Silk fibroin/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth

Ming, Jinfa; Jiang, Zhijuan; Wang, Peng; Bie, Shiyu; Zuo, Baoqi

doi:10.1016/j.msec.2015.03.014

Cited by 35 publications

(17 citation statements)

References 32 publications

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“…Matrices of silk fibroin and chitosan with the addition of vascular endothelial growth factor contribute to the proliferation and activity of embryonic human osteoblasts [124]. Fibrous hydrogels of silk fibroin and sodium alginate enable crystals of hydroxyapatite to be obtained, having the required morphology for restoring bone tissue [125].…”

Section: Use Of Silk Fibroin and Spidroin In Tissue Engineering And Rmentioning

confidence: 99%

Silk Fibroin and Spidroin Bioengineering Constructions for Regenerative Medicine and Tissue Engineering (Review)

Agapova¹

2017

Sovrem Tehnol Med

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The review is about the developments of modern bioengineering constructs from two unique biopolymers: the main protein of silkworm silk, fibroin, and frame silk of spider web, spidroin, and their applications in regenerative medicine and tissue engineering. Both types of polymers possess such important properties as biocompatibility, biodegradability, high strength and elasticity. Availability of silkworm cocoons in nature, debugged methods of fibroin purification make this protein very perspective in bioengineering constructs. A spider web protein, spidroin, is less common in nature, but the development of alternative methods for its production makes it a promising biopolymer.The structure and properties of silk fibroin and spidroin, their advantages over other natural and synthetic polymers, technologies of biopolymer construct fabrication are considered in this review. Silk fibroin and spidroin are shown to be applied for creation of 3D matrices promoting regeneration of damaged organs and tissues, biodegradable cell carriers and pharmaceutical preparations.

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Section: Use Of Silk Fibroin and Spidroin In Tissue Engineering And Rmentioning

confidence: 99%

Silk Fibroin and Spidroin Bioengineering Constructions for Regenerative Medicine and Tissue Engineering (Review)

Agapova¹

2017

Sovrem Tehnol Med

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“…); blending with other compounds of interest, including their bulk loading, as reviewed in ref . Mineralization of prepared silk‐based scaffolds by rounds of calcium phosphate (apatite) deposition is also possible . Recently, the effects of different foetal bovine serum (FBS) types on mineralization of 3D silk‐based scaffolds were elucidated.…”

Section: Manipulating Silk Fibroin: Initial Processing and Physical Tmentioning

confidence: 99%

On the Routines of Wild-Type Silk Fibroin Processing Toward Silk-Inspired Materials: A Review

Volkov

Ferreira

Cavaco-Paulo

2015

Macromol. Mater. Eng.

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For years, silk fibroin of a domestic silkworm, Bombyx mori, has been recognized as a valuable material and extensively used. In the last decades, new application fields are emerging for this versatile material. Those final, specific applications of silk dictate the way it has been processed in industry and research. This review focuses on the description of various approaches for silk downstream processing in a laboratory scale, that fall within several categories. The detailed description of workflow possibilities from the naturally found material to a finally formulated product is presented. Considerable attention is given to (bio‐) chemical approaches of silk fibroin transformation, particularly, to its enzyme‐driven modifications. The focus of the current literature survey is exclusively on the methods applied in research and not industry.

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“…Nano-hydroxyapatite (n-HA) is the main inorganic component of bone mineral matrix, which can improve bone integration and promote bone cells proliferation. Despite much research on silk fibroin-based bioscaffolds [5], most of them are made by traditional methods [6][7]. This paper adopts 3D bioprinting technology, and uses SF, GT and n-HA as the bioink to prepare and study SF/GT/n-HA composite scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Study on the technology and properties of 3D bioprinting SF/GT/n-HA composite scaffolds

Chen

Zhang

et al. 2019

Materials Letters

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In this paper, three kinds of natural polymer materials, silk fibroin (SF), gelatin (GT), and nano-hydroxyapatite (n-HA), are mixed as 3D printing bioink to mimic protein polysaccharide and collagen fibers in natural articular cartilage. By changing the SF content, SF/GT/n-HA composite scaffolds with different ratios are prepared using 3D bioprinting technology. The microstructure and morphology, biological properties and mechanical properties of composite scaffolds are characterized. The results show that the printing precision of the bioink with 10%SF is best, and the composite scaffold with 10%SF also exhibits better mechanical properties, whose tensile elastic modulus is 10.600.32MPa and the compression elastic modulus is 1.220.06MPa. These studies are helpful to understand the interaction between SF, GT and n-HA, and provide a theoretical basis for the preparation of better silk fibroin-based composite scaffolds.

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Silk fibroin/sodium alginate fibrous hydrogels regulated hydroxyapatite crystal growth

Cited by 35 publications

References 32 publications

Silk Fibroin and Spidroin Bioengineering Constructions for Regenerative Medicine and Tissue Engineering (Review)

Silk Fibroin and Spidroin Bioengineering Constructions for Regenerative Medicine and Tissue Engineering (Review)

On the Routines of Wild-Type Silk Fibroin Processing Toward Silk-Inspired Materials: A Review

Study on the technology and properties of 3D bioprinting SF/GT/n-HA composite scaffolds

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