Novel Mitochondrial Ca2+ Uptake Enhancers for the Treatment of Cardiac Arrhythmia

Abstract

Intracellular calcium mediates the bidirectional coupling between excitation and contraction (ECC) in cardiac myocytes, whereby calcium affects electrophysiology and vice versa. Abnormalities in ECC can precipitate

Atrial mitochondrial calcium handling in patients with atrial fibrillation

“…Also, mitochondrial depolarisation has also been suggested to be the culprit for alternans in ventricles (Smith et al, 2013). Recently, restoration of ventricular rhythmicity by improved Ca 2+ uptake in small animal and iPSC-derived cardiomyocyte models of ventricular arrhythmia (Sander et al, 2020;Shimizu et al, 2015). Activators of mitochondrial Ca 2+ uptake such as the VDAC2 activator efsevin and the MCU activator kaempferol show a capacity to improve mitochondrial Ca 2+…”