Novel Mn3[Co(CN)6]2@SiO2@Ag Core–Shell Nanocube: Enhanced Two‐Photon Fluorescence and Magnetic Resonance Dual‐Modal Imaging‐Guided Photothermal and Chemo‐therapy

Wang, Dongdong; Guo, Zhen; Zhang, Jiajia; Chen, Jian; Zhao, Guangtao; Chen, Ruhui; He, Mengni; Liu, Zhenbang; Wang, Haibao; Chen, Qianwang

doi:10.1002/smll.201502102

Cited by 68 publications

(44 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure a illustrates the stepwise synthesis and surface modification of MCOPP NE for the O 2 generation and enhanced 1 O 2 production. First, the Mn 3 [Co(CN) 6 ] 2 MOFs were fabricated using a co‐precipitation method . Transmission electron microscopy (TEM) images reveal that the as‐prepared MOF nanoparticles had a cubic morphology and were uniformly dispersed with an average diameter of 75 nm (Figure S1, Supporting Information).…”

Section: Methodsmentioning

confidence: 99%

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

et al. 2019

Self Cite

View full text Add to dashboard Cite

Photodynamic therapy (PDT), a wellknown clinical modality that involves photosensitizer, molecular oxygen (O 2 ), and excitation light to generate cytotoxic reactive oxygen species such as singlet oxygen ( 1 O 2 ), has been proven to be a selective method for treating a wide spectrum of localized and superficial cancers or other diseases. [1][2][3][4][5][6][7][8][9] In addition to destroying cancer cells through direct photodamage, PDT can also induce vascular damage in the tumor, and activate the response of immune system. [10][11][12][13] Possessing spatial and temporal control over the localization of the light irradiation, the O 2 -involved PDT can remarkably improve the selectivity and reduce the side effects when compared to other conventional modalities such as chemotherapy, surgery, and radiotherapy. [14][15][16] On the other hand, tumor hypoxia compromises therapeutic effect of PDT, as O 2 is an indispensable element during the process. Uncontrollable growth of tumor cells as well as dysregulated formation of tumor blood vessels inevitably result in the cancer hypoxia. [17,18] In addition, microvascular collapse caused by PDT would further compromise the O 2 supply and aggravate the hypoxia condition, thus preventing effective PDT of cancer. Consequently, a vicious circle occurs, as PDT not only consumes localized O 2 , but also cuts off the O 2 supply. [19][20][21] To date, three main strategies have been employed to overcome the pre-existing hypoxia and improve the therapeutic effect of PDT. The most popular approach relies on the integration of PDT with other therapeutic modalities for a synergistic therapy. [17,22,23] However, such complex structures are often costly, which limit their scalable production and reproducibility. Another strategy is the utilization of intelligent nanomaterials that can act as O 2 carriers for direct transportation of mole cular oxygen to tumor sites. For example, Hu and coworkers reported photosensitizer-loaded perfluorocarbon nanodroplets as an O 2 self-enriched PDT nanoplatform. [24] The last approach is to construct smart nanoplatforms for in situ generation of O 2 within solid tumors based on the characteristics Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen ( 1 O 2 ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for in situ generation of endogenous O 2 to enhancethe PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O 2 generation through the...

show abstract

Section: Methodsmentioning

confidence: 99%

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Great effort has been made to design multifunctional core–shell MOFs as efficient theranostic nanoplatforms, in addition to above‐mentioned magnetic core–shell MOFs theranostic systems, and many other versatile core–shell MOF nanocomposites have shown considerable potential for nanomedical applications . For example, Wang and co‐workers introduced a versatile Mn 3 [Co(CN) 6 ] 2 @SiO 2 @Ag nanocube platform for synergistic cancer treatment . The inner core of the Mn 3 [Co(CN) 6 ] 2 MOF structure served as a T 1 – T 2 dual‐modal MRI imaging agent and two‐photon fluorescence (TPF) imaging agent; the outer shell of Ag NPs endowed the system with photothermal therapy capability and improved TPF imaging at the same time.…”

Section: Multifunctional Mofs For Cancer Theranosticsmentioning

confidence: 99%

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

2017

View full text Add to dashboard Cite

Metal-organic frameworks (MOFs)-an emerging class of hybrid porous materials built from metal ions or clusters bridged by organic linkers-have attracted increasing attention in recent years. The superior properties of MOFs, such as well-defined pore aperture, tailorable composition and structure, tunable size, versatile functionality, high agent loading, and improved biocompatibility, make them promising candidates as drug delivery hosts. Furthermore, scientists have made remarkable achievements in the field of nanomedical applications of MOFs, owing to their facile synthesis on the nanoscale and alternative functionalization via inclusion and surface chemistry. A brief introduction to the applications of MOFs in controlled drug/cargo delivery and cancer therapy that have been reported in recent years is provided here.

