Novel trans-Ferulic Acid Derivatives Containing a Chalcone Moiety as Potential Activator for Plant Resistance Induction

Abstract

A series of novel trans-ferulic acid derivatives containing a chalcone moiety were designed and synthesized to induce plant resistance. Antiviral activities of the compounds were evaluated. Bioassay results demonstrated that compounds F3, F6, F17, and F27 showed remarkable curative, protective, and inactivating activities against tobacco mosaic virus (TMV). With a 50% effective concentration (EC) value of 98.78 μg mL, compound F27 exhibited the best protective activity compared with trans-ferulic acid (328.6 μg mL), dufulin (385.6 μg mL), and ningnanmycin (241.3 μg mL). This protective ability was associated with potentiation of defense-related enzyme activity and activation of photosynthesis of tobacco at an early stage. This notion was confirmed by up-regulated expression of stress responses and photosynthesis regulating proteins. This work revealed that F27 can induce resistance and enhance plant tolerance to TMV infection. Hence, F27 can be considered as a novel activator for inducing plant resistance.

Berberine induces resistance against tobacco mosaic virus in tobacco

“…N. glutinosa was used as a local lesion host in the the anti‐TMV assay. K326 was used to determine systemic resistance against TMV and related defense responses . All experiments were conducted using tobacco plants at the five‐ to six‐leaf stage.…”

“…The host cell nuclei are subjected to virus proliferation, including nucleic acid replication and coat protein synthesis, which make the virus notably difficult to control . Ningnanmycin and ribavirin are the most widely used inhibitors of plant viruses, but display only moderate effects (30–56% effects) and have adverse environmental impacts . To date, there have been few highly effective agents against TMV, however, chemical elicitors that induce plant resistance by stimulating the plant immune response are promising agents for the control of plant diseases …”

“…2 Ningnanmycin and ribavirin are the most widely used inhibitors of plant viruses, but display only moderate effects (30-56% effects) and have adverse environmental impacts. 3,4 To date, there have been few highly effective agents against TMV, 5 however, chemical elicitors that induce plant resistance by stimulating the plant immune response are promising agents for the control of plant diseases. 6 Systemic acquired resistance (SAR) is a highly desirable form of plant resistance against a broad spectrum of pathogens that has long-lasting effects and results in less damage to crops.…”

Synthesis and antibacterial activity of chalcone derivatives containing thioether triazole

“…[31] The hydroxysubstituted acetophenone reacted with substituted formaldehyde to give the intermediate C. The intermediate D was obtained from the reaction between intermediate C and 1,2-dibromoethane. [32][33][34][35] Finally, intermediates B and D were stirred at room temperature for 8 h in DMF to give the target compounds E. The 1 H-NMR, 13 C-NMR, and HRMS of all the compounds were consistent with their structures. The characteristic peak of the target compounds at 5.86-5.89 ppm belong to -NH 2 .…”

Acetophenone and thiophene side‐arm polyaryleneethynylene conjugated polymers for enrichment of electronic applications

“…The naturally available chalcones play a beneficial role in anti‐cancer activity, bioluminescence and active plant resistance of biological applications. However, the synthetic chalcone monomers have attractive features in host–guest chemistry and optical applications.…”