The present work shows the results of a R&D project carried out by ELETRONORTE and by the Federal University of Pará (UFPA). Its core objective is the development of a computational system, called LANE-MAXWELL, for performing analysis and synthesis involving electromagnetic interference (EMI) in a power system substation environment. For the analysis stage, the numerical solution of the problem is obtained by numerically solving the Maxwell's equations written in a local non-orthogonal coordinate system by employing the Non-orthogonal Curvilinear Finite-Difference Time-Domain Method (LN-FDTD). The truncation of the analysis region is done by a new formulation called LN-UPML which involves the solution of the Maxwell Equations for lossy anisotropic media in a general coordinate system. For the synthesis stage, techniques such as neural networks, genetic algorithms and particle swarm optimization are used. The computational environment conceived has a friendly data input/output interface for the user, which permits a better understanding of the electromagnetic phenomena involved. For illustrate the versatility of the computational environment some practical applications involving complex power systems structures are presented.