Novel N-arylamide derivatives of (S)-perillic acid ((S)-PA): in vitro and in vivo cytotoxicity and antitumor evaluation

Mukhtar, Yusif Mohammed; Wang, Kaili; Li, Ran; Deng, Wenwen; Adu‐Frimpong, Michael; Zhang, Huiyun; Zhang, Kangyi; Gu, Chenlu; Xu, Ximing; Yu, Jiangnan

doi:10.1039/c9ra03382c

Cited by 3 publications

(2 citation statements)

References 42 publications

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“…The research group investigated the in vivo anticancer activity and toxicity against organ or tissue in mice with inoculated hepatoma (H22) cancer cells. The results showed that analogues 24 and 25 exhibit inhibition properties against H22 cells with no major damage to tissues or organs ( Table 1 ) [ 49 ].…”

Section: Perillyl Alcohol and Its Derivativesmentioning

confidence: 99%

“…In melanoma cells, the propane-1,2-diyl spaced with a terpene moiety of (−)-menthol derivative 48b and (+)-neomenthol derivative 48l displayed growth inhibition at an IC 50 < 4 µM, which is 10-fold lower than seen with cisplatin (Table 1). Furthermore, presented terpene complexes (48,49) were tested for antiproliferative activity in human HT-29 colon cells. Greater and more persistent growth inhibition in HT-29 colon cancer cells upon long-term exposure is induced by the (−)-menthyl ester complexes with 2,3-diaminopropanoate (49a) and 2,4diaminobutanoate (49b) ligands compared with the 6-(aminomethyl)nicotinate analogue 48a.…”

Section: Menthol and Its Derivativesmentioning

confidence: 99%

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Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents

Zielińska-Błajet

Pietrusiak

Feder‐Kubis

2021

IJMS

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Terpenes—a diverse group of secondary metabolites—constitute the largest class of natural products abundant in almost every plant species. The properties of concrete terpenes and essential oils have been intensively studied due to their widespread use in the pharmaceutical, food and cosmetics industries. Despite the popularity of these aromatic compounds, their derivatives, terpenoids, are still not comprehensively characterized despite exhibiting potent bioactive properties. This review aims to assess the anticancer properties of selected monoterpenes including carvone, carvacrol, perillyl alcohol, perillaldehyde, limonene, menthol and their derivatives while also evaluating potential applications as novel anticancer treatments. Special attention is paid to functional groups that improve the bioactivity of monoterpene molecules. This review also covers the therapeutic potential of deep eutectic solvents that contain monoterpene substances. Taken together, the literature supports the use of monoterpene derivatives in the development of new alternatives for disease treatment and prevention.

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Section: Perillyl Alcohol and Its Derivativesmentioning

confidence: 99%

Section: Menthol and Its Derivativesmentioning

confidence: 99%

Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents

Zielińska-Błajet

Pietrusiak

Feder‐Kubis

2021

IJMS

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Brønsted acid catalyzed Prins-Ritter reaction for selective synthesis of terpenoid-derived 4-amidotetrahydropyran compounds

Sidorenko

Kurban

Peixoto

et al. 2023

Applied Catalysis A: General

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Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils

Li,

et al. 2024

Antioxidants

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Citrus peel essential oil (CPEO) is favored by people for its aromatic scent, while also possessing numerous bioactive compounds that are advantageous to human health. This study evaluated the antioxidant, anti-inflammatory, and anticancer activities of CPEOs through cell experiments. The results showed that CPEOs could increase the activity of the antioxidant enzyme system and nonenzymatic defence system in H2O2-treated RAW 264.7 cells by reducing cellular lipid peroxidation. CPEOs also reduced the nitric oxide production induced by lipopolysaccharide treatment in RAW 264.7 cells while decreasing proinflammatory cytokines expression and increasing anti-inflammatory cytokine expression. Wound healing assays, flow cytometry, and quantitative real-time fluorescent quantitative PCR (qRT-PCR) revealed that CPEOs could induce apoptosis in U87 cells through the mitochondrial apoptotic pathway. These findings indicate that CPEOs possess excellent antioxidant, anti-inflammatory, and anticancer activity potential, making them suitable for use in functional antioxidant and anti-inflammatory foods and nutritional health products.

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Novel N-arylamide derivatives of (S)-perillic acid ((S)-PA): in vitro and in vivo cytotoxicity and antitumor evaluation

Abstract: (S)-Perillic acid derivatives bearing N-aryl moiety with enhanced cytotoxic and antitumor effect against hepatocellular carcinoma and glioblastoma.

Cited by 3 publications

References 42 publications

Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents

Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents

Brønsted acid catalyzed Prins-Ritter reaction for selective synthesis of terpenoid-derived 4-amidotetrahydropyran compounds

Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils

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