Novel hydrophilic N‐halamine polymer with enhanced antibacterial activity synthesized by inverse emulsion polymerization

Abstract

N-halamine-based antibacterial agents have high efficiency and rechargeable antibacterial properties. However, their applications are limited due to their complex synthetic process and fuzzy antibacterial mechanism. In this study, a novel N-halamine antibacterial polymer was synthesized by inverse emulsion polymerization and characterized by Fourier transform infrared, nuclear magnetic resonance, scanning electron microscopy, thermogravimetric analysis, and X-ray photoelectron spectroscopy. Due to the difficulty of purification, most of the subjects studied previously were hydrophobic polymers, while little research on hydrophilic polymers. In this experiment, this difficulty was overcome by controlling the dosage of sodium hypochlorite and methods of dialysis. Because of the complex cell structure of Gram-negative bacteria, it is difficult for N-halamines to release the oxidizing chlorine into the cell. However, the hydrophilic N-halamines can solve this problem, which showed a stronger antibacterial effect on Gram-negative Escherichia coli synthesized in this study. In addition, the particle size and hydrophilic property of the polymer were changed by changing the amount of initiator, and the differences in their antibacterial properties were studied.

Preparation and property of antibacterial filter membrane by coaxial electro‐spraying/electrospinning technology

“…Surface wettability is one of the important factors that affect bacterial adhesion. Hydrophilic surfaces have a greater tendency to attract and retain water molecules, and the presence of water molecules on these surfaces creates a favorable environment for bacterial adhesion when in contact with bacterial suspensions 38 . It has been reported in the literature that the hydrophilic surface can increase the adhesion of bacteria which leads to bacterial death and enhances the effectiveness of the surface antibacterial agent.…”

“…Hydrophilic surfaces have a greater tendency to attract and retain water molecules, and the presence of water molecules on these surfaces creates a favorable environment for bacterial adhesion when in contact with bacterial suspensions. 38 It has been reported in the literature that the hydrophilic surface can increase the adhesion of bacteria which leads to bacterial death and enhances the effectiveness of the surface antibacterial agent. Bacteria can attach more easily to a hydrophilic surface due to the interactions between the water molecules and bacterial cell surfaces.…”

Preparation and properties of antibacterial styrene‐acrylic emulsion based on bis‐quaternary ammonium salt‐containing mono‐methacrylates as polymerizable antibacterial agents

“…As an indispensable coating materials, the styrene‐ acrylic emulsion (SA) with antibacterial effect is highly desirable to prevent microbes infection 8 . Therefore, antibacterial modification of styrene‐acrylic emulsion (SA) has never ceased 9–12 …”