Novel metal-based pharmacologically dynamic agents of transition metal(II) complexes: Designing, synthesis, structural elucidation, DNA binding and photo-induced DNA cleavage activity

Raman, Natarajan; Jeyamurugan, R.; Arumugam, S.; Mitu, Liviu

doi:10.1016/j.saa.2009.09.047

Cited by 60 publications

(21 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[33] The extracted plasmid DNA and RNA, pTS414 (10 μg ml À1 ) and1 μl of the test compound (50 μg ml À1 ) were mixed in 50 mM Tris-HCl buffer (pH =8.00). The contents were incubated for 8 h at 37°C.…”

Section: Gel Electrophoresismentioning

confidence: 99%

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Asekunowo

Haque

Razali

et al. 2014

Applied Organom Chemis

View full text Add to dashboard Cite

A series of new benzimidazolium salts as N-heterocyclic carbene (NHC) precursors has been synthesized. Reactions of these salts with Ag 2 O with varying metal-to-salt ratio facilitate the formation of a series of new binuclear and mononuclear Ag(I)-NHC complexes. All compounds were characterized using physicochemical and spectroscopic techniques. Single-crystal X-ray diffraction study reveals a binuclear structure for one of the complexes and a mononuclear one for two others. These complexes exist as cationic Ag(I)-NHC complexes with the chelation of carbene carbons to the silver centre in an almost linear manner. The compounds were screened for their anti-bacterial activities against Staphylococcus aureus (ATCC 12600) as a Gram-positive bacterium and Escherichia coli (ATCC 25922) as a Gram-negative bacterium. The results show that both bacteria appear markedly inhibited. Furthermore, the results suggest the possibility of steric variation as a modulation of the anti-bacterial activities. The nuclease activities of the compounds were assessed using gel electrophoresis and the results indicate that these complexes can cleave or degrade DNA and RNA via a non-oxidative mechanism.

show abstract

Section: Gel Electrophoresismentioning

confidence: 99%

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Asekunowo

Haque

Razali

et al. 2014

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…The ν(C=N) band present in the ligands is shifted to lower frequency by ca. 20 cm -1 on complexation [17]. Coupled with this, the absence of a band above 1641 cm -1 [20], characteristic of ν(-C=O) in 3-(3-phenyl-allylidene)-pentane-2,4-dione, suggests the condensation of the keto groups.…”

Section: Infrared Spectramentioning

confidence: 95%

“…The apparent absorption coefficients ε a , ε f and ε b correspond to A obsd ./[M], the extinction coefficient for the free metal(II) complex and extinction coefficient for the metal(II) complex in the fully bound form, respectively [17]. K b is given by the ratio of slope to the intercept.…”

Section: Dna Binding and Cleavage Experimentsmentioning

confidence: 99%

Novel, biologically imperative, highly versatile and planar systems: Synthesis, characterization, electrochemical behavior, DNA binding and cleavage properties of substituted β-diketimine copper(II) and zinc(II) complexes with dipyrido(3,2-a:2′, 3′ -c)phenazine ligand

Ramana¹,

Jeyamurugan²,

Balasubramanian

et al. 2010

JICS

Self Cite

View full text Add to dashboard Cite

Novel copper(II) and zinc(II) complexes of the type [ML(dppz)]Cl 2 , [L = Schiff base derived from the condensation of 3-(3-phenyl-allylidene)-pentane-2,4-dione and para-substituted aniline; X = -NO 2 (L 1 ), -H (L 2 ), -OH (L 3 ) and -OCH 3 (L 4 ); dppz = dipyrido (3,2-a:2 , 3 -c)phenazine] were synthesized and characterized by various analytical and spectral techniques. The physicochemical studies and spectral data indicated that all the complexes were monomeric and cationic with square-planar geometry. Spectroscopic data and viscosity measurements showed that the complexes intercalated to DNA with large binding constants. The substituted groups such as -NO 2 , -H, -OH and -OCH 3 in aniline moiety influenced the observed trend in the redox potentials of the complexes. The peak potential separation and formal potential of complexes were independent of sweep rate or scan rate (ν) indicating a quasireversible one-electron redox process. In all the cases, i p was linear function of ν 1/2 , as expected for diffusion controlled process, and i pa /i pc ≈ 1 at all sweep rates. It was found that the decrease in i pc was due to the higher binding of copper complexes and slowly diffusing DNA. In the presence of a reducing agent like 3-mercaptopropionic acid (MPA), the chemical nuclease activity order of the copper complexes under dark reaction condition was -NO 2 > -H > -OH > -OCH 3 . The hydrolytic cleavage of DNA by the zinc complexes was supported by the evidence from free radical quenching and T4 ligase ligation.

show abstract

“…The purity of CT DNA was ensured by monitoring the ratio of absorbance at 260 nm to that at 280 nm (A 260 /A 280 ) the value was in the range of 1.8-1.9 indicating that the DNA is sufficiently free from protein and the initial concentration of the CT DNA was confirmed from its absorption intensity at 260 nm with a molar extinction coefficient (ε) of 6600 M -1 cm -1 [15] . The electronic absorption titrations were performed by keeping a fixed complex concentration (10 -5 M).…”

Section: Electronic Absorption Spectral Titrationmentioning

confidence: 99%

Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

Sakthikumar¹,

Raja²,

Sankarganesh³

et al. 2018

pharmaceutical-sciences

View full text Add to dashboard Cite

Novel metal-based pharmacologically dynamic agents of transition metal(II) complexes: Designing, synthesis, structural elucidation, DNA binding and photo-induced DNA cleavage activity

Cited by 60 publications

References 28 publications

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Benzimidazole‐based silver(I)–N‐heterocyclic carbene complexes as anti‐bacterials: synthesis, crystal structures and nucleic acids interaction studies

Novel, biologically imperative, highly versatile and planar systems: Synthesis, characterization, electrochemical behavior, DNA binding and cleavage properties of substituted β-diketimine copper(II) and zinc(II) complexes with dipyrido(3,2-a:2′, 3′ -c)phenazine ligand

Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

Contact Info

Product

Resources

About