Novel microbubble preparation technologies

Stride, Eleanor; Edirisinghe, Mohan

doi:10.1039/b809517p

Cited by 231 publications

(239 citation statements)

References 89 publications

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“…3 More recently bubbles are found to have important roles as an ultrasound imaging contrast agent, 4À6 in enhancing membrane permeability and molecular uptake, 7À9 as a stimuli-responsive carrier for drug and gene delivery, 4,10À13 as a waterdriven micromotor, 14 as template for synthesis of micro-and nanoparticles 15,16 used in catalysis, 17 in heterogeneous cavitation 18 and in surface cleaning. 19 In many of these applications, the interactions between bubbles and solids of different hydrophobicity in aqueous environments such as electrostatic, hydrophobic, specific ligandÀ receptor interactions and hydrodynamic interaction are the critical determining factors for achieving desired characteristics and functionality of bubbles.…”

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confidence: 99%

Measuring Forces and Spatiotemporal Evolution of Thin Water Films between an Air Bubble and Solid Surfaces of Different Hydrophobicity

et al. 2014

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A combination of atomic force microscopy (AFM) and reflection interference contrast microscopy (RICM) was used to measure simultaneously the interaction force and the spatiotemporal evolution of the thin water film between a bubble in water and mica surfaces with varying degrees of hydrophobicity. Stable films, supported by the repulsive van der WaalsÀCasimirÀLifshitz force were always observed between air bubble and hydrophilic mica surfaces (water contact angle, θ w < 5°) whereas bubble attachment occurred on hydrophobized mica surfaces. A theoretical model, based on the Reynolds lubrication theory and the augmented YoungÀLaplace equation including the effects of disjoining pressure, provided excellent agreement with experiment results, indicating the essential physics involved in the interaction between air bubble and solid surfaces can be elucidated. A hydrophobic interaction free energy per unit area of the form: W H (h) = Àγ(1 À cos θ w )exp(Àh/D H ) can be used to quantify the attraction between bubble and hydrophobized solid substrate at separation, h, with γ being the surface tension of water. For surfaces with water contact angle in the range 45°< θ w < 90°, the decay length D H varied between 0.8 and 1.0 nm. This study quantified the hydrophobic interaction in asymmetric system between air bubble and hydrophobic surfaces, and provided a feasible method for synchronous measurements of the interaction forces with sub-nN resolution and the drainage dynamics of thin films down to nm thickness. KEYWORDS: bubble . hydrodynamic force . hydrophobic interaction . AFM . mica . thin film drainage ARTICLE SHI ET AL.

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Measuring Forces and Spatiotemporal Evolution of Thin Water Films between an Air Bubble and Solid Surfaces of Different Hydrophobicity

et al. 2014

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“…The ability to form monodisperse segments of liquids can be successfully utilized to formulate monodisperse polymeric particles 7 of various-and easy to control-morphologies 8,9 and capsules. 10 Extensions of these techniques are used to encapsulate biomaterials, 11 prepare microbubble contrast agents for ultrasound radiography, 12 carriers of active substances for targeted drug delivery, 13 and for control of the temporal profile of their release. 14 Microfluidics offers extensive and unique control over the distribution of volumes of particles and over the process of their gelation.…”

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confidence: 99%

Microfluidic formulation of pectin microbeads for encapsulation and controlled release of nanoparticles

2011

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“…Today's UCAs exemplify the evolution of two primary routes of establishing stability: first, encapsulation of the gas microbubble within a protective external shell and, second, the substitution of ambient air with fluorinated gases (51,59). The prototypic protective shell is composed of one of the following: 1) protein, 2) phospholipid, 3) biocompatible polymer, or 4) surfactant molecules (Table 1) (51,56). Cross-linking and/or chain entanglement in the shell further enhances the stability of microbubbles.…”

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Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

Castle

Butts

Healey

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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contrast-enhanced ultrasound; gene therapy; microbubble drug delivery PRESENTLY, CONTRAST-ENHANCED ultrasound (CEUS) imaging focuses on diagnostic clinical applications. In the future, however, therapeutic uses of CEUS will create a paradigm shift for patient care and the pharmaceutical industry. Ultrasound contrast agents (UCAs) are composed of shelled microbubbles that serve as superior diagnostic agents while traversing the smallest of blood vessels resulting in unparalleled, real-time spatial and temporal imaging of intact tissues and organs. These microscopic, gas-filled microspheres acting as intravascular indicators represent ideal carrier vehicles for local delivery of ultrasound-directed drug and gene therapies. The conceptually simple application of external acoustic energy in the transformation of these inert, microspheres into powerful therapeutic systems has seemingly unlimited potential.Brief history of CEUS. All diagnostic imaging modalities use and require contrast effects to increase signal-to-noise ratios, permitting enhanced discrimination of the targets. Examples include the use of radiopaque contrast agents to create discrete image patterns using X-ray methods (ionizing radiation), thus creating enhanced detection of objects within the image plane. Similar to X-ray, positron emission tomography and radionuclide imaging procedures rely on radioactive emitters to highlight anatomy and provide information on cellular metabolism and physiology.

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Novel microbubble preparation technologies

Cited by 231 publications

References 89 publications

Measuring Forces and Spatiotemporal Evolution of Thin Water Films between an Air Bubble and Solid Surfaces of Different Hydrophobicity

Measuring Forces and Spatiotemporal Evolution of Thin Water Films between an Air Bubble and Solid Surfaces of Different Hydrophobicity

Microfluidic formulation of pectin microbeads for encapsulation and controlled release of nanoparticles

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

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