Novel hydrophilic docetaxel (CQMU‐0519) analogue inhibits proliferation and induces apoptosis in human A549 lung, SKVO3 ovarian and MCF7 breast carcinoma cell lines

Abstract

Novel hydrophilic docetaxel analogue (CQMU-0519) inhibited cell proliferation and enhanced the intrinsic apoptotic pathway in lung and ovarian carcinoma cells, whereas it used the extrinsic one in breast adenocarcinoma cells.

Enhancement of docetaxel-treated MCF-7 cell death by 900-MHz radiation

“…However, it deserves mentioning that these pores have never been observed experimentally [26]. Indirect indication of relevancy of the theory attributed the effect of EMF to the entrance of water molecules in the defects of the membranes can be correlated to the hydrophilic analogue of docetaxel showing increased inhibition of cell proliferation with cell cycle delay at G2/M phases along with induction of apoptosis compared to the original docetaxel in MCF-7 cells [27].…”

Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells

“…Initiator and executioner caspases have been found to be activated in many types of cancer cell lines after the application of classical as well as novel taxanes (7,12,27,31,44). Activation of individual caspases seems to be cell type and also applied taxane specific.…”

“…Recently, several groups including ours have reported that caspase-2, a highly conservative protease involved in cell death induction by different stimuli (28), appears to play an important role in taxane-induced cell death (29)(30)(31). Executioner caspase-3, -7 and -6 have also been activated after taxane application in various types of cancer cells (7,12,32). Caspase-3 probably plays the most important role here, while caspase-6 and -7 seem to have minor roles (23,32).…”

“…Pro-apoptotic Bax, Bak and Bok proteins of the Bcl-2 family form channels in the outer mitochondrial membrane and thus enable the release of cytochrome c into the cytosol (11). The level of Bax was found to increase, and the level of Bak was observed to decrease as well as to increase after taxane application (11)(12)(13). The role of the Bok protein remains somewhat unclear.…”

“…The role of the Bok protein remains somewhat unclear. Similarly, the levels of antiapoptotic proteins of the Bcl-2 family, such as Bcl-2 and Bcl-xL (they prevent formation of Bax/Bak channels in mitochondrial membrane), have been reported to be increased as well as decreased after taxane application (11,12,14,15). In addition, apoptosis induced by taxanes is usually associated with Bcl-2 phosphorylation (16).…”