Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach

Tatipamula, Vinay Bharadwaj; Kolli, Murali Krishna; Lagu, Surendra Babu; Paidi, Karuna Raman; P, Raveendra Reddy; Yejella, Rajendra Prasad

doi:10.1016/j.pharep.2018.11.004

Cited by 31 publications

(30 citation statements)

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“…In DPPH radical scavenging assay, the antioxidant substances reduce the stable purple coloured DPPH radical to a yellow coloured non-radical DPPH-H form. In general, the DPPH radical quenching activity of antioxidants are subjected to their hydrogen (donating) capacities [16,17]. As depicted in the Figure 2, the IC 50 values remained 72.0, 93.2 and 75.8 µg/mL for 1, 2 and 3, respectively, while standard ascorbic acid continued to exist at 25.5 µg/mL.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…The superoxide radical generally fetch from metabolic process/ROS, which further interact with other substrates in presence of enzyme/metal catalysed processes to generate hydroxyl radicals, H 2 O 2 and 1 O 2 . These radicals persuade oxidative damage in DNA, lipids and proteins [16,17]. In the case of superoxide radical-quenching assay of all the samples (1-3, Ga-Et and Ao-Et) were tabulated in Table S1.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

Polimati

Patnaik

Tatipamula

2019

JST

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The chemical examination of ethanolic extract of manglicolous lichen Graphis ajarekarii (Ga-Et) resulted in isolation of three known metabolites – chiodectonic acid (1), graphenone (2) and graphisquinone (3). All the isolates (1-3) and Ga-Et were screened against DPPH and superoxide free radicals, six different cancer cell lines and one normal human cell line (NHME). This work is the first report of antioxidant and cytotoxicity studies on the isolated metabolites (1-3).

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

Polimati

Patnaik

Tatipamula

2019

JST

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“…The metabolites (1-9) and RM-Ac was exposed to superoxide radical scavenging assay in triplicate, and results are reported as percentage of inhibition of superoxide free radicals [19]. To NADH (73 μM), added 15 μM of PMS and NBT (50 μM) in 20 mM phosphate buffer (pH 7.4) and standardized.…”

Section: Superoxide Radical Scavenging Assaymentioning

confidence: 99%

“…In DPPH assay, reduction of the DPPH free radicals to a DPPH-H (non-radical) form by antioxidant capable substance takes place [17,19]. As shown in Fig.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Chemical and pharmacological evaluation of manglicolous lichen Roccella montagnei Bel em. D. D. Awasthi

2019

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Background: Lichen is a composite organism composed of fungus in association with algae or cyanobacteria. Particularly, lichen betide to mangroves are named as manglicolous lichens. From the folklore, lichen extracts were used in the management of many infections and diseases. Results: The chemical investigation of acetone extract of manglicolous lichen Roccella montagnei (RM-Ac) yielded nine known metabolites namely divarinolmonomethylether (1), ethyl divaricatinate (2), divarinol (3), orcinol (4), methyl 2,6-dihydroxy-4-methylbenzoate (5), haematommic acid (6), atranol (7), ethyl haematommate (8) and ethyl orsellinate (9). Except 4, all are for the first reported from this species. The RM-Ac and its metabolites (1-9) were screened for antioxidant (DPPH, ABTS and superoxide free radical assays), anti-inflammatory, anticancer (SRB assay using A549, DLD-1, FADU, HeLa and MCF-7) and acute toxicity studies. The pharmacological results showed that compounds 6 and 8 depicted potent inhibitory profile against ABTS free radical (with IC 50 value of 40.0 and 40.5 μg/mL, respectively) and protein denaturation (with IC 50 value of 435 and 403 μg/mL, respectively). LD 50 of RM-Ac was found to be above 2 g/Kg body weight. Moreover, the RM-Ac showed prominent inhibition of formalin-hind albino rat paw oedema at both the tested doses, i.e., 100 and 200 mg/Kg b.w than that of the standard drug (indomethacin). Furthermore, the compounds 6 and 8 exhibited significant degree of specificity against HeLa, FADU and A549; besides, they showed very little degree of specificity against NHME cell line specifying less toxicity to normal cells. Conclusion: It can be concluded that the manglicolous lichen R. montagnei has an aptitude to act against free radicals, inflammation and cancer, and the main metabolites responsible for its biological activity are 6 and 8.

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AgOTf/Et₃N Cooperative Catalysis Enabled One‐Pot Access to α‐(Indolizinylethyl)‐Substituted N‐Sulfonyl Ketimines via an Imino‐Alkyne Cyclization

2022

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The β-Csp 3 À H functionalization of N-sulfonyl ketimines with 2-(2-enynl)pyridines/quinolines via a cooperative Ag(I)-/organobase-catalyzed 5-endo-dig cyclization-addition reaction is reported. This successive CÀ N/CÀ C bond-making reaction provides a simple and atom-economical technique for granting a diverse set of 1,3-disubstituted indolizines/ pyrrolo[1,2-a]quinolines possessing a synthetically resourceful N-sulfonyl ketimine moiety. Moreover, our designed strategy applies to broad substrates and allows various functionalities. Furthermore, this technique has many imperative synthetic points such as mild reaction conditions, low catalyst loading, acceptable chemical yields and highly diastereoselective (up to � 93 : 7 dr). The N-sulfonyl ketimine moiety of indolizine was easily transmuted into the reputed classes of coumarin and benzofuran derivatives.

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Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach

Cited by 31 publications

References 37 publications

CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

Chemical and pharmacological evaluation of manglicolous lichen Roccella montagnei Bel em. D. D. Awasthi

AgOTf/Et₃N Cooperative Catalysis Enabled One‐Pot Access to α‐(Indolizinylethyl)‐Substituted N‐Sulfonyl Ketimines via an Imino‐Alkyne Cyclization

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Novel indolizine derivatives lowers blood glucose levels in streptozotocin-induced diabetic rats: A histopathological approach

Cited by 31 publications

References 37 publications

CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

CHEMICAL AND PHARMACOLOGICAL EVALUATION OF MANGLICOLOUS LICHEN GRAPHIS AJAREKARII PATW. & C. R. KULK.

Chemical and pharmacological evaluation of manglicolous lichen Roccella montagnei Bel em. D. D. Awasthi

AgOTf/Et3N Cooperative Catalysis Enabled One‐Pot Access to α‐(Indolizinylethyl)‐Substituted N‐Sulfonyl Ketimines via an Imino‐Alkyne Cyclization

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AgOTf/Et₃N Cooperative Catalysis Enabled One‐Pot Access to α‐(Indolizinylethyl)‐Substituted N‐Sulfonyl Ketimines via an Imino‐Alkyne Cyclization