Novel metal complexes of flavone Schiff base: Synthesis, characterization, antioxidant and DNA binding studies

Vincent, Sharow Geeth; Jyothi, R.R. Krishna; Joseph, J.

doi:10.1016/j.matpr.2020.03.141

Cited by 11 publications

(2 citation statements)

References 25 publications

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“…29 The binding constants were calculated from the Wolfe–Shimmer equation (eqn (4)). 61 The variables [DNA], ε a , ε f , and ε b in the formula correspond to the concentration of ct-DNA, Abs/[complex], and the molar absorptivity of 1–2 in its free and fully bound states to DNA, respectively. The intrinsic values of the binding constants for 1–2 are found to be 1.1 × 10 6 M −1 and 8.5 × 10 5 M −1 , respectively (Fig.…”

Section: Resultsmentioning

confidence: 99%

Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu(ii) and Zn(ii)-dipyrazinyl pyridine complexes

Sarkar,

Gogoi,

Palo

et al. 2024

New J. Chem.

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Section: Resultsmentioning

confidence: 99%

Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu(ii) and Zn(ii)-dipyrazinyl pyridine complexes

Sarkar,

Gogoi,

Palo

et al. 2024

New J. Chem.

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“…This in turn facilitated its interaction with sensitive cellular membranes toward the charged particles 18 . The antioxidant performance of Cu (II)‐flavone Schiff base complex using DPPH free radical assay was investigated 19 . An outstanding inhibition effect was observed on the DPPH radical by this complex confirming its ability to donate electrons to the studied free radicals resulting in their neutralization.…”

Section: Introductionmentioning

confidence: 97%

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Mostafa

Abdelaziz

Qutb

et al. 2023

Applied Organom Chemis

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Aiming to design unique metallic drugs with significant therapeutic activity, in this work, mixed ligand Cu (II) complex involving 2,2′‐bipyridine and phenylalanine [Cu (bpy) (phenala.)Cl].2H2O has been fabricated and characterized using IR spectroscopy. The interaction of Cu (II) complex with CT‐DNA molecules was examined through UV–vis absorption titration plots, thermal denaturation experiments, viscosity measurements, and electrochemical studies. Cyclic voltammetry, electrochemical impedance spectroscopy, and chronoamperometry measurements have been exploited to elucidate their binding style. The negative potential shift in ΔE and E1/2 values as well as the increased current density of Cu (II)/Cu(I) redox couple suggested the promoted rate of electron transfer process in presence of CT‐DNA molecules in the examined solution. Some kinetic parameters were also estimated such as the diffusion coefficient, the exchange current density, and Tafel slope values. Based on the results of these binding experiments, a groove and/or electrostatic interaction mode was expected. The antimicrobial activity of the studied Cu (II) complex was screened against a series of bacteria and fungi. An outstanding performance was shown when treating different Gram‐positive and Gram‐negative bacteria types. Moreover, an enhanced cytotoxicity behavior toward some human tumor cell lines, including MCF7, HEPG2, and HFB4, was detected with respective IC50 values of 43.02, 51.21, and >200 μM when incubated with Cu (II) complex for 72 h. These results suggest the application of [Cu (bpy) (phenala.)Cl].2H2O complex as a chemotherapeutic agent with a promising output in the drug discovery field.

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Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO₃, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells

Alroba,

Aazam,

Zaki

2024

ChemistrySelect

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A new ligand (HL) was prepared from heterocyclic 8‐Hydroxy‐2‐quinolinecarboxaldehyde and 2‐Aminobenzophenone in one pot synthesis. The metal complexes of the types [Zn(L)(Im)]NO3 (1), [Cu(L)(Im)]NO3 (2) and [Co(L)(Im)]NO3 (3) were prepared by adopting HL and Imidazole under refluxing conditions. The HL and complexes 1–3, were characterized by CHN elemental analysis and spectroscopic methods 1H NMR, 13C NMR, FT‐IR, ToF Mass. The spectroscopic studies suggest square pyramidal geometry in all complexes. The interaction of ligand and complexes with DNA and BSA was conducted by UV‐vis absorption and fluorescence spectroscopy. The Kb value of 2.17×104 M−1 for complex 2 is the highest depicting its greater binding propensity with DNA. Similarly, in BSA binding studies, complex 2 shows greater binding potential in the hydrophobic core probably near the Trp 212 in the subdomain IIA. Furthermore, the complex 2 shows excellent cytotoxicity on HepG2 cancer cells with IC50=74.05±0.69 μM. In the cell cycle analysis of HepG2 cells, it has been observed that complex 2 arrests the cell proliferation in the G1/S phase. Annexin V‐based flow cytometry analysis further indicated 6‐fold apoptotic cell death by complex 2 in the experiment along with non‐specific necrosis cell death.

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Novel metal complexes of flavone Schiff base: Synthesis, characterization, antioxidant and DNA binding studies

Cited by 11 publications

References 25 publications

Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu(ii) and Zn(ii)-dipyrazinyl pyridine complexes

Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu(ii) and Zn(ii)-dipyrazinyl pyridine complexes

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO₃, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells

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Novel metal complexes of flavone Schiff base: Synthesis, characterization, antioxidant and DNA binding studies

Cited by 11 publications

References 25 publications

Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu(ii) and Zn(ii)-dipyrazinyl pyridine complexes

Investigation of protein/DNA binding, and in vitro cytotoxicity of novel Cu(ii) and Zn(ii)-dipyrazinyl pyridine complexes

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO3, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells

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Synthesis and Characterization of Metal Complexes [M(L)(Im)]NO₃, In Vitro DNA/BSA Binding Behavior and Cytotoxicity on HepG2 Cancer Cells