Novel inflammatory markers in patients with psoriasis

Yavuz, Göknur Özaydın; Yavuz, İbrahim Halil

doi:10.5505/ejm.2019.19327

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…From 9 studies [ 46 , 50 , 51 , 54 , 55 , 57 , 59 , 62 , 63 ] involving 2,731 patients, we found a weak correlation between PLT and PASI in patients with psoriasis (correlation coefficient 0.17, 95% CI 0.06–0.28, p = 0.003) (Fig. 3 ).…”

Section: Resultsmentioning

confidence: 83%

“…From 26 studies [ 8 , 9 , 36 , 38 , 39 , 41 – 50 , 52 – 59 , 61 , 63 , 66 ] involving 4,300 patients, we found that patients with psoriasis had a statistically significant increased MPV compared to controls (MD 0.61 fL, 95% CI 0.31–0.92, p < 0.001) (Fig. 4 ).…”

Section: Resultsmentioning

confidence: 87%

“…Methodological quality was variable across studies, as assessed by the NOS. Thirteen studies [ 9 , 36 , 39 – 41 , 43 , 44 , 51 , 54 , 56 , 62 , 64 , 65 ] were regarded as being high quality, eighteen studies [ 8 , 37 , 38 , 45 , 46 , 48 – 50 , 52 , 53 , 55 , 57 – 61 , 63 , 66 ] fair quality, and two studies [ 42 , 47 ] were identified as poor quality. All studies attained 3 out of 3 stars in the exposure subscale; overall methodological quality was differentiated in the subscales of selection and comparability.…”

Section: Resultsmentioning

confidence: 99%

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The association between platelet indices and presence and severity of psoriasis: a systematic review and meta-analysis

2022

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The role of platelet function indices—platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), immature platelet fraction (IPF), and platelet mass index (PMI)—in psoriasis is uncertain. This systematic review and meta-analysis aimed to evaluate the association of these platelet biomarkers with both presence and severity of psoriasis. We searched MEDLINE (Ovid), Embase (Ovid), and the Cochrane Library from inception to November 2021. To evaluate the association of platelet function indices and psoriasis, we recorded mean differences (MD) and 95% confidence intervals (CI) as well as correlation coefficients (r) for each included study, and generated summary estimates using random-effects inverse-variance modelling. We screened 1,079 unique studies, and included 33 studies with 6724 patients in the quantitative analyses. Compared with controls, patients with psoriasis had higher PLT (MD 12.86 × 109/L, 95% CI 6.34–19.39, p < 0.001), MPV (MD 0.61fL, 95% CI 0.31–0.92, p < 0.001), and PCT (MD 0.05%, 95% CI 0.01–0.09, p = 0.010), but similar PDW (MD 0.16%, 95% CI -0.46–0.79, p = 0.610). Psoriasis Area and Severity Index (PASI) was weakly correlated with PLT (r 0.17, 95% CI 0.06–0.28, p = 0.003), MPV (r 0.36, 95% CI 0.22–0.49, p < 0.001), and PDW (r 0.17, 95% CI 0.08–0.26, p < 0.001). Study numbers were insufficient to judge the relationship of IPF and PMI with psoriasis presence, or PCT, IPF, and PMI with psoriasis severity. In summary, PLT, MPV, and PCT are significantly elevated in patients with psoriasis, and PLT, MPV, and PDW are weakly correlated with PASI. Future studies are needed to evaluate the independent diagnostic and prognostic potentials of these biomarkers in patients with psoriasis.

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Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

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The association between platelet indices and presence and severity of psoriasis: a systematic review and meta-analysis

2022

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“…Of the remaining 33 publications selected for full-text studies, 11 were discarded due to missing outcome data, non-English language, or repetitive information with other studies. Eventually, 22 articles were eligible for the meta-analysis, [17–38] and the process of the selected and discarded studies is displayed in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The number of patients in the psoriatic and healthy groups changed from 20 to 320 and 20 to 200, respectively. Thirteen researches displayed that the PLT ranged from 202.0 to 296.8 Â 10 3 /mL in Karabudak, 2008 [17] Turkey Cross-sectional 23 ± 4 20/0 4 ± 4 1 3 ± 7 Tamagawa-Mineoka, 2010 [18] Japan Cross-sectional 47.0 ± 12.5 15/6 NA 16.2 ± 1.63 Canpolat, 2010 [19] Turkey Cross-sectional NA 31/27 13.5 ± 4 10.7 ± 7 Saleh, 2013 [20] Egypt Case-control 31.56 ± 10.09 13/12 6.22 ± 5.99 22.59 ± 18.07 Yurtdas ¸, 2014 [21] Turkey Cross-sectional 39 ± 9 32/19 7 ± 5 1 6 ± 11 Ahmad, 2014 [22] Pakistan Case-control 40.2 ± 10.4 16/14 NA NA Chandrashekar, 2015 [23] India Cross-sectional 44.5 ± 12.89 52/10 1.70 ± 1.74 14.90 ± 9.83 Kim, 2015 [24] Korea Case-control 39.82 ± 15.16 114/62 NA 8.56 ± 7.53 Pektas, 2016 [25] Turkey Cross-sectional 42.17 ± 11.98 84/88 NA 7.75 ± 6.85 Is ¸ik, 2016 [26] Turkey Case-control 46.00 ± 14.62 23/22 13.7 ± 11.3 16.3 ± 11.2 Unal, 2016 [27] Turkey Cross-sectional 32.41 ± 18.03 19/78 NA 5.96 ± 0.95 Kim, 2016 [28] Korea Cross-sectional 38.0 ± 16.6 62/49 NA NA Raghavan, 2017 [29] India Case-control 46.10 ± 11.99 38/12 NA 15.88 ± 2.51 Kılıç, 2017 [30] Turkey Case-control [31] Turkey Case-control 36.58 ± 9.82 25/21 13.21 ± 8.24 9.08 ± 8.78 Korkmaz, 2018 [32] Turkey Cross-sectional 43 ± 9.3 22/16 NA 3.04 ± 2.18 Farag, 2018 [33] Egypt Case-control 41.47 ± 8.16 40/30 8.4 ± 3.4 12.85 ± 4.97 Yavuz, 2019 [34] Turkey Cross-sectional 40.5 ± 15.2 NA 9.4 ± 7.3 8.1 ± 5.2 Yorulmaz, 2020 [35] Turkey Case-control 43.60 ± 13.6 102/69 9.5 ± 8.89 6.5 ± 7.56 Aktas ¸, 2020 [36] Turkey Case-control 38.28 ± 12.48 NA 10.0 ± 6.67 9.65 ± 7.78 Sirin, 2020 [37] Turkey Cross-sectional 37.91 ± 13.46 31/29 9.14 ± 7.81 10.2 ± 9.56 Özkur, 2020 [38] Turkey Case-control 45.4 ± 16. Pektas, 2016 [25] 172 Farag, 2018 [33] 70 NA NA Aktas ¸, 2020 [36] 94 NA 106.9…”

Section: Outcomes Of Platelet-associated Parameters Of Patients and C...mentioning

confidence: 99%

Platelet-associated parameters in patients with psoriasis

Zhou

2021

Medicine

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Background: The relationship between platelet-associated parameters and psoriasis has been controversial. The purpose of our meta-analysis was to assess whether platelet count, platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are associated with psoriasis.Methods: We performed a thorough documentation retrieval via PubMed, EMBASE, and Web of Science until June 2021. Pooled standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated using a random-effects model.Results: Overall, 22 studies involving 1749 patients with psoriasis and 1538 healthy controls were selected for the meta-analysis. The outcomes showed that platelet count presented non-significant differences between psoriatic patients and normal individuals (SMD = 0.12, 95% CI = À0.07 to 0.32, P = .210), while PLR (SMD = 0.28, 95% CI = 0.03-0.53, P = .031), MPV (SMD = 0.55, 95% CI = 0.30-0.79, P < .001), and PDW (SMD = 0.29, 95% CI = 0.03-0.55, P = .027) were remarkably greater in the psoriatic patients than in the healthy individuals, and similar results were found in subgroup analyses. The analytical results of susceptibility revealed that the outcomes were robust, and no evidence of substantial publication bias was identified.Conclusion: Patients with psoriasis present significantly higher PLR, MPV, and PDW than healthy individuals, suggesting that psoriasis is accompanied by low-grade systemic inflammation and platelet activation.Abbreviations: CI = confidence interval, MPV = mean platelet volume, NOS = Newcastle-Ottawa Quality Assessment Scale, PASI = the Psoriasis Area and Severity Index, PDW = platelet distribution width, PLR = platelet-to-lymphocyte ratio, PLT = platelet count, REM = random-effects model, SMD = standardized mean difference.

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