Novel heterometallic Zn(II)-L-Cu(II) complexes: studies of the nucleophilic substitution reactions, antimicrobial, redox and cytotoxic activity

Halilagić, Asija; Selimović, Enisa; Stanković, Jelena S. Katanić; Srećković, Nikola; Virijević, Katarina; Živanović, Marko; Šmit, Biljana; Soldatović, Tanja

doi:10.1080/00958972.2022.2048376

Cited by 1 publication

(2 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…Generally, incorporating different metal ions that differ in Lewis acidity has a synergic effect [4]. The compounds of two metal ions with distinct coordination geometry and kinetic properties will have distinguishable affinity and reactivity towards biologically relevant nucleophiles [3][4][5]. The ability to coordinate into diverse geometries depending on the specific arrangement of donor atoms in biomolecules increases the cytotoxicity of these molecules [3,6].…”

Section: Introductionmentioning

confidence: 99%

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Comparative Cheminformatics Study on Structural and Physiological Similarity of Bridged Heterometallic Complexes

Redžepović,

Soldatović

2024

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In the chemical and pharmaceutical industries, many procedures are based on the principle that compounds with similar structures tend to exhibit similar activities. Therefore, the development of computational methods for decision support in similarity assessment is of utmost importance. In this proof-of-concept study, we introduce a computational framework for quantitative computation of agreement between structural and physiological similarity of compounds. As model molecules, we use bridged heterometallic complexes. To derive physiological binary vectors we use rate constants for the first substitution reaction between our compounds and some biomolecules. It is believed that such treatment of metal complexes allows a better understanding of the structure-activity relationship and can serve as a guide for new synthetic targets.

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Section: Introductionmentioning

confidence: 99%