show abstract

“…Theranostics, which integrate cancer diagnosis and cancer treatment functions, providing an effective and convenient technique for the personalized treatment of cancer 5–7 . Therapeutic strategies such as chemotherapy, nucleic acid delivery, hyperthermia (photothermal ablation), photodynamic, and radiation therapy are combined with one or more imaging functionalities for both in vitro and in vivo studies 8 .…”

Section: Introductionmentioning

confidence: 99%

A Novel Gd-DTPA-conjugated Poly(L-γ-glutamyl-glutamine)-paclitaxel Polymeric Delivery System for Tumor Theranostics

Gao

Zhou

et al. 2017

Sci Rep

View full text Add to dashboard Cite

The conventional chemotherapeutics could not be traced in vivo and provide timely feedback on the clinical effectiveness of drugs. In this study, poly(L-γ-glutamyl-glutamine)-paclitaxel (PGG-PTX), as a model polymer, was chemically conjugated with Gd-DTPA (Gd-diethylenetriaminepentaacetic acid), a T 1 -contrast agent of MRI, to prepare a Gd-DTPA-conjugated PGG-PTX (PGG-PTX-DTPA-Gd) delivery system used for tumor theranostics. PGG-PTX-DTPA-Gd can be self-assembled to NPs in water with a z-average hydrodynamic diameter about 35.9 nm. The 3 T MRI results confirmed that the relaxivity of PGG-PTX-DTPA-Gd NPs (r 1 = 18.98 mM −1 S −1 ) was increased nearly 4.9 times compared with that of free Gd-DTPA (r 1 = 3.87 mM −1 S −1 ). The in vivo fluorescence imaging results showed that PGG-PTX-DTPA-Gd NPs could be accumulated in the tumor tissue of NCI-H460 lung cancer animal model by EPR effect, which was similar to PGG-PTX NPs. The MRI results showed that compared with free Gd-DTPA, PGG-PTX-DTPA-Gd NPs showed significantly enhanced and prolonged signal intensity in tumor tissue, which should be attributed to the increased relaxivity and tumor accumulation. PGG-PTX-DTPA-Gd NPs also showed effective antitumor effect in vivo. These results indicated that PGG-PTX-DTPA-Gd NPs are an effective delivery system for tumor theranostics, and should have a potential value in personalized treatment of tumor.Cancer is a major public health problem in most countries and is the second leading cause of death in the world 1-3 . At present, chemotherapy is still one of the most effective ways to treat cancer in clinic 4 . However, because conventional chemotherapeutic drugs cannot be traced in the body in real time, their distribution in the tumor tissue cannot be known, therefore, they cannot provide timely feedback for the clinical effectiveness of the drug. This is also the main reason why personalized treatment of cancer cannot be achieved. Many scientists believe that this is the major problem in the current clinical chemotherapy of tumor, which needs to be urgently addressed by an effective technology.Theranostics, which integrate cancer diagnosis and cancer treatment functions, providing an effective and convenient technique for the personalized treatment of cancer [5][6][7] . Therapeutic strategies such as chemotherapy, nucleic acid delivery, hyperthermia (photothermal ablation), photodynamic, and radiation therapy are combined with one or more imaging functionalities for both in vitro and in vivo studies 8 . Nanotechnology has provided a new multifunctional platform for the early diagnosis and accurate treatment of cancer and other serious diseases. Nanoparticles (NPs) have been widely used as a carrier for tumor diagnosis and treatment. NPs are generally categorized as either organic or inorganic materials. Especially, the organic NPs have attracted great attention from the scientific community in the past decades, on account of their easy functionalization, biodegradability,

show abstract

Novel Mn₃[Co(CN)₆]₂@SiO₂@Ag Core–Shell Nanocube: Enhanced Two‐Photon Fluorescence and Magnetic Resonance Dual‐Modal Imaging‐Guided Photothermal and Chemo‐therapy

Cited by 68 publications

References 51 publications

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

A Novel Gd-DTPA-conjugated Poly(L-γ-glutamyl-glutamine)-paclitaxel Polymeric Delivery System for Tumor Theranostics

Contact Info

Product

Resources

About