesity, metabolic syndrome or any metabolic parameters, additive and recessive models of rs1121980 were strongly associated with plasma immunoreactive insulin (IRI) level and homeostasis model assessment insulin resistance (HOMA-IR), even after adjusting for confounding factors such as age, gender and body mass index. A haplotype of three SNPs was also significantly associated with IRI and HOMA-IR. One SNP, rs1121980, and a haplotype of three SNPs in FTO that contains this SNP, might be important in the progression of insulin resistance in Japanese subjects.

show abstract

“…Actually, regarding this polymorphism, in subjects without diabetes, only in females could an association be found with both satiety in children [32] and obesity in adults [10]. A positive association of the rs9939609 polymorphism with a high fat intake has been recently demonstrated in subjects with the AA genotype without diabetes [16,33].…”

Section: Discussionmentioning

confidence: 99%

The rs9939609 Polymorphism in the <b><i>FTO</i></b> Gene Is Associated with Fat and Fiber Intakes in Patients with Type 2 Diabetes

et al. 2013

View full text Add to dashboard Cite

Background/Aims: The common polymorphism in the FTO gene (rs9939609) has been associated with obesity, type 2 diabetes, and appetite regulation. The aim of this study was to evaluate possible associations of FTO rs9939609 with dietary factors in patients with type 2 diabetes. Methods: This was a cross-sectional study of 236 patients with type 2 diabetes (age 60.0 ± 10.3 years; diabetes duration 12.7 ± 8.2 years; 53.4% females) who were genotyped for FTO rs9939609. Patients underwent clinical and laboratory evaluations and 3-day weighed diet records. Data on dietary intake were categorized as high or low, based on median values. Results: The AA genotype in the FTO gene was positively associated with high fat (>34% energy; OR = 2.17; 95% CI 1.02-4.63) and low fiber intakes (<16 g/day; OR = 2.42; 95% CI 1.05-5.57), adjusted for gender, BMI, total energy intake, systolic blood pressure, and HbA1c. When gender was taken into account, AA females had higher fat (37.4 ± 5.3 vs. 32.6 ± 7.5 and 32.2 ± 6.2% energy; p = 0.005) and lower fiber intakes (12.4 ± 4.4 vs. 15.1 ± 6.3 and 16.7 ± 5.6 g/day; p = 0.023) than patients with TT and AT genotypes. Multiple logistic regression models confirmed female associations for high fat (OR = 9.73; 95% CI 2.12-44.66) and low fiber intakes (OR = 4.28; 95% CI 1.14-16.06; p < 0.05 for all models). Conclusions: Patients with type 2 diabetes, who were carriers of the AA genotype of the FTO rs9939609, had increased fat and decreased fiber consumption, independently of BMI.

show abstract

Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents

Cited by 40 publications

References 21 publications

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese

The rs9939609 Polymorphism in the <b><i>FTO</i></b> Gene Is Associated with Fat and Fiber Intakes in Patients with Type 2 Diabetes

Contact Info

Product

Resources

About