Novel light diffusing fiber for use in medical applications

Klubben, W. Spencer; Logunov, Stephan L.; Fewkes, Edward J.; Mooney, J.; Then, Paul M.; Wigley, P. J.; Schreiber, Horst; Matias, Kaitlyn; Wilson, Cynthia J.; Ocampo, Manuela

doi:10.1117/12.2218267

Cited by 10 publications

(5 citation statements)

References 13 publications

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“…L IGHT diffusing optical fibers (LDFs) exploitation is currently of great interest [1]- [5]. These fibers have been designed and employed mainly for lighting or light delivery in biomedical applications [1]- [2]. More recently, these fibers have been used for efficient disinfection [3], for optical communications [4] and sensing applications [5].…”

Section: Introductionmentioning

confidence: 99%

Power Coupling Between Light Diffusing Fibers: Modelling and Validation

Imperatore

Testa

Persichetti

et al. 2022

J. Lightwave Technol.

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The power coupling between two light diffusing multimodal optical fibers of equal and finite lengths that are parallel oriented, and which are coupled through scattering processes, is investigated both theoretically and experimentally. In particular, a simple analytical model of the inherent coupling coefficient, derived according to a perturbation approach in a weak-coupling regime, is developed. The modelling results have been compared with the measurements performed, as a function of fiber distance and coupling length at three different wavelengths, and a close agreement is proved. The obtained results provide a better understanding of the power coupling mechanism and of the inherent functional dependence on the main structural parameters of the two-fiber configuration.

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Section: Introductionmentioning

confidence: 99%

Power Coupling Between Light Diffusing Fibers: Modelling and Validation

Imperatore

Testa

Persichetti

et al. 2022

J. Lightwave Technol.

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“…At high dosage (fluence) blue light is toxic to human cells through the production of reactive oxygen species ( Liebmann et al, 2010 ; Ramakrishnan et al, 2016 ; Wang et al, 2020 ), however, the toxic effect of blue light on human cells can be minimized by moderating dose; for example by LED pulsing ( Gillespie et al, 2017 ), or using blocking structures in biomedical devices to protect sensitive tissues. The use of antimicrobial blue light has been suggested for use in catheters, however, there have only been a few attempts at creating viable devices with limited testing of antimicrobial efficacy ( Klubben et al, 2016 ; Vollmerhausen et al, 2017 ). Additionally there has been limited demonstration of the effect of blue light on PM viability ( Ferrer-Espada et al, 2020 ; Funjan, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A light-guiding urinary catheter for the inhibition of Proteus mirabilis biofilm formation

et al. 2022

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Catheter-associated urinary tract infection (CAUTI) is a leading cause of hospital-acquired infections worldwide causing debilitating illness for patients as well as a significant financial and treatment burden on health services. CAUTI is linked with the build-up of biofilms on catheter surfaces which act as a reservoir for infection. Additionally, urease-producing bacteria such as Gram-negative Proteus mirabilis (PM), can form crystalline biofilms which encrust catheter surfaces ultimately leading to blockages which require immediate removal of the catheter. Currently there are limited treatments available to prevent the formation of biofilms by PM as well as other urinary tract infection causing bacteria. A novel concept for a light-guiding urinary catheter is presented where a silicone elastomer waveguide incorporated along the length of the catheter is used to irradiate the catheter surfaces with antimicrobial blue light (405 nm) to prevent biofilm formation in situ. The prototype device is mass producible while also easy to fabricate in a lab setting for research studies. The inhibitory effect of blue light on PM biofilm formation over a range of irradiances is described for the first time showing an LD90 at 192–345 J/cm2 and total inhibition at 1,700 J/cm2In vitro studies show that the light-guiding catheter (LGC) prototypes exhibit a 98% inhibition in PM biofilm formation inside the catheter lumen at an average estimated irradiance of 30–50 mW/cm2 (324–540 J/cm2 fluence) showing that the concept is highly effective, promising to be a powerful and economical antimicrobial approach to prevent catheter associated biofilm development and blockage.

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“…These scattering centres efficiently provide a very uniform scattering of the propagating light through the sides and along the length of the optical fiber. Typically, this kind of fiber has been used for lighting or light delivery in biomedical applications [22], [23]. The sensor consists of two parallel LDFs coupled together.…”

Section: Introductionmentioning

confidence: 99%

Continuous Liquid Level Sensor Based on Coupled Light Diffusing Fibers

Imperatore

Persichetti

Testa

et al. 2020

IEEE J. Select. Topics Quantum Electron.

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A continuous liquid level fiber optic sensor has been devised, developed, and tested. The sensor is based on two coupled light-diffusing glass fibers. The light from a laser diode is diffused out from the first fiber by scattering and coupled, always by the scattering, to the second fiber. The working wavelength has been selected in order to be strongly absorbed by most common liquids. The optical power measured at the ends of the collection fiber depends on liquid level. Both co-propagation and counter-propagation coupling configurations have been theoretically analysed and experimentally tested. Differently from counterpropagation configuration, co-propagation configuration exhibits a linear response with the liquid level and allows level measurements with a resolution in the order of millimetres over 1 m range.

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Novel light diffusing fiber for use in medical applications

Cited by 10 publications

References 13 publications

Power Coupling Between Light Diffusing Fibers: Modelling and Validation

Power Coupling Between Light Diffusing Fibers: Modelling and Validation

A light-guiding urinary catheter for the inhibition of Proteus mirabilis biofilm formation

Continuous Liquid Level Sensor Based on Coupled Light Diffusing Fibers

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