Study on the technology and properties of 3D bioprinting SF/GT/n-HA composite scaffolds

Wu, Xiaofang; Chen, Kai; Zhang, Dekun; Xu, Longhua; Yang, Xuehui

doi:10.1016/j.matlet.2018.11.151

Cited by 11 publications

(14 citation statements)

References 9 publications

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“…Достаточно часто используется комбинация фиброина шелка и желатина [20,21,22,79]. Фиброин шелка выступает в качестве структурного материала, обеспечивающего механические свойства геля и его биодеградацию, а желатин придает необходимую для биопечати вязкость исходному раствору и упругость скаффолду после полимеризации.…”

Section: многокомпонентные биочернилаunclassified

“…Соотношение шелка и желатина 1 : 2 (6,9%) обеспечивало оптимальные механические свойства (по модулю сжатия), скорость деградации, а также микросреду для пролиферации, дифференцировки клеток и формирования хрящевой ткани [20]. Wu et al, изменяя процентное соотношение фиброина шелка в гидрогеле на основе желатина (30%) и нано-гидроксиапатита (3%), установили, что концентрация фиброина шелка 10% обеспечивает лучшие механические свойства скаффолду (модуль упругости при растяжении составил 10,6 МПа) [21]. С возрастанием содержания фиброина шелка увеличивалось количество водородных связей между молекулами, и как следствие, степень сшивания фибрилл; скорость биодеградации при этом закономерно снижалась.…”

Section: многокомпонентные биочернилаunclassified

“…Эти материалы должны подходить как для процесса печати, так и последующего «созревания» скаффолда с инкорпорированными клетками. Для этих целей уже апробирован ряд природных биоматериалов, включая альгинат [9][10][11][12][13][14][15][16], желатин [17][18][19][20][21][22][23], коллаген [24][25][26][27][28][29][30], гиалуроновую кислоту (ГК) [17,[31][32][33][34], фиброин шелка [20][21][22], хитозан [31,35,36] и агарозу [37,38]. Достаточно широко применяются и синтетические материалы, такие как поликапролактон [9,22,[39][40][41][42] и полилактид [43][44][45].…”

Section: Introductionunclassified

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Materials for creating tissue-engineered constructs using 3D bioprinting: cartilaginous and soft tissue restoration

Аргучинская

Бекетов

Isaeva

et al. 2021

RJTAO

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3D Bioprinting is a dynamically developing technology for tissue engineering and regenerative medicine. The main advantage of this technique is its ability to reproduce a given scaffold geometry and structure both in terms of the shape of the tissue-engineered construct and the distribution of its components. The key factor in bioprinting is bio ink, a cell-laden biocompatible material that mimics extracellular matrix. To meet all the requirements, the bio ink must include not only the main material, but also other components ensuring cell proliferation, differentiation and scaffold performance as a whole. The purpose of this review is to describe the most common materials applicable in bioprinting, consider their properties, prospects and limitations in cartilage restoration.

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Section: многокомпонентные биочернилаunclassified

Section: Introductionunclassified

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Materials for creating tissue-engineered constructs using 3D bioprinting: cartilaginous and soft tissue restoration

Аргучинская

Бекетов

Isaeva

et al. 2021

RJTAO

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“…In composite bioinks, embedded colloids bind with the macromolecular chains and create reversible physical cross-links between neighboring polymer strands. These cross-links arise either from electrostatic interactions between charged particles and oppositely charged polyelectrolytes , or from hydrogen bonding between the surface of colloids and the hydroxyl and amine groups of the biopolymers composing the bioink (Figure B). − Thanks to the creation of these bonds, colloids influence the physicochemical properties of the ink in two distinct ways. First, they transform simple precursor polymer solutions (composite-free bioinks) into weakly cross-linked polymer networks with non-Newtonian behavior.…”

Section: Physicochemical Tailoring Of Bioinks By Embedded Colloidsmentioning

confidence: 99%

Hydrogel-Colloid Composite Bioinks for Targeted Tissue-Printing

Michel

Auzély‐Velty

2020

Biomacromolecules

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The development of extrusion-based bioprinting for tissue engineering is conditioned by the design of bioinks displaying adequate printability, shape stability and postprinting bioactivity. In this context, simple bioink formulations, made of cells supported by a polymer matrix, often lack the necessary versatility. To address this issue, intense research work has been focused on introducing colloidal particles into the ink formulation. By creating weak crosslinks between polymer chains, added particles modify the rheology and mechanical behavior of bioinks to improve their printability and structural integrity. Additionally, nano-and microscopic particles display composition-and structure-specific properties that can affect the cellular behavior and enhance the formation of tissue within the printed material. This review offers a comprehensive picture of the role of colloids in bioprinting from a physicochemical and biological perspective. As such, it provides guidance on devising adaptable bioinks for the fabrication of biomimetic tissues.

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“…Regarding silk composites, silk fibroin was combined with gelatin and nano-hydroxyapatite for cartilage tissue engineering, achieving compressive modulus of~1.22 MPa, printable features of 150 µm [343], and with the possibility to tune both hydrophilicity and biodegradability.…”

Section: Structural and Mechanical Propertiesmentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Study on the technology and properties of 3D bioprinting SF/GT/n-HA composite scaffolds

Cited by 11 publications

References 9 publications

Materials for creating tissue-engineered constructs using 3D bioprinting: cartilaginous and soft tissue restoration

Materials for creating tissue-engineered constructs using 3D bioprinting: cartilaginous and soft tissue restoration

Hydrogel-Colloid Composite Bioinks for Targeted Tissue-Printing

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

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