No abstract

New dinuclear Zn(II)-L-Cu(II) complexes with different bridging ligands were synthesized. Interactions of these complexes with biologically important nucleophiles, 5′-GMP, 5′-IMP and GSH, were investigated by Uv-Vis spectrofotometric method. The distances between the metal ions lead to less reactivity of both centers due to reduced electronic communication between them and an increasing of electron density on the metal centers itself. Both complexes showed moderate antimicrobial activity against most of the tested bacterial and fungal strains.

For investigation of in vitro DNA damage protection activity four novel dinucler cisand transplatin-L-Zn(terpy), where bridging ligand L = pyrazine or 4,4'-bipyridyl, were synthesized. DNA protective effect of the complexes at various concentrations (25, 50, 100, 200, and 400 μg/mL) against the hydroxyl and peroxyl radicals-induced DNA damage were determined using two different in vitro antioxidant assays. Dinuclear complexes exhibited moderate to high DNAprotective effects which depend on the geometry of [PtCl 2 (NH 3 ) 2 ] complexes as well as the type of the bridging ligand.