Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

“…52a). 1451 This drug delivery system could help resveratrol overcome the BBB, target the inflammatory region, increase the activity of superoxide This journal is © The Royal Society of Chemistry 2024 dismutase and glutathione peroxidase, reduce brain ROS, play a part in antioxidant stress, alleviate inflammation and exert neuroprotective effects, thereby promoting the recovery of motor function in a middle cerebral artery occlusion model (Fig. 52b and c).…”

A comprehensive review on lactoferrin: a natural multifunctional glycoprotein

“…126 In a recent study, a novel delivery system was designed using Lf functionalized hollow mesoporous manganese doped silica nanoparticles loaded with resveratrol for ischemic stroke treatment. 127 Moreover, when polyphenols and polysaccharides form a covalent complex with Lf, it can prevent the bioactive degradation in emulsions and increase their stability. Lf conjugation onto the surface of inorganic nanoparticles modifies their functional properties and stability.…”

Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction

“…Biomaterials have recently been widely used in treating SCI due to their excellent mechanical properties, degradability, and noninvasiveness. Hollow mesoporous silica nanoparticles (HMSN) are now commonly employed in drug slow-release systems. − As inorganic silica-based nanomaterials, HMSNs have a unique mesoporous structure, superior biocompatibility, stable physicochemical properties, and extensive surface area. Their hollow interior makes them highly suitable for loading drugs with a short half-life, enabling long-term sustained release to enhance therapeutic effects. , Wu Haibin et al loaded cerium dioxide into mesoporous silica nanoparticles to achieve the slow release of cerium dioxide, accelerating wound healing by continuously scavenging ROS at the injury site .…”