Novel gradient casting method provides high-throughput assessment of blended polyester poly(lactic-co-glycolic acid) thin films for parameter optimization

Steele, Terry W. J.; Huang, Charlotte L.; Kumar, Saranya; Irvine, Scott Alexander; Boey, Freddy Yin Chiang; Loo, Say Chye Joachim; Venkatraman, Subbu S.

doi:10.1016/j.actbio.2012.01.014

Cited by 21 publications

(20 citation statements)

References 49 publications

(49 reference statements)

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“…Combinatorial processes are required for the synthesis of new organic multicomponent thin coatings [54,141]. In case of polysaccharides, co-electrodeposition is applied after materials are dissolved or suspended in aqueous solution and integrated into thin films [142].…”

Section: Compositional Libraries Thin Films By C-maplementioning

confidence: 99%

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Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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This chapter provides an overview of recent advances in the field of laser-based synthesis of biopolymer thin films for biomedical applications. The introduction addresses the importance of biopolymer thin films with respect to several applications like tissue engineering, cell instructive environments, and drug delivery systems. The next section is devoted to applications of the fabrication of organic and hybrid organic-inorganic coatings. Matrix-assisted pulsed laser evaporation (MAPLE) and Combinatorial-MAPLE are introduced and compared with other conventional methods of thin films assembling on solid substrates. Advantages and limitations of the methods are pointed out by focusing on the delicate transfer of bio-macromolecules, preservation of properties and on the prospect of combinatorial libraries' synthesis in a single-step process. The following section provides a brief description of fundamental processes involved in the molecular transfer of delicate materials by MAPLE. Then, the chapter focuses on the laser synthesis of two polysaccharide thin films, namely Dextran doped with iron oxide nanoparticles and Levan, followed by an overview on the MAPLE synthesis of other biopolymers. The chapter ends with summary and perspectives of this fast-expanding research field, and a rich bibliographic database.

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Section: Compositional Libraries Thin Films By C-maplementioning

confidence: 99%

“…Usually, the fabrication of a multicomponent organic coating is performed by film casting procedures [53,54]. Compositional and/or thickness gradient thin films of polymers are produced by premixing different polymer solutions, followed by applying a linear temperature gradient [55].…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Thin Films Synthesized by Advanced Pulsed Laser Techniques

Axente¹,

Sima²,

Ristoscu³

et al. 2016

Recent Advances in Biopolymers

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“…6 Briefly, 20 ml of the more viscous solution, 15% P103E (w/v dichloromethane), was poured into chamber B, and the less viscous, lower MW PLGA was poured into chamber A (that is, 20 ml 15% PLGA 5 kDa acid terminated PLGA (w/v dichloromethane)). Each well contained 65 mg (in 20 ml, B1/40 w/w of drug/polymer) of FDAc.…”

Section: Gradient Casting Plga/plga Blends Into Thin Filmsmentioning

confidence: 99%

“…Although the addition of additives is the simplest option, additives have wide ranging effects on drug/matrix phase separations and can substantially change the material properties. [4][5][6] Ideally, the best matrices would be composed of pure polyester and use alternative methods to modulate drug release without the addition of additives. This narrows the parameters to molecular weight (MW), polydispersity or changes in the polyester matrix environment, such as polyester blends or varying the terminal functional groups.…”

Section: Introductionmentioning

confidence: 99%

“…These gradient films allowed us to determine which additive was more efficient for tuning drug release and simultaneously evaluate how the various additives affected the mechanical properties. 6 A high-throughput method was concurrently used to quantify the controlled release of model hydrophobic drugs with octanol/water partition coefficients (log P) of B4. 13 We proposed that the controlled release of PLGA could be tuned to specific controlled delivery rates through gradients by altering the MW and terminal functional groups, especially acid-terminal functional groups, of PLGA.…”

Section: Introductionmentioning

confidence: 99%

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Tuning drug release in polyester thin films: terminal end-groups determine specific rates of additive-free controlled drug release

et al. 2013

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Modulating the drug release from polyester matrices independently of material properties would be beneficial to those designing biodegradable medical implants, such as drug delivery devices, stents and screws. However, the most common approaches use additives that often drastically alter the desired material properties. Recently, we have developed tools that allow gradient film formulations and high-throughput drug quantitation for the determination of parameter-specific correlations. We propose that modulated drug release can be obtained via additive-free mechanisms in polyesters by simply controlling polymer erosion through acidic terminal functional groups. Our results showed that drug release in poly(lactic-co-glycolic acid) (PLGA) formulations could be tuned to produce large ranges in drug release with relatively small changes in terminal acidic functional groups. For example, PLGA 53/47 thin films could be tuned to have 10-60% drug release at 14 days or 10-90% drug release at 20 days, depending on the PLGA/PLGA blend formulation and concentration of acidic terminal functional groups. A linear R-square correlation of up to 0.9 was observed for the acidic groups and percent drug release. Below a threshold of 1 part per thousand acidic groups, there was no increase in drug release, which has implications for polymer processing and film integrity.

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