Novel hybrid technology for early diagnostics of sepsis

Saknīte, Inga; Grabovskis, Andris; Kazune, Sigita; Rubīns, Uldis; Marcinkevičs, Zbigņevs; Volceka, K.; Kviesis-Kipge, Edgars; Spīgulis, Jānis

doi:10.1117/12.2253597

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Both hyperspectral and thermal camera systems allow assessing skin microcirculation [33,34]. To validate the hypothesis, we performed measurements on healthy subjects during upper arm occlusion tests.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function

et al. 2019

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The present study introduces a recently developed compact hybrid device for real-time monitoring of skin oxygen saturation and temperature distribution. The prototype involves a snapshot hyperspectral camera, multi-wavelength illuminator, thermal camera, and built-in computer with custom-developed software. To validate this device in-vivo we performed upper arm vascular occlusion on eight healthy volunteers. Palm skin oxygen saturation maps were analyzed in real-time using k-means segmentation algorithm and two-layer optical diffuse model. The prototype system demonstrated a satisfying performance of skin hyperspectral measurements in the spectral range of 507–625 nm. The results confirmed the reliability of the proposed system for in-vivo assessment of skin hemoglobin saturation with oxygen and microcirculation.

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Section: Discussionmentioning

confidence: 99%

Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function

et al. 2019

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“…In the third stage of protocol during the last minute (25 th ) of occlusion, the hyperspectral cube (HIS cube) from the hairy skin of both occluded (middle) and intact (index) finger was captured at 450nm-800nm range and 5nm spectral resolution with tunable filter hyperspectral camera, Nuance EX (CRi, UK) as depicted in Fig.1.B. The HIS cube acquisition procedure has been described in detail elsewhere 11 .…”

Section: Methodsmentioning

confidence: 99%

Hyperspectral evaluation of skin blood oxygen saturation at baseline and during arterial occlusion

Marcinkevičs

Rubīns

Grabovskis

et al. 2018

Biophotonics: Photonic Solutions for Better Health Care VI

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Skin capillary blood oxygen saturation is a clinically important diagnostic parameter, which provides valuable information for timely treatment of pathological conditions e.g. sepsis, hypoxemia or decompression illness. Hyperspectral imaging is non-invasive optical techniques with high clinical potential, however its use for skin blood oxygen saturation detection is still challenging, therefore in the present study, a method for in-vivo manipulation of skin oxygen saturation was developed, and reliability of the method evaluated by means of hyperspectral imaging in detection of oxygen saturation. In order to produce alterations of skin capillary blood parameters and oxygen saturation, the proximal phalanx of the right middle finger was occluded with a pneumatic cuff for 25 minutes. During the last minute of occlusion, the hyperspectral cubes (HIS) of both occluded and intact finger were captured, and capillary blood sample was collected for analysis with portable whole blood analyzer (REF). The group mean values for SaO 2 in intact finger skin was HIS: 89.46%±8.79% versus REF: 95.13±1.46 % and in occluded finger HSI: 25.85% ±14.00%, versus REF: 22.73±9.09 % displaying a small difference between two independent techniques, which indicate the reliability of finger occlusion model.

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Impact of increased mean arterial pressure on skin microcirculatory oxygenation in vasopressor-requiring septic patients: an interventional study

Kazune

Caica

Luksevics

et al. 2019

Ann. Intensive Care

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Background Heterogeneity of microvascular blood flow leading to tissue hypoxia is a common finding in patients with septic shock. It may be related to suboptimal systemic perfusion pressure and lead to organ failure. Mapping of skin microcirculatory oxygen saturation and relative hemoglobin concentration using hyperspectral imaging allows to identify heterogeneity of perfusion and perform targeted measurement of oxygenation. We hypothesized that increasing mean arterial pressure would result in improved oxygenation in areas of the skin with most microvascular blood pooling. Methods We included adult patients admitted to the intensive care unit within the previous 24 h with sepsis and receiving a noradrenaline infusion. Skin oxygen saturation was measured using hyperspectral imaging-based method at baseline and after the increase in mean arterial pressure by 20 mm Hg by titration of noradrenaline doses. The primary outcome was an increase in skin oxygen saturation depending upon disease severity. Results We studied 30 patients with septic shock. Median skin oxygen saturation changed from 26.0 (24.5–27.0) % at baseline to 30.0 (29.0–31.0) % after increase in mean arterial pressure ( p = 0.04). After adjustment for baseline saturation, patients with higher SOFA scores achieved higher oxygen saturation after the intervention ( r 2 = 0.21; p = 0.02). Skin oxygen saturation measured at higher pressure was found to be marginally predictive of mortality (OR: 1.10; 95% CI 1.00–1.23; p = 0.053). Conclusions Improvement of microcirculatory oxygenation can be achieved with an increase in mean arterial pressure in most patients. Response to study intervention is proportional to disease severity.

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Novel hybrid technology for early diagnostics of sepsis

Cited by 3 publications

References 23 publications

Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function

Multimodal Device for Real-Time Monitoring of Skin Oxygen Saturation and Microcirculation Function

Hyperspectral evaluation of skin blood oxygen saturation at baseline and during arterial occlusion

Impact of increased mean arterial pressure on skin microcirculatory oxygenation in vasopressor-requiring septic patients: an interventional study

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