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Five novel copper(II) complexes have been synthesized using Schiff base ligands, synthesized by the condensation reaction of anthranilic acid and Knoevenagel b-ketoanilide condensates (obtained by the condensation of acetoacetanilide and substituted benzaldehydes). The ligands and copper(II) complexes have been characterized on the basis of Microanalytical, Mass, UV-Vis., IR, 1 H NMR, ESR, XRD and CV spectral studies, as well as magnetic susceptibility and conductivity data. On the basis of spectral studies, a square-planar geometry has been proposed for the copper(II) complexes. From the XRD data, the CuL 1 complex has the crystallite size of 50 nm respectively. The in vitro antimicrobial activity of the compounds is tested against the bacteria Escherichia coli, Salmonella typhi, Staphylococcus aureus, Klebsiella pneumoniae and Pseudonomas aeruginosa and fungi Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by well diffusion method. The complexes show stronger antimicrobial activity than the free ligands. They represent a novel class of metal-based antimicrobial agents which provide opportunities for a large number of synthetic variations for modulation of the activities.

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Knoevenagel condensate Schiff base ligands [L = 3-cinnamalideneacetylacetone-thiosemicarbazone (CAT)/3-cinnamalideneacetylacetoneethylthiosemicarbazone (CAET)/3-cinnamalideneacetylacetonephenylthiosemicarbazone (CAPT)] and their copper/zinc complexes were synthesized. They were characterized by analytical and spectral techniques. From these data it was found that the ligands adopt square-planar geometry on metalation with Cu 2+ and Zn 2+ . To evaluate the antitumor and cytotoxic activity of the synthesized complexes in mice and human cancer cell lines, the antitumor activity of the complexes was evaluated against an Ehrlich ascites carcinoma (EAC) tumor model. The activity was assessed using survival time and short-term in vitro cytotoxic activity. Oral administration of complexes (100 mg/kg) increased the survival time. The cytotoxic activity of complexes was evaluated using human breast cancer (MDA-MB-231), colon cancer (HCT-116) and nonsmall lung cancer (NCI-H-23) cell lines. Both the complexes possessed significant antitumor and cytotoxic activity on EAC and human cancer cell lines. The in vitro antimicrobial screening effect of the investigated compounds was also tested against the various organisms by well diffusion method.