Novel hydroxyapatite nanorods crystal growth in silk fibroin/sodium alginate nanofiber hydrogel

Ming, Jinfa; Bie, Shiyu; Jiang, Zhijuan; Wang, Peng; Zuo, Baoqi

doi:10.1016/j.matlet.2014.04.025

Cited by 15 publications

(13 citation statements)

References 19 publications

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“…When fibrous hydrogels were treated by Ca 2+ ion solution, Ca 2+ ions on the SF and SA molecules get attached to PO 4 3− and OH − groups by electrostatic interaction as a driving force for nanocrystal growth. Finally, the coalescence of nanorods with the same direction formed the partially oriented bundles [9]. Therefore, it was thus clear that the morphology of HAp crystals was controlled by different fibrous hydrogels.…”

Section: Hap Crystal Growth In Fibrous Hydrogelsmentioning

confidence: 92%

“…In addition, SA hydrogels were gelled by adding 10 mM Ca 2+ solution. The morphology of SA hydrogels was interconnected nanofiber networks [9].…”

Section: Preparation Of Sf/sa Fibrous Hydrogelmentioning

confidence: 99%

“…In our previous study, we reported silk fibroin/sodium alginate (SF/SA) fibrous hydrogels to regulate and control the growth of HAp crystals. This fibrous hydrogels containing SF protein and SA polysaccharides can better mimic the real mineralization system of bone more than a single protein system [9,14,19,20]. At the same time, rectangular column and sizecontrollable HAp nanorods were controlled in SF/SA fibrous hydrogels at room temperature.…”

Section: Introductionmentioning

confidence: 95%

“…Many chemical methods have been used for the preparation of HAp crystals with controllable size and morphology, such as solution-precipitation [5], solgel synthesis [6], solid-state reaction [7], and hydrothermal method [8]. However, these methods mostly prepare irregular forms of powder [9]. Presently, the preparation of HAp crystals is developed by biomimetic approach, which is a research topic in the field of bone tissue engineering [10].…”

Section: Introductionmentioning

confidence: 99%

“…Some natural polymers containing polysaccharides (alginate, chitosan, and cellulose) and proteins (collagen, gelatin, and silk), are used to control the crystallization of HAp in recent research works [15][16][17]. However, the mineral growth environment rarely occurred in gel state [9,18]. In our previous study, we reported silk fibroin/sodium alginate (SF/SA) fibrous hydrogels to regulate and control the growth of HAp crystals.…”

Section: Introductionmentioning

confidence: 99%

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Silk fibroin/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth

Ming

Jiang

Wang

et al. 2015

Materials Science and Engineering: C

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Section: Hap Crystal Growth In Fibrous Hydrogelsmentioning

confidence: 92%

“…In addition, SA hydrogels were gelled by adding 10 mM Ca 2+ solution. The morphology of SA hydrogels was interconnected nanofiber networks [9].…”

Section: Preparation Of Sf/sa Fibrous Hydrogelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Silk fibroin/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth

Ming

Jiang

Wang

et al. 2015

Materials Science and Engineering: C

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Design, Fabrication, and Function of Silk‐Based Nanomaterials

Wang

Guo

Zhou

et al. 2018

Adv Funct Materials

137

108

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Animal silks, consisting of pure protein components, offer an extraordinary combination of strength, elongation, and toughness, exceeding most engineered materials. The secret to this success is their unique nanoarchitectures formed through the hierarchical self-assembly of silk proteins. This natural process contrasts the production of artificial silk materials, which usually are directly constructed as bulk structures from silk fibroin molecular. A variety of fabrication strategies to control nanostructures of silks or to create functional materials from silk nanoscale building blocks have been developed in the recent years. These emerging fabrication strategies offer an opportunity to tailor the structure of SF at the nanoscale and provide a promising route to produce structurally and functionally optimized silk nanomaterials. Herein, the critical roles of silk nanoarchitectures on property and function of natural silk fibers is reviewed and the strategies of utilization of these silk nanobuilding blocks is outlined. Further, the state of the art techniques to create silk nanoarchitectures and to generate silk-based nanocomponents is summarized. An effective approach to constructing sophisticated silk functional nanocomposites with promising applications in regenerative medicine, drug delivery, as well as optical and electronic device designs is provided.Further, such insights suggest templates to consider for other materials systems.

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Development of three‐dimensional printed microfibrous structures using sodium alginate/silk fibroin bioink for tissue engineering application

Majhi,

Pramanik

2023

Materialwissenschaft Werkst

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Tissue engineering is a method that involves incorporating cells using scaffold elements and growth factors to support the development or replacement of worn tissue and organs. Scaffolds, with proper form and dimension, along with natural physical and chemical features, are continually in need of improving performance and repairing damaged tissue. In this work, microfibrous three‐dimensional scaffolds composed of sodium alginate and silk fibroin natural polymers are reported. Sodium alginate/silk fibroin scaffolds were fabricated by three‐dimensional printing technique using aqueous sodium alginate/silk fibroin blends with weight ratios of 60/40, 70/30, 80/20, and 90/10. Sodium alginate/silk fibroin: (70/30) exhibited regulated swelling and degradation, responses with a tensile strength of 0.75±0.013 MPa. All the scaffolds had shown protein adsorption over 350 μg exhibiting their suitability as substrates for cell adhesion. The fabricated sodium alginate/silk fibroin scaffolds are hydrophilic and biocompatible as apparent from the contact angle, protein adsorption, 3‐[4, 5‐dimethylthiazole‐2‐yl]‐2, 5‐diphenyltetrazolium bromide (MTT) assay, and cell attachment studies. In vitro‐biomineralization study showed higher apatite layer deposition ability of the sodium alginate/silk fibroin: 70/30 scaffold. The result suggests that sodium alginate/silk fibroin: 70/30 scaffold might be used as a potential platform for tissue engineering application.

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Novel hydroxyapatite nanorods crystal growth in silk fibroin/sodium alginate nanofiber hydrogel

Cited by 15 publications

References 19 publications

Silk fibroin/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth

Silk fibroin/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth

Design, Fabrication, and Function of Silk‐Based Nanomaterials

Development of three‐dimensional printed microfibrous structures using sodium alginate/silk fibroin bioink for tissue engineering application

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