Novel micelle-forming block copolymer composed of poly (ε-caprolactone) and poly(vinyl pyrrolidone)

Chung, Taek Woong; Cho, Kwang Yong; Lee, Hyun Chul; Nah, Jae Woon; Yeo, Joo Hong; Akaike, Toshihiro; Cho, Chong Su

doi:10.1016/j.polymer.2003.12.074

Cited by 57 publications

(34 citation statements)

References 31 publications

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“…These disadvantageous properties have stimulated the development of alternative stealth coatings. Alternatively to PEG, functionalized poly(N-vinyl-2-pyrrolidone) (PVP) can be used for preparation of micelles with a PVP shell (Benahmed et al 2001;Luo et al 2004;Chung et al 2004;Le Garrec et al 2004;Lele and Leroux 2002). PVP is the next best explored option for the corona-forming block.…”

Section: Hydrophilic Blockmentioning

confidence: 99%

Polymeric Micelles

Gaal

Crommelin

2015

Non-Biological Complex Drugs

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Section: Hydrophilic Blockmentioning

confidence: 99%

Polymeric Micelles

Gaal

Crommelin

2015

Non-Biological Complex Drugs

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“…The CMC of the polymeric micelles was determined with a fluorescence spectrometer (CARY Eclipse, Varian) using pyrene as a probe. 42,43 Polymer stock solution was prepared by dissolving the polymer (50 mg) in distilled water (100 mL), which was diluted to concentrations ranging from 1×10 -4 to 0.5 g/L. A known amount of pyrene dissolved in acetone (6×10 -7 mol/L, 5.0 mL) was added each of a series of vials, and the acetone was then evaporated.…”

Section: Synthesismentioning

confidence: 99%

“…The drug loading content of IMC was calculated according to a previously reported equation. 42,43 For this analysis, we obtained a calibration curve of standard IMC solution by measuring the UV absorbance at 320 nm (Y=19.4889X-0.00419, R 2 =0.9998).…”

Section: Synthesismentioning

confidence: 99%

Glutathione-responsive gemini polymeric micelles as controlled drug carriers

Kim

Jeong

et al. 2015

Macromol. Res.

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Gemini poly(ethylene glycol)-cystine-poly(s-butyl cysteine) ((PEG) 2 -Cyt-(PBC) 2 ) with a cystine disulfide bond as a spacer was prepared via oxidation of the cysteine group of monomeric poly(ethylene glycol)-cysteinepoly(s-butyl cysteine) (PEG-Cys-PBC) in solution, which is specifically cleavable in intracellular compartments. Due to its amphiphilic nature, (PEG) 2 -Cyt-(PBC) 2 formed micelles under aqueous conditions; the average diameter of the micelles was 26.9 nm. The critical micelle concentration (CMC) of the polymer was 15.8 mg/L. The loading content of the chosen model drug, indomethacine (IMC), was much higher for gemini micelles than that for monomeric micelles. The (PEG) 2 -Cyt-(PBC) 2 micelles released 75% of the loaded IMC within 72 h under 10 mM glutathione (GSH), whereas 36% of the loaded IMC was released from the micelles in the absence of GSH. An in vitro cytotoxicity experiment revealed that PTX-loaded gemini micelles showed toxicity to A549 cells with increasing GSH concentrations. Microscopic observation of gemini micelles demonstrated that the micelles containing a disulfide bond could effectively deliver the drug into A549 cells. These results suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers.

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“…[1][2][3][4] Biodegradable aliphatic polyesters are usually synthesized by ring-opening polymerization (ROP) in bulk or in solution. [1][2][3][4][5][6][7] Ionic ring opening polymerization is commonly used to synthesize poly ("-caprolactone) (PCL) which is an aliphatic polyester often used for biomedical applications.…”

mentioning

confidence: 99%

“…16,17 PVP has been especially used in such fields as cosmetics (detergents, soaps, hair spraying agents, dyes), medical devices (ophthalmic, lubricious coating, biocompatible coatings and complex), and for pharmaceuticals (controlled release, bind agents, stabilizers for polymerization and as thickeners) because of excellent biocompatibility properties. 4,18 PVP has variable glass transition temperatures as the molecular weight of the polymer increases (M w ¼ 9;000 (109 C) $ 1,200,000 (179 C)). 18,19 Polymer processing temperatures increase because of high glass transition temperatures.…”

mentioning

confidence: 99%

Precipitation Polymerization of 2-Methylene-1,3-dioxepane in Supercritical Carbon Dioxide

Kwon

Lee

Bae

et al. 2008

Polym J

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Free radical homopolymerization experiments were conducted with 2-methylene-1,3-dioxepane in supercritical carbon dioxide (scCO 2 ) using a heterogeneous precipitation polymerization method and AIBN as the initiator. We also synthesized copolymers of 2-methylene-1,3-dioxepane with N-vinyl-2-pyrrolidone. The influence of comonomer feed ratios on the yield, glass transition temperature (T g ) and copolymer composition was investigated. The copolymers produced were characterized by 1 H NMR, FT-IR spectroscopy and DSC. Reactivity ratios of comonomer in the initial step of the precipitation copolymerization process were estimated from copolymer composition analysis. In addition, we investigated the effect of reaction temperature on the reactivity ratios and determined that the reactivity ratios slightly increased and that MDOP had a larger deviation of reactivity ratio than that of NVP with the increased temperature. And the fine sub-micron sized copolymer particles containing with various comonomer ratios were prepared by aerosol solvent extraction system (ASES).

show abstract

Novel micelle-forming block copolymer composed of poly (ε-caprolactone) and poly(vinyl pyrrolidone)

Cited by 57 publications

References 31 publications

Polymeric Micelles

Polymeric Micelles

Glutathione-responsive gemini polymeric micelles as controlled drug carriers

Precipitation Polymerization of 2-Methylene-1,3-dioxepane in Supercritical Carbon Dioxide

